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  1. Research

    High plasticity of axonal pathology in Alzheimer’s disease mouse models

    Axonal dystrophies (AxDs) are swollen and tortuous neuronal processes that are associated with extracellular depositions of amyloid β (Aβ) and have been observed to contribute to synaptic alterations occurring...

    Lidia Blazquez-Llorca, Susana Valero-Freitag, Eva Ferreira Rodrigues, Ángel Merchán-Pérez, J. Rodrigo Rodríguez, Mario M. Dorostkar, Javier DeFelipe and Jochen Herms

    Acta Neuropathologica Communications 2017 5:14

    Published on: 7 February 2017

  2. Research

    Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains

    Mitochondria play a key role in common neurodegenerative diseases and contain their own genome: mtDNA. Common inherited polymorphic variants of mtDNA have been associated with several neurodegenerative disease...

    Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj…

    Acta Neuropathologica Communications 2017 5:13

    Published on: 2 February 2017

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:17

  3. Research

    Propagation of pathological α-synuclein in marmoset brain

    α-Synuclein is a defining, key component of Lewy bodies and Lewy neurites in Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), as well as glial cytoplasmic inclusions in multiple system atrophy (MS...

    Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga and Masato Hasegawa

    Acta Neuropathologica Communications 2017 5:12

    Published on: 2 February 2017

  4. Methodology article

    AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

    α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degenerat...

    Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari, Naomi P. Visanji, Jonathan M. Brotchie, Anthony E. Lang, Jens Volkmann and James B. Koprich

    Acta Neuropathologica Communications 2017 5:11

    Published on: 1 February 2017

  5. Research

    Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer’s disease

    MicroRNAs (miRNAs) are attractive molecules to utilize as one of the blood-based biomarkers for neurodegenerative disorders such as Alzheimer’s disease (AD) because miRNAs are relatively stable in biofluid, in...

    Norikazu Hara, Masataka Kikuchi, Akinori Miyashita, Hiroyuki Hatsuta, Yuko Saito, Kensaku Kasuga, Shigeo Murayama, Takeshi Ikeuchi and Ryozo Kuwano

    Acta Neuropathologica Communications 2017 5:10

    Published on: 31 January 2017

  6. Research

    Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency

    Mutations resulting in haploinsufficiency of progranulin (PGRN) cause frontotemporal lobar degeneration with TDP-43-positive inclusions (FTLD-TDP), a devastating neurodegenerative disease. Accumulating evidenc...

    Xiaolai Zhou, Lirong Sun, Owen Adam Brady, Kira A. Murphy and Fenghua Hu

    Acta Neuropathologica Communications 2017 5:9

    Published on: 26 January 2017

  7. Research

    Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease

    A major feature of Alzheimer’s disease (AD) is the loss of noradrenergic locus coeruleus (LC) projection neurons that mediate attention, memory, and arousal. However, the extent to which the LC projection syst...

    Sarah C. Kelly, Bin He, Sylvia E. Perez, Stephen D. Ginsberg, Elliott J. Mufson and Scott E. Counts

    Acta Neuropathologica Communications 2017 5:8

    Published on: 21 January 2017

  8. Research

    Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy

    Neurodegenerative disorders such as Parkinson’s Disease (PD), PD dementia (PDD) and Dementia with Lewy bodies (DLB) are characterized by progressive accumulation of α-synuclein (α-syn) in neurons. Recent studi...

    Brian Spencer, Elvira Valera, Edward Rockenstein, Cassia Overk, Michael Mante, Anthony Adame, Wagner Zago, Peter Seubert, Robin Barbour, Dale Schenk, Dora Games, Robert A. Rissman and Eliezer Masliah

    Acta Neuropathologica Communications 2017 5:7

    Published on: 13 January 2017

  9. Research

    Threonine175, a novel pathological phosphorylation site on tau protein linked to multiple tauopathies

    Microtubule associated protein tau (tau) deposition is associated with a spectrum of neurodegenerative diseases collectively termed tauopathies. We have previously shown that amyotrophic lateral sclerosis (ALS...

