Effects of suppression of mutant tau expression on Arc::dVenus responses. Arc::dVenus expression in different brain regions of rTg4510 mice and control littermates is presented as medians with interquartile ranges. No significant effect of doxycycline treatment on Arc::dVenus responses were observed in either transgenic or control mice, when corrected for multiple testings. Numbers of mice and neurons for untreated control littermate and transgenic mice are as indicated in Figure 3 legend. Numbers of mice and neurons for doxycycline-treated group are as following: n = 5 control littermates, 3 transgenic mice; EPd: control: n = 449 neurons, transgenic: 267; CLA: control: n = 480 neurons, transgenic: 272; PIR: control: n = 1091 neurons, transgenic: 527; CA1: control: n = 479 neurons, transgenic: 196; VISam2/3: control: n = 1060 neurons, transgenic: 729; VISp6: control: n = 730 neurons, transgenic: 534; AUD2/3: control: n = 1394 neurons, transgenic: 1098; AUD6: control: n = 697 neurons, transgenic: 736.