Figure 3

Dab2 deletion ameliorates EAE disease severity. a/b: EAE clinical scores of MOG-induced C57B/6 wild-type, Dab2 heterozygote and Dab2 knockout mice. a: Mice heterozygous for Dab2 have significantly repressed EAE disease scores from 14 days post-EAE induction (Mann–Whitney rank sum test; *p<0.05, **p<0.01, ***p<0.001) b: Dab2 knockout mice have significantly repressed EAE disease scores from 12 days post-EAE induction (Mann–Whitney rank sum test; *p<0.05, **p<0.01) c/d: Kaplan-Meier survival curves for wild-type, Dab2 heterozygote and Dab2 knockout mice. c: Figure shows that one hundred percent Dab2 heterozygote mice survived the EAE insult relative to eighty-one percent of wild-type mice (Chi-Square test, p<0.01). d: Figure shows that ninety-six percent of Dab2 knockout mice survived the EAE insult realtive to sixty-seven percent of wild-type mice (Chi-Square test, p<0.05). e/f: Serum phosphorylated neurofilament heavy chain (pNF-H) ELISA measure of axonal injury. e: Figure shows that mice heterozygous for Dab2 have a significantly lower concentration of pNF-H in their serum than wild-type mice (Two-tailed Student’s t-test p<0.01). f: Figure shows that Dab2 knockout mice have significantly less pNF-H in their serum than wild-type mice (Two-tailed Student’s t-test, p<0.01).