Figure 5
From: Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
Neuronal stress as estimated by heat shock-related damage associated with expression of 8-OH guanosine. Numbers of neurons expressing RNA/DNA oxidative damage was similar in the different APOE genotype groups (A-C). However, the extent of damage per neuron, as assessed by Stress Marq (8-OH guanosine) fluorescence intensity, was greater in patients with APOE ϵ4,4 than APOE ϵ2,2 or ϵ3,3 genotypes (80 ± 3 vs 55 ± 6 and 55 ± 6 arbitrary units, p = 0.001) (D).