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Table 2 Toxicity and efficacy of TMZ and propargyl in combination with PARP inhibitor rucaparib in MB cell lines

From: Overcoming multiple drug resistance mechanisms in medulloblastoma

Cell line IC50TMZ IC50TMZ + Rucaparib PF IC50Propargyl IC50Propargyl + Rucaparib PF
DAOY 540 ± 70.2 253 ± 35.1 1.9* 68.3 ± 26.2 47.9 ± 4.6 1.4
MED1 31 ± 12.4 26.8 ± 10.9 1.2 42.2 ± 9.5 43.4 ± 14 1.0
UW228-3 290 ± 14.8 129.5 ± 12 2.2* 96.3 ± 21.2 94.3 ± 38 1.0
MED3 332.9 ± 81.8 124.7 ± 55.3 2.7** 53.6 ± 16.8 56.3 ± 26.6 1.0
  1. Abbreviation: IC50 = concentration resulting in 50% inhibition. PF = potentiation factor. ٭٭P = 0.002; ٭P < 0.05 (unpaired student’s t-test). Result of n ≥ 3 experiments, all performed in duplicate.