Aβ overproduction in mice does not cause a reduction in normalised S1P. Soluble and insoluble Aβ40 and Aβ42 (A), S1P (B), and sphingosine (C), were quantified in cortical tissue from APPswe/PS1ΔE9 (n = 4) or control C57BL/6 (n = 4) mice. S1P/sphingosine ratio is shown in (D). Mean and standard deviation are shown. Statistical significance of differences between the two sample groups was tested with t-tests, adjusted for multiple comparisons: *p < 0.05; **p < 0.01; ***p < 0.001.