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  1. The blood-brain barrier (BBB) is damaged in tauopathies, including progressive supranuclear palsy (PSP) and Alzheimer’s disease (AD), which is thought to contribute to pathogenesis later in the disease course....

    Authors: Laura J Blair, Haley D Frauen, Bo Zhang, Bryce A Nordhues, Sara Bijan, Yen-Chi Lin, Frank Zamudio, Lidice D Hernandez, Jonathan J Sabbagh, Maj-Linda B Selenica and Chad A Dickey
    Citation: Acta Neuropathologica Communications 2015 3:8
  2. α-Synuclein (α-syn) is a key protein in Parkinson’s disease (PD), and one of its phosphorylated forms, pS129, is higher in PD patients than healthy controls. However, few studies have examined its levels in lo...

    Authors: Tessandra Stewart, Vesna Sossi, Jan O Aasly, Zbigniew K Wszolek, Ryan J Uitti, Kazuko Hasegawa, Teruo Yokoyama, Cyrus P Zabetian, James B Leverenz, Alexander Jon Stoessl, Yu Wang, Carmen Ginghina, Changqin Liu, Kevin C Cain, Peggy Auinger, Un Jung Kang…
    Citation: Acta Neuropathologica Communications 2015 3:7
  3. The Lysosomal Associated Membrane Protein type-2 (LAMP-2) is an abundant lysosomal membrane protein with an important role in immunity, macroautophagy (MA) and chaperone-mediated autophagy (CMA). Mutations wit...

    Authors: Michelle Rothaug, Stijn Stroobants, Michaela Schweizer, Judith Peters, Friederike Zunke, Mirka Allerding, Rudi D’Hooge, Paul Saftig and Judith Blanz
    Citation: Acta Neuropathologica Communications 2015 3:6
  4. Amyotrophic lateral sclerosis (ALS) is an adult-onset disease characterized by the selective degeneration of motor neurons in the brain and spinal cord progressively leading to paralysis and death. Current dia...

    Authors: Bastien Paré, Lydia Touzel-Deschênes, Rémy Lamontagne, Marie-Soleil Lamarre, François-Dominique Scott, Hélène T Khuong, Patrick A Dion, Jean-Pierre Bouchard, Peter Gould, Guy A Rouleau, Nicolas Dupré, François Berthod and François Gros-Louis
    Citation: Acta Neuropathologica Communications 2015 3:5
  5. The R132H mutation of cytosolic isocitrate dehydrogenase (IDH1) is present in the majority of low grade gliomas. Immunotherapy in these tumors has an interesting, still unexploited, therapeutic potential, as t...

    Authors: Serena Pellegatta, Lorella Valletta, Cristina Corbetta, Monica Patanè, Ileana Zucca, Federico Riccardi Sirtori, Maria Grazia Bruzzone, Gianpaolo Fogliatto, Antonella Isacchi, Bianca Pollo and Gaetano Finocchiaro
    Citation: Acta Neuropathologica Communications 2015 3:4
  6. The molecular mechanisms underlying autistic behaviors remain to be elucidated. Mutations in genes linked to autism adversely affect molecules regulating dendritic spine formation, function and plasticity, and...

    Authors: Chiara Nicolini, Younghee Ahn, Bernadeta Michalski, Jong M Rho and Margaret Fahnestock
    Citation: Acta Neuropathologica Communications 2015 3:3
  7. Characterization of the type and topography of structural changes and their alterations throughout the lifespan of individuals with autism is essential for understanding the mechanisms contributing to the auti...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Janusz Frackowiak, Bozena Mazur Kolecka, Teresa Wierzba-Bobrowicz, Eric London, Thomas Wisniewski, Patrick R Hof and W Ted Brown
    Citation: Acta Neuropathologica Communications 2015 3:2
  8. Anti-acetylcholine receptor (AChR) autoantibodies target muscles in spontaneous human myasthenia gravis (MG) and its induced experimental autoimmune model MG (EAMG). The aim of this study was to identify novel...

    Authors: Marie Maurer, Sylvain Bougoin, Tali Feferman, Mélinée Frenkian, Jacky Bismuth, Vincent Mouly, Geraldine Clairac, Socrates Tzartos, Elie Fadel, Bruno Eymard, Sara Fuchs, Miriam C Souroujon and Sonia Berrih-Aknin
    Citation: Acta Neuropathologica Communications 2015 3:1
  9. Long before synaptic loss occurs in Alzheimer’s disease significant harbingers of disease may be detected at the functional level. Here we examined if synaptic long-term potentiation is selectively disrupted p...

    Authors: Yingjie Qi, Igor Klyubin, Sarah C Harney, NengWei Hu, William K Cullen, Marianne K Grant, Julia Steffen, Edward N Wilson, Sonia Do Carmo, Stefan Remy, Martin Fuhrmann, Karen H Ashe, A Claudio Cuello and Michael J Rowan
    Citation: Acta Neuropathologica Communications 2014 2:175
  10. TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related ra...

