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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: Experimental treatment of NRAS-mutated neurocutaneous melanocytosis with MEK162, a MEK-inhibitor

Figure 1

Brain and spinal MRI images. A. MRI of the brain showed an enlarged fourth ventricle in contact with a retrocerebellar cyst extending through the foramen magnum, and an enlarged subarachnoid cistern anterior to the brainstem, extending from the medulla oblongata towards the floor of the third ventricle. The brain stem appeared to be compressed or atrophied due to the combined pressure from these cysts. T1 weighted image with contrast. B. Spinal MRI showed a widened spinal canal and a distorted and atrophic spinal cord, due to the presence of multiple cysts with extensive leptomeningeal and dural contrast enhancement without the presence of solid masses. T1 weighted image with contrast. C and D. MRI of the brain and spinal cord, a few months after surgery, showed progressive leptomeningeal lesions of the brain and spinal cord with (further) compression of these structures and hydrocephalus (C with, D without contrast).

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