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Figure 1 | Acta Neuropathologica Communications

Figure 1

From: Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres

Figure 1

Arsenic trioxide inhibits glioblastoma neurosphere growth and proliferation. A) MTS assays showing growth inhibition following ATO treatment in the 040821, HSR-GBM1 and 040622 glioblastoma neurosphere lines, with a bar graph highlighting the significance compared to vehicle. B) Representative BRDU staining images showing anti-BRDU staining (red) and DAPI counterstaining (blue) in vehicle and 5 μM ATO-treated 040622 neurosphere cells are shown in the top left panel. The percentage of BRDU positive cells in 040622, 040821 and HSR-GBM1 neurospheres was significantly decreased in all three lines after treatment with either 2.5 μM or 5 μM ATO.

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