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Table 3 Association between NI, tau/Aβ 1–42 ratios and cognitive scores in CN subject with conversion to MCI/DAT

From: Neuronal injury biomarkers and prognosis in ADNI subjects with normal cognition

Neuronal injury marker Hazard ratio 95% confidence interval p-value
aHV: <=160 weeks 3.11 1.84-5.25 <0.0001
aHV: >160 weeks1 0.92 0.56-1.53 0.76
SPARE-AD 1.46 1.12-1.92 0.006
HCI 1.26 0.84-1.88 0.27
PC-FDG-PET 1.37 0.92-2.03 0.12
T-tau/Aβ1–42 1.60 1.09-2.36 0.016
P-tau/Aβ1–42 1.49 0.52-2.26 0.065
Memory summary score 2.46 1.69-3.56 <0.0001
  1. 1For aHV a heaviside function with a time cutpoint of 160 was selected based on the distribution of the Schoenfeld residuals indicating that after 3 years group did not differ in risk.
  2. Cox hazards models were adjusted for age, education, gender and APOE ϵ4 presence. Biomarker values were normalized and standardized for comparison.