Figure 5

Aβ12-28P treatment prevents neuritic degeneration in APP/E2 and APP/E4 mice. (A) Representative microphotographs of coronal sections through the sensorimotor cortex at the level of the posterior caudate-putamen from vehicle- and Aβ12-28P-treated APP/E2 and APP/E4 mice stained with the Gallyas silver method. Black arrowheads indicate neuritic plaques revealed by the silver staining. (B) Mean (±SEM) of the numerical density of Gallyas-positive neuritic plaques in the neocortex and the hippocampus (n = 7–8/group). (B) * p < 0.05, ** p < 0.01, *** p < 0.001, versus vehicle-treated mice of the same APOE background (Student’s t test). ^### p < 0.001, vehicle-treated APP/E2 mice vs. vehicle-treated APP/E4 mice (Student’s t test). Scale bar 200 μm.