Granular/dot-like deposits and skein-like/rounded inclusions, associated with loss of nuclear TDP. Diffuse staining pattern of TDP43 in the nucleus (a) (arrowhead), suggestive of intranuclear native TDP43. The granular/dot-like deposits scattered into the cytoplasm (thin arrow) (a-c) and nucleus (empty arrowhead) (b). The rounded inclusions in dendrites (c) and cytoplasm (d) (thick arrows). The nuclear TDP43 hardly detectable in the neurons with rounded inclusions (empty arrows) (c, d). Bars = 20 μm.