Table 2 IHC properties of new TDP-43 MAbs
From: Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins
Region/antibody | Spinal cord | Temporal cortex | ||||||
|---|---|---|---|---|---|---|---|---|
Nuclei | LMN | GCI | Nuclei | NCI | DN | NII | GCI | |
A (aa 6–24) | ||||||||
211 | +++ | + | + | +++ | 0 | 0 | 0 | 0 |
B (aa 25–181) | ||||||||
5031 | ++ | +++ | + | ++ | r | + | + | r |
C (aa 182–261) | ||||||||
138 | 0 | +++ | + | 0 | +++ | ++ | + | + |
5060 | +++ | +++ | + | ++ | + | + | ++ | r |
D (aa 287–322) | ||||||||
5117 | ++ | ++ | r | +++ | +++ | ++ | r | ++ |
5156 | +++ | +++ | r | +++ | +++ | +++ | + | ++ |
E (aa 262–391) | ||||||||
205 | +++ | +++ | r | ++ | +++ | ++ | + | + |
241 | ++ | +++ | + | ++ | +++ | ++ | + | + |
5053 | +++ | +++ | + | +++ | +++ | +++ | ++ | + |
5056 | ++ | ++ | r | +++ | +++ | +++ | ++ | + |
5095 | +++ | ++ | r | +++ | ++ | ++ | ++ | + |
F (aa 392–414) | ||||||||
5195 | + | +++ | r | +++ | ++ | ++ | ++ | + |