Tau pathology in Sw2 patient’s frontal (a-c and e) and temporal (d) cortex. a: Immunostaining for tau demonstrates abundant NTs, most prominent within Aβ plaques in layers 2 and 3, less numerous in layers 1, 4 and 6 and scarce in layer 5. Scattered small/atrophic neurons with NFTs are seen as dark spots (arrowheads). b and c: Consecutive sections demonstrate the accentuation of NTs within Aβx-42 positive plaques. A single plaque contains coarse DNs (arrow). The neuron within the large plaque (arrowhead) does not harbour a NFT. d: Neurons with NFTs (arrowheads) are predominantly located outside plaques. e: A neuron with an NFT (black arrowhead) is located outside the neighbouring plaque (asterisk) next to an hp-tau-negative neuron. f: Pyramidal neurons in CA1 of Sw1 patient’s hippocampus harbour prominent NFTs (arrowheads). Abundant NTs and a seemingly intact neuron (arrow) are noticeable in the surrounding tissue. g: Small granule cells in Sw2 patient’s dentate gyrus contain hp-tau-positive inclusions (arrowheads). Copious NTs and some coarser DNs (arrows) are seen in the adjoining hippocampal hilus. (bar in a 500 μm; bar in b 100 μm for b-d; bar in e 50 μm for e-g).