NG2 cells, a new trail for Alzheimer’s disease mechanisms?

Table 2 Qualitative assessment of NG2 cell reactivity, Aβ plaques and glial nests in post-mortem brain tissue

NBB (No)	Amyloid plaque (score) ¹	Microglia nest (score) ²	NG2 cells (IHSI score) ³	Granular NG2 (%) ⁴
AD 2	(++++)	(++++)	(+) R	100
AD 37	(+++)	(++++)	(++) R	100
AD 12	(++++)	(++++)	(+) R	100
AD 78	(++)	(+)	(+++) R	50
ND 59	(++)	(++)	(++++) r	50
ND 39	(+)	(+)	(+++++) r	43
ND 49	(+)	(+++)	(++++)	37
ND 81	-	(++)	(+++)	5
ND 76	-	-	(++++)	5

¹ Plaque load is indicated either as (−) no Aβ plaques visible, or (+) low (++) moderate (+++) high and (++++) very high numbers of Aβ plaques.
² Microglia nests are indicated either as (−) no visible, or (+) low, (++) moderate and (++++) very high numbers of glial nests.
³ B5 IHSI intensity of NG2 cells is scored as (−) no visible NG2 cells (+) very weak, (++) weak, (+++) moderate (++++) strong and (+++++) very strong IHSI. R indicates the presence of more than 50% NG2 cells with reactive morphology. r indicate the presence of less than 50% reactive NG2 cells.
⁴ Percentage (%) cells with granular NG2 of total counted cells positive for NG2.stained with 9.2.27 and N143.8.

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