Figure 2From: Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups Histological features from simulated biopsies of neurodegenerative diseases diagnosed in the study. (a) Alzheimer’s disease illustrating the high density of tau positive neuropil threads, neuritic plaques and a neurofibrillary tangle (inset) (anti-tau). (b) Alzheimer’s disease revealing Aβ positive plaques in the cortex and evidence of amyloid angiopathy (anti-Aβ). (c) Multiple system atrophy (MSA) showing numerous p62 positive and α-synuclein positive (inset) oligodendroglial cytoplasmic inclusions in cerebral white matter. (d) Corticobasal degeneration showing a tau positive astrocytic plaque in the cortex (anti-tau). (e) Huntington’s disease revealing p62 positive intranuclear inclusions within neurones (anti-p62). (f) Frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP) showing TDP-43 positive neuronal cytoplasmic inclusions in the neocortex (anti-TDP-43). (g) Dementia with Lewy bodies illustrating α-synuclein positive Lewy bodies in the neocortex and a Lewy body at higher magnification (inset) (anti-α-synuclein). (h) Batten’s disease (neuronal ceroid lipfuscinosis type 2) showing enlarged neurones with excess granular cytoplasmic material (H&E). Main pictures (a), (b) show ×20 magnifications; (c), (d) (g) show ×40 magnifications, (f) (h) and inset for (a) show ×60 magnifications. (e) and inset for (c) show ×120 magnifications and inset for (g) shows × 100 magnification.Back to article page