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Table 1 Demographic and clinical characteristics of CPM patients

From: Evidence of aquaporin involvement in human central pontine myelinolysis

No. Age Sex AQP1/4 tissue Brief history Probable cause/
  (years)   immunoreactivity*   underlying cause of
1 56 M 0 Alcoholism; nausea and vomiting 1 week; hyponatremia, abnormal liver function tests; presented to Emergency Room in cardiorespiratory arrest. Rapid correction of hyponatremia
2 53 M 0 Depression and chronic obstructive pulmonary disease. Not seen for 4 days; found dehydrated and malnourished; drug and alcohol screen negative. Dehydration, malnutrition and hypernatremia
3 33 M 0 Cryptogenic cirrhosis with antitrypsin heterozygosity; orthotopic liver transplant and hyponatremia followed by progressive obtundation and seizures. Orthotopic liver transplant
4 45 M 0 Small-cell lung carcinoma, metastatic to liver; abnormal liver function tests; possible malnutrition; hyperkalemia; several syncopal episodes in preceding hours; presented with respiratory failure. SIAD secondary to small-cell lung carcinoma
5 24 F Hepatic failure and autoimmune thrombocytopenic purpura, 6 months; altered consciousness level and nonconvulsive status epilepticus 5 weeks before death; hypocalcemia, hyperammonemia and elevated liver enzymes. Hepatic failure and hypocalcemia
6 68 F Hypertension, obesity, diabetes mellitus, hyperuricemia and remote endometrial carcinoma (treated by resection, chemotherapy, and radiotherapy); presented with gangrene of the right fifth toe; generalized seizure followed by unresponsiveness. Diabetes mellitus type II
  1. *0 = absent; ↑ = increased.