Aβ-pathology in 15-month-old APP23 (a, c, e) and 3-month-old-APP48 mice (b, d, f). a: The APP23 mouse showed a high number of extracellular Aβ plaques detectable with an antibody raised against Aβ17-24 (arrows). Intracellular Aβ was negligible. b: In the 3-month-old APP48 mouse no extracellular Aβ-pathology was apparent. These animals showed intraneuronal dendritic threads (arrowheads) and somatic granules (lucent arrow) as well as intramicroglial Aβ-grains (arrows) detectable with anti-Aβ17-24 as previously published
. c: Amyloid plaques in APP23 mice did also contain N-terminal truncated and pyroglutamate modified AβN3pE (arrows). d: AβN3pE was also found in even 3-month-old APP48 mice in some neuritic threads (arrowheads). e: phosphorylated Aβ (pAβ) was detected in amyloid plaques in 15-month-old APP23 mice. f: In 3-month-old APP48 mice only single threads showed labeling with anti-pAβ. Calibration bar in b corresponds to: a, b = 30 μm; c = 80 μm; e = 60 μm; d, f = 20 μm.