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Table 4 Dysregulation of TDP-43 binding miRNAs in lymphoblastoid cell lines (LCLs) derived from sporadic and genetic ALS patients compared to LCLs of healthy controls

From: Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

miRNA

Sporadic ALS

ALS caused by mutation in

TDP-43

SOD1

FUS

C9ORF72

miR-132-5p

↓*

↓*

↔

↓**

↓*

miR-132-3p

↓*

↓*

↔

↓**

↓*

miR-143-5p

↓**

↓*

↓*

↓*

↓*

miR-143-3p

↓*

↓t

↓t

↓**

↓*

miR-574-5p

↓*

↓t

↔

↓*

↓**

miR-574-3p

↓**

↓t

↔

↓**

↓*

miR-558-3p

↔

↔

↔

↔

↔

miR-663a

↔

↔

↔

↓*

↔

let-7b

↔

↔

↔

↓**

↓*

  1. ↔: no change; ↓: downregulation; *,**: level of significance; t: trend.
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Acta Neuropathologica Communications

ISSN: 2051-5960

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