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Figure 4 | Acta Neuropathologica Communications

Figure 4

From: Distinct origins of dura mater graft-associated Creutzfeldt-Jakob disease: past and future problems

Figure 4

Transmission of dCJD or sCJD to humanized mice carrying human PrP with either the 129 M/M or 129 V/V genotype. (a) p-dCJD and sCJD-VV2, −MV2K, or -MV2K + C were identical in the transmissibility to the PrP-humanized mice. (b) Immunohistochemical analysis of PrPSc in the mouse brain revealed that p-dCJD and sCJD-VV2, −MV2K, or -MV2K + C were indistinguishable with regard to the neuropathological phenotypes in the inoculated mice. G, gray matter; W, white matter. (c) Westernblot analysis of PrPSc in the mouse brain showed that p-dCJD and sCJD-VV2, −MV2K, or -MV2K + C were also indistinguishable with regard to the biochemical properties of PrPSc in the inoculated mice. 129 M/M, knock-in mice expressing human PrP with the 129 M/M genotype; 129 V/V, knock-in mice expressing human PrP with the 129 V/V genotype.

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