Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

Table 3 Association between NI, tau/Aβ _1–42 ratios and cognitive scores in CN subject with conversion to MCI/DAT

Neuronal injury marker	Hazard ratio	95% confidence interval	p-value
aHV: <=160 weeks	3.11	1.84-5.25	<0.0001
aHV: >160 weeks¹	0.92	0.56-1.53	0.76
SPARE-AD	1.46	1.12-1.92	0.006
HCI	1.26	0.84-1.88	0.27
PC-FDG-PET	1.37	0.92-2.03	0.12
T-tau/Aβ_1–42	1.60	1.09-2.36	0.016
P-tau/Aβ_1–42	1.49	0.52-2.26	0.065
Memory summary score	2.46	1.69-3.56	<0.0001

¹For aHV a heaviside function with a time cutpoint of 160 was selected based on the distribution of the Schoenfeld residuals indicating that after 3 years group did not differ in risk.
Cox hazards models were adjusted for age, education, gender and APOE ϵ4 presence. Biomarker values were normalized and standardized for comparison.

ISSN: 2051-5960