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Table 1 MtDNA variants identified from sequencing the non-coding region of mtDNA using the Ion Torrent PGM on 12 cell lines representative of GBM

From: The identification of mitochondrial DNA variants in glioblastoma multiforme

    Percentage change in variant (%)  
Reference position Reference Variant HSR-GBM1 GBM L1 GBM L2 GBM 4 GBM 6 CSC 014 CSC 020 NO7 152 SF-767 U87MG HK301 BAH1 Gene region
16186 C C/T 4.5             D loop - Hypervariable segment 1, 7S DNA, membrane attachment site
16218 C C/T 16.9            
16224 T T/C           77.9   
16519 T T/C      53.7     55.8 58.2 51.2 52.9 D loop - 7S DNA, membrane attachment site
194 C T/C     4.1          D loop - Hypervariable segment 2, membrane attachment site
302 A A/C   16.4     41.5   39.9     
310 T T/C   5.6 5.0    17.5   6.0     
1386 T T/C 9.9             12s rRNA
2002 G G/A      11.1         16s rRNA
2130 A A/G   3.9 5.5 4.0   3.6 6.3 7.4     
2817 G G/A             11.7
3168 C C/T      3.7      3.7   
5752 A A/G   11.3 13.1 11.4   10.5 10.9 9.9      L strand replication origin
  1. Variants represent those that arise at a percentage frequency of or greater than 3%, after strict parameters were applied to exclude low quality reads from the final mapping of each full mitochondrial genome sequence. Variants that have not been previously reported are in bold.