Figure 6

Composite layer separation of peripapillary OCT circle scans from 16-month-old Cln3 ^+/+ and Cln3 ^-/- mice. A: Representative excerpts of OCT circle scans from Cln3 ^+/+ and Cln3 ^-/- mice with indication of the defined layers. Scale bar: 200 μm. B: There was a significant reduction of the inner but not outer retina thickness in Cln3 ^-/- mice (n = 4 per group). Student’s t-test. *** P < 0.001. C: Significant thinning was detected in NFL/GCL/IPL and INL of Cln3 ^-/- mice, but not in other retinal layers. Student’s t-test. ** P < 0.01. n.s. = not significant.