Figure 1

AQP1, AQP4 and GFAP protein expression in human CPM lesions. ( a-d ) A demyelinated lesion in the central basis pontis ( a ) of a 56-year-old man with CPM in context of rapidly corrected hyponatremia shows loss of astrocytic AQP4 extending beyond the area of demyelination ( b ), loss of AQP1 ( c ), but retained GFAP ( d ); ( e-h ) A CPM lesion in the central basis pontis of a 53-year-old man with CPM and severe dehydration, malnutrition and hypernatremia shows relative preservation of myelin ( e ), loss of astrocytic AQP4 ( f ), AQP1 ( g ), but preserved GFAP ( h ); ( i-l ) A demyelinated lesion in the central basis pontis ( i ) of a 24-year-old woman with CPM in the context of hepatic failure and hypokalemia shows increased AQP4 ( j ), AQP1 ( k ) and GFAP expression ( l ); ( a, e, i ) PLP; ( b,f, j ) AQP4; ( c, g, k ) AQP1; ( d, h, l ) GFAP; (scale bar = 5 mm).