    Alexander J. Moszczynski, Wencheng Yang, Robert Hammond, Lee Cyn Ang and Michael J. Strong

    Acta Neuropathologica Communications 2017 5:6

    Published on: 11 January 2017

  10. Research

    Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease

    The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So f...

    Thomas Geuens, Vicky De Winter, Nicholas Rajan, Tilmann Achsel, Ligia Mateiu, Leonardo Almeida-Souza, Bob Asselbergh, Delphine Bouhy, Michaela Auer-Grumbach, Claudia Bagni and Vincent Timmerman

    Acta Neuropathologica Communications 2017 5:5

    Published on: 11 January 2017

  11. Research

    Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

    Neuropathological and genetic findings suggest that the presynaptic protein α-synuclein (aSyn) is involved in the pathogenesis of synucleinopathy disorders, including Parkinson’s disease (PD), dementia with Le...

    Daniel Ysselstein, Benjamin Dehay, Isabel M. Costantino, George P. McCabe, Matthew P. Frosch, Julia M. George, Erwan Bezard and Jean-Christophe Rochet

    Acta Neuropathologica Communications 2017 5:3

    Published on: 10 January 2017

  12. Research

    Expression site of P2RY12 in residential microglial cells in astrocytomas correlates with M1 and M2 marker expression and tumor grade

    The role of resident microglial cells in the pathogenesis and progression of glial tumors is still obscure mainly due to a lack of specific markers. Recently P2RY12, a P2 purinergic receptor, was introduced as...

    Changbin Zhu, Johan M. Kros, Marcel van der Weiden, PingPin Zheng, Caroline Cheng and Dana A. M. Mustafa

    Acta Neuropathologica Communications 2017 5:4

    Published on: 10 January 2017

  13. Research

    Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease

    Phosphorylated alpha-synuclein (p-α-syn) containing Lewy bodies (LBs) and Lewy neurites (LNs) are neuropathological hallmarks of Parkinson’s disease (PD) in the central nervous system (CNS). Since they have be...

    Martina Barrenschee, Dimitri Zorenkov, Martina Böttner, Christina Lange, François Cossais, Amelie Bernadette Scharf, Günther Deuschl, Susanne A. Schneider, Mark Ellrichmann, Annette Fritscher-Ravens and Thilo Wedel

    Acta Neuropathologica Communications 2017 5:1

    Published on: 5 January 2017

  14. Research

    Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

    Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progr...

    Elvira Valera, Brian Spencer, Jerel A. Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats and Eliezer Masliah

    Acta Neuropathologica Communications 2017 5:2

    Published on: 5 January 2017

  15. Research

    β-Amyloid triggers aberrant over-scaling of homeostatic synaptic plasticity

    The over-production of β-amyloid (Aβ) has been strongly correlated to neuronal dysfunction and altered synaptic plasticity in Alzheimer’s disease (AD). Accordingly, it has been proposed that disrupted synaptic...

    James Gilbert, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu and Heng-Ye Man

    Acta Neuropathologica Communications 2016 4:131

    Published on: 13 December 2016

    The Erratum to this article has been published in Acta Neuropathologica Communications 2017 5:20

  16. Research

    Post-mortem histopathology underlying β-amyloid PET imaging following flutemetamol F 18 injection

    In vivo imaging of fibrillar β-amyloid deposits may assist clinical diagnosis of Alzheimer’s disease (AD), aid treatment selection for patients, assist clinical trials of therapeutic drugs through subject sele...

