Clinicopathological correlates of intragenic copy number breaks in paediatric high grade glioma . (a) Number of intragenic breaks per sample in a series of 100 pHGG. (b) Kaplan-Meier plot of overall survival stratified by number of intragenic breaks per sample. Pink: no breaks; Red: more than 10 breaks per sample; Grey: rest. (c-f) Boxplot of number of intragenic breaks per sample separated by - (c) WHO grade. Orange: grade III; Brown: grade IV. (d) Previous radiation treatment for an earlier malignancy. Grey: primary pHGG; Purple: post-irradiation; (e) Age at diagnosis. Yellow: infant (<3 years old); Dark yellow: older children (>3 years old). (f) H3F3A status. Blue: G34R/V; Green: K27M; Grey: wild-type.