Figure 7From: Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination Quantification of circulating CRT in rat and human sera. Levels of CRT in rat sera (a) were measured by ELISA, revealing that CRT in EAE animals (n=5) was significantly (p<0.05) less than that in control animals (n=5). Testing for CRT in human sera (b) revealed significantly increased CRT in human MS sera (p<0.05), n=14) when compared to healthy controls (n=11). When data from MS samples was separated (c) according to whether or not individuals were undergoing treatment with nataluzimab, CRT was still significantly higher (p<0.01) in non-nataluzimab-treated patients (n=5), compared to samples from healthy controls (n=11). There was no significant difference in levels found in individuals on nataluzimab when compared to CRT in healthy controls.Back to article page