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Table 1 List of experiments performed on M83 mice

From: Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA

Experiment Passage Inoculum (brain equivalent or quantity of recα-syn) Survival period (d.p.i.) Median/maximal survival (days old) αSddetection by Western blot or ELISA or IHC
1 P1 (2 mg) 129 +/− 19 192/217 8/8
2 αSrec fib (10 μg) 106 +/− 27 145/216 6/6
3 P2 (10 mg) 105 +/− 23 146/181 5/5
4 P2 (2 mg) 107 +/− 12 147/173 8/8
5 P2 (0.4 mg) 140 +/− 33 188/232 9/10
6 P2 Stx hippocampus (2 mg) 130 +/− 13 171/196 5/5
7 P2 Stx cerebellum (2 mg) 131 +/− 50 159/187 4/4
8 P2 spinal cord (2 mg) 113 +/− 22 163/174 5/5
9 P2 cerebral cortex (2 mg) 224 +/− 93 219/472 5/5
10 P2 spleen (2 mg) 378 +/− 98 374/584 4/5
  1. Inoculations were performed at 6 weeks except for experiment 1 (9 weeks).
  2. P1: passage 1, P2: passage 2, Stx: stereotactic, d.p.i.: days post inoculation.
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