Table 4 Regional distribution of filamentous PrP in a brain with A117V mutation (Case #17): semiquantitative scoring of white matter PrP filaments
Case #17: areas analysed | Density of filamentous PrP in white matter tracts in the region |
|---|---|
Anterior frontal F1-F2 | +++ |
Posterior frontal Superior frontal gyrus and pre motor cortex | ++ |
Temporal T1-T2 | +++ |
Temporal T2-T3 | +++ |
Tip of temporal lobe | +++ |
Parietal | ++ |
Occipital | ++ |
Anterior cingulate | +++ |
Hippocampus | +++ |
Amygdala | +++ |
Basal ganglia, ant. | +++ |
Basal ganglia, mid. | +++ |
Basal ganglia, post | ++ |
Thalamus with subthalamic nucleus | + |
Upper midbrain | +/++ |
Lower midbrain | + |
Pons | + |
Lower medulla | n.a. |
Cerebellum Vermis | + |
Cerebellum with dentate | - |
Cerebellum hemisphere | (+) |