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Table 1 Mean (±SD) age at onset, death and duration of illness for groups of patients with FTD, FTD + MND or MND associated with expansions in C9ORF72 , or mutations in GRN , or not known to be associated with any known FTLD or MND associated genes

From: Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72

Group M/F Age at onset (y) Age at Death (y) Duration of illness (y)
C9ORF72 FTD 7/1 61.1 ± 8.5 67.6 ± 7.0 6.5 ± 3.0
C9ORF72 FTD + MND 2/4 58.8 ± 6.1 64.7 ± 5.8 5.8 ± 6.2
C9ORF72 MND 6/1 55.8 ± 8.6 57.6 ± 7.6 2.8 ± 1.7
All C9ORF72 cases 15/6 58.9 ± 7.8 63.4 ± 7.9 5.2 ± 4.1
GRN FTD 7/5 60.8 ± 5.9 69.7 ± 3.9 8.8 ± 3.8
Non-mutational FTD 2/2 60.8 ± 11.9 68.0 ± 15.6 7.3 ± 4.1
Non-mutational FTD + MND 9/1 59.3 ± 7.0 65.4 ± 8.2 6.2 ± 3.8
All non-mutational FTD 11/3 59.6 ± 12.7 63.4 ± 13.6 2.4 ± 1.1
Non-mutational MND 12/8 59.7 ± 8.2 66.1 ± 10.2 6.5 ± 3.8
  1. FTD = Frontotemporal Dementia, FTD + MND + Frontotemporal dementia and Motor Neurone disease, MND = Motor Neurone Disease.