Assessment of retina thickness in OCT volume scans. A: Representative interpolated thickness maps from retinal volume scans of 7-month-old Ppt1
+/+ and Ppt1
-/- mice and 16-month-old Cln3
+/+ and Cln3
-/- mice. A segmented circular OCT grid was centered on the optic disc and retina thickness was calculated by averaging the values of the 4 outer areas (yellow filling). Scale bars correspond to 70 μm of subtended retina. B: Retina thickness was significantly reduced in Ppt1
-/- and Cln3
-/- mice compared to age-matched control littermates (n = 4 per group). Student’s t-test. * P < 0.05.