Figure 5

NMO pathology in seropositive rats is complement-dependent. A. (top) Experimental protocol. (bottom) Cytotoxicity in AQP4-expressing CHO cells incubated with 10 μg/ml NMO-IgG and 5% serum from cobra venom factor (and control saline) treated rats (S.E., n = 3, ** P < 0.01). B. AQP4, GFAP and MBP immunofluorescence at 5 days.