Overcoming multiple drug resistance mechanisms in medulloblastoma

Table 2 Toxicity and efficacy of TMZ and propargyl in combination with PARP inhibitor rucaparib in MB cell lines

Cell line	IC₅₀TMZ	IC₅₀TMZ + Rucaparib	PF	IC₅₀Propargyl	IC₅₀Propargyl + Rucaparib	PF
DAOY	540 ± 70.2	253 ± 35.1	1.9*	68.3 ± 26.2	47.9 ± 4.6	1.4
MED1	31 ± 12.4	26.8 ± 10.9	1.2	42.2 ± 9.5	43.4 ± 14	1.0
UW228-3	290 ± 14.8	129.5 ± 12	2.2*	96.3 ± 21.2	94.3 ± 38	1.0
MED3	332.9 ± 81.8	124.7 ± 55.3	2.7**	53.6 ± 16.8	56.3 ± 26.6	1.0

Abbreviation: IC₅₀ = concentration resulting in 50% inhibition. PF = potentiation factor. ٭٭P = 0.002; ٭P < 0.05 (unpaired student’s t-test). Result of n ≥ 3 experiments, all performed in duplicate.

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