    Milos D. Ikonomovic, Chris J. Buckley, Kerstin Heurling, Paul Sherwin, Paul A. Jones, Michelle Zanette, Chester A. Mathis, William E. Klunk, Aruna Chakrabarty, James Ironside, Azzam Ismail, Colin Smith, Dietmar R. Thal, Thomas G. Beach, Gill Farrar and Adrian P. L. Smith

    Acta Neuropathologica Communications 2016 4:130

    Published on: 12 December 2016

  17. Retraction Note

    Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD

    Renate K. Hukema, Fréderike W. Riemslagh, Shamiram Melhem, Herma C. van der Linde, Lies-Anne W. F. M. Severijnen, Dieter Edbauer, Alex Maas, Nicolas Charlet-Berguerand, Rob Willemsen and John C. van Swieten

    Acta Neuropathologica Communications 2016 4:129

    Published on: 9 December 2016

    The original article was published in Acta Neuropathologica Communications 2014 2:166

  18. Research

    The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

    α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications a...

    Diana F. Lázaro, Mariana Castro Dias, Anita Carija, Susanna Navarro, Carolina Silva Madaleno, Sandra Tenreiro, Salvador Ventura and Tiago F. Outeiro

    Acta Neuropathologica Communications 2016 4:128

    Published on: 9 December 2016

  19. Research

    Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

    Abnormally elevated hippocampal Caspase-6 (Casp6) activity is intimately associated with age-related cognitive impairment in humans and in mice. In humans, these high levels of Casp6 activity are initially loc...

    Benedicte Foveau, Steffen Albrecht, David A. Bennett, José A. Correa and Andrea C. LeBlanc

    Acta Neuropathologica Communications 2016 4:127

    Published on: 8 December 2016

  20. Research

    Dopamine-2 receptor extracellular N-terminus regulates receptor surface availability and is the target of human pathogenic antibodies from children with movement and psychiatric disorders

    Anti-Dopamine-2 receptor (D2R) antibodies have been recently identified in a subgroup of children with autoimmune movement and psychiatric disorders, however the epitope(s) and mechanism of pathogenicity remai...

    Nese Sinmaz, Fiona Tea, Deepti Pilli, Alicia Zou, Mazen Amatoury, Tina Nguyen, Vera Merheb, Sudarshini Ramanathan, Sandra T. Cooper, Russell C. Dale and Fabienne Brilot

    Acta Neuropathologica Communications 2016 4:126

    Published on: 1 December 2016

  21. Research

    The identification of human pituitary adenoma-initiating cells

    Classified as benign central nervous system (CNS) tumors, pituitary adenomas account for 10% of diagnosed intracranial neoplasms. Although surgery is often curative, patients with invasive macroadenomas contin...

    Branavan Manoranjan, Sujeivan Mahendram, Saleh A. Almenawer, Chitra Venugopal, Nicole McFarlane, Robin Hallett, Thusyanth Vijayakumar, Almunder Algird, Naresh K. Murty, Doron D. Sommer, John P. Provias, Kesava Reddy and Sheila K. Singh

    Acta Neuropathologica Communications 2016 4:125

    Published on: 28 November 2016

  22. Research

    Neuronal and glial changes in the brain resulting from explosive blast in an experimental model

    Mild traumatic brain injury (mTBI) is the signature injury in warfighters exposed to explosive blasts. The pathology underlying mTBI is poorly understood, as this condition is rarely fatal and thus postmortem ...

    James A. Goodrich, Jung H. Kim, Robert Situ, Wesley Taylor, Ted Westmoreland, Fu Du, Steven Parks, Geoffrey Ling, Jung Y. Hwang, Amedeo Rapuano, Faris A. Bandak and Nihal C. de Lanerolle

    Acta Neuropathologica Communications 2016 4:124

    Published on: 24 November 2016

  23. Research

    Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

    Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of upper and lower motor neurons. Mutations in the gene encoding the nuclear matrix protein Matrin 3 have been found in familial ...

    Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, Maurice S. Swanson, Lucia Notterpek, David R. Borchelt and Jada Lewis

    Acta Neuropathologica Communications 2016 4:122

    Published on: 18 November 2016

  24. Review

    Review of RyR1 pathway and associated pathomechanisms

    Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein dysfunction that manifests clinically...

    Jessica W. Witherspoon and Katherine G. Meilleur

    Acta Neuropathologica Communications 2016 4:121

    Published on: 17 November 2016

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