    Authors: Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Dianna C Martin, Pedro Castelo-Branco, Cindy H Zhang, Michael Fraser, Ken Tse, Raymond Poon, David JH Shih, Berivan Baskin, Peter N Ray, Eric Bouffet, Peter Dirks, Andre O von Bueren, Elke Pfaff…
    Citation: Acta Neuropathologica Communications 2014 2:174
  11. Amyotrophic lateral sclerosis is a neurodegenerative disease characterized clinically by motor symptoms including limb weakness, dysarthria, dysphagia, and respiratory compromise, and pathologically by inclusi...

    Authors: Matthew D Cykowski, Hidehiro Takei, Paul E Schulz, Stanley H Appel and Suzanne Z Powell
    Citation: Acta Neuropathologica Communications 2014 2:171
  12. Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma un...

    Authors: Ganesh M Shankar, Amaro Taylor-Weiner, Nina Lelic, Robert T Jones, James C Kim, Joshua M Francis, Malak Abedalthagafi, Lawrence F Borges, Jean-Valery Coumans, William T Curry, Brian V Nahed, John H Shin, Sun Ha Paek, Sung-Hye Park, Chip Stewart, Michael S Lawrence…
    Citation: Acta Neuropathologica Communications 2014 2:167
  13. Huntington’s disease (HD) disturbs glucose metabolism in the brain by poorly understood mechanisms. HD neurons have defective glucose uptake, which is attenuated upon enhancing rab11 activity. Rab11 regulates ...

    Authors: Hollis McClory, Dana Williams, Ellen Sapp, Leah W Gatune, Ping Wang, Marian DiFiglia and Xueyi Li
    Citation: Acta Neuropathologica Communications 2014 2:179
  14. Clinical outcome of children with malignant glioma remains dismal. Here, we examined the role of over-expressed BMI1, a regulator of stem cell self-renewal, in sustaining tumor formation in pediatric glioma st...

    Authors: Patricia A Baxter, Qi Lin, Hua Mao, Mari Kogiso, Xiumei Zhao, Zhigang Liu, Yulun Huang, Horatiu Voicu, Sivashankarappa Gurusiddappa, Jack M Su, Adekunle M Adesina, Laszlo Perlaky, Robert C Dauser, Hon-chiu Eastwood Leung, Karin M Muraszko, Jason A Heth…
    Citation: Acta Neuropathologica Communications 2014 2:160
  15. Transthyretin V30M mutation is the most common variant leading to Familial Amyloidotic Polyneuropathy. In this genetic disorder, Transthyretin accumulates preferentially in the extracellular matrix of peripher...

    Authors: Nádia Pereira Gonçalves, Susete Costelha and Maria João Saraiva
    Citation: Acta Neuropathologica Communications 2014 2:177
  16. Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders. The progressive remodeling of brain microvessels due to arterial hypertension or other vascular risk factors causes sub...

    Authors: Daniel Kaiser, Gesa Weise, Karoline Möller, Johanna Scheibe, Claudia Pösel, Sebastian Baasch, Matthias Gawlitza, Donald Lobsien, Kai Diederich, Jens Minnerup, Alexander Kranz, Johannes Boltze and Daniel-Christoph Wagner
    Citation: Acta Neuropathologica Communications 2014 2:169
  17. MicroRNAs (miRNAs) are noncoding small RNAs that regulate gene expression. This study investigated whether formalin-fixed paraffin-embedded (FFPE) specimens from postmortem cases of neurodegenerative disorders...

    Authors: Koichi Wakabayashi, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Jun Utsumi and Hidenao Sasaki
    Citation: Acta Neuropathologica Communications 2014 2:173
  18. Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in th...

    Authors: Safa Al-Sarraj, Andrew King, Matt Cleveland, Pierre-François Pradat, Andrea Corse, Jeffrey D Rothstein, Peter Nigel Leigh, Bams Abila, Stewart Bates, Jens Wurthner and Vincent Meininger
    Citation: Acta Neuropathologica Communications 2014 2:165
  19. Parkinson’s disease (PD) is not only characterized by motor disturbances but also, by cognitive, sensory, psychiatric and autonomic dysfunction. It has been proposed that some of these symptoms might be relate...

    Authors: Rosa María Giráldez-Pérez, Mónica Antolín-Vallespín, María Dolores Muñoz and Amelia Sánchez-Capelo
    Citation: Acta Neuropathologica Communications 2014 2:176
  20. Authors: Renate K Hukema, Fréderike W Riemslagh, Shamiram Melhem, Herma C van der Linde, Lies-Anne WFM Severijnen, Dieter Edbauer, Alex Maas, Nicolas Charlet-Berguerand, Rob Willemsen and John C van Swieten
    Citation: Acta Neuropathologica Communications 2014 2:166

    The Retraction Note to this article has been published in Acta Neuropathologica Communications 2016 4:129

  21. Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS lesions remyelinates completely. Enhancing remyelination is, therefore, a major aim of future MS therapies. He...

    Authors: Hema Mohan, Anita Friese, Stefanie Albrecht, Markus Krumbholz, Christina L Elliott, Ariel Arthur, Ramesh Menon, Cinthia Farina, Andreas Junker, Christine Stadelmann, Susan C Barnett, Inge Huitinga, Hartmut Wekerle, Reinhard Hohlfeld, Hans Lassmann, