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Table 2 IHC properties of new TDP-43 MAbs

From: Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins

Region/antibody Spinal cord Temporal cortex
Nuclei LMN GCI Nuclei NCI DN NII GCI
A (aa 6–24)         
211 +++ + + +++ 0 0 0 0
B (aa 25–181)         
5031 ++ +++ + ++ r + + r
C (aa 182–261)         
138 0 +++ + 0 +++ ++ + +
5060 +++ +++ + ++ + + ++ r
D (aa 287–322)         
5117 ++ ++ r +++ +++ ++ r ++
5156 +++ +++ r +++ +++ +++ + ++
E (aa 262–391)         
205 +++ +++ r ++ +++ ++ + +
241 ++ +++ + ++ +++ ++ + +
5053 +++ +++ + +++ +++ +++ ++ +
5056 ++ ++ r +++ +++ +++ ++ +
5095 +++ ++ r +++ ++ ++ ++ +
F (aa 392–414)         
5195 + +++ r +++ ++ ++ ++ +
  1. This table summarizes the IHC characteristics of the new MAbs described here. They are identified by the numbers in the first column under A-F. The aa numbers in parenthesis indicates the different protein domains within which the epitopes reside that are recognized by these new MAbs. New abbreviations: Nuclei = Normal endogenous TDP-43 staining; LMN = lower motor neuron cytoplasmic inclusions, r = rare.