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Table 2 Markers with independent prognostic value (Glioblastoma and Anaplastic Astrocytoma patients only)

From: Prognostic and predictive markers in recurrent high grade glioma; results from the BR12 randomised trial

Marker N HR (95% CI) p-value Overall p-value
Chromosome 1     
 Normal 153 -   0.358
 Trisomy 4 0.92 (0.29-2.92) 0.885  
 Any other abnormality 104 1.22 (0.93-1.59) 0.157  
1p status     
 Normal 178 -   0.828
 Total loss of 1p 3 1.00 (0.24-4.10) 0.996  
 Any other abnormality 80 1.09 (0.82-1.45) 0.537  
1p36 status     
 Normal 192 -   0.646
 Loss of 1 copy 53 1.05 (0.75-1.45) 0.787  
 Loss of both copies 6 1.75 (0.76-4.05) 0.187  
 Any other abnormality 10 1.18 (0.57-2.42) 0.654  
Chromosome 7     
 Normal 58 -   0.029
 Monosomy 1 0.44 (0.06-3.35) 0.426  
 Trisomy 145 1.64 (1.11-2.42) 0.014  
 Any other abnormality 57 1.17 (0.77-1.79) 0.455  
Chromosome 10     
 Normal 38 -   0.006
 Monosomy 150 1.41 (0.91-2.19) 0.127  
 10q partial deletion 59 0.76 (0.48-1.21) 0.241  
 Any other abnormality 14 1.24 (0.58-2.65) 0.583  
PTEN     
 Normal 80 -   0.001
 Hemizygous deletion 172 1.85 (1.32-2.60) <0.001  
 Homozygous deletion 9 1.31 (0.62-2.81) 0.480  
MGMT     
 Normal 43 -   0.776
 Hemizygous deletion 217 1.05 (0.72-1.54) 0.797  
 Homozygous deletion 1 2.22 (0.30-16.56) 0.438  
Chromosome 19     
 Normal 161 -   0.565
 Monosomy 4 1.91 (0.69-5.25) 0.210  
 Trisomy 52 1.14 (0.82-1.60) 0.442  
 Any other abnormality 44 0.95 (0.66-1.36) 0.772  
19q status     
 Normal 166 -   0.754
 Total loss of 19q 3 1.10 (0.27-4.55) 0.898  
 Any other abnormality 92 1.11 (0.84-1.47) 0.454  
19q13 status     
 Normal 166 -   0.643
 Loss of 1 copy 23 0.99 (0.60-1.62) 0.968  
 Any other abnormality 72 1.15 (0.85-1.55) 0.355  
EGFR     
 Normal 157 -   0.013
 Amplified 104 1.42 (1.08-1.87) 0.013  
CDKN2A     
 Normal 111 -   0.771
 Hemizygous deletion 78 1.09 (0.79-1.51) 0.587  
 Homozygous deletion 72 1.12 (0.80-1.58) 0.500  
MDM2     
 Normal 239 -   0.591
 Amplified 22 1.13 (0.72-1.78) 0.586  
CDK4     
 Normal 233 -   0.083
 Amplified 28 1.46 (0.97-2.21) 0.070  
PDGFRA     
 Normal 244 -   0.998
 Amplified 17 1.00 (0.60-1.68) 0.997  
Chromosome 13     
 Normal 184 -   0.760
 Monosomy 37 1.15 (0.79-1.68) 0.460  
 Trisomy 1 0.86 (0.12-6.34) 0.886  
 Partial deletion 28 1.34 (0.85-2.11) 0.207  
 Any other abnormality 11 1.10 (0.53-2.28) 0.808  
RB1 gene status     
 Normal 195 -   0.469
 Hemizygous deletion 65 1.22 (0.89-1.66) 0.221  
 Homozygous deletion 1 0.86 (0.12-6.26) 0.878  
RB1 pathway     
 Normal 71 -   0.061
 Abnormal 190 1.35 (0.98-1.87) 0.066  
TP53 mutation     
 No 47 -   0.296
 Yes 83 0.80 (0.53-1.21) 0.293  
p53 pathway     
 Normal 12 -   0.265
 Abnormal 207 1.46 (0.73-2.91) 0.289  
IDH1     
 Normal 198 -   <0.001
 Mutation 77 0.38 (0.26-0.56) <0.001  
MGMT methylation     
 <10% 71 -   <0.001
 ≥10% 204 0.45 (0.34-0.60) <0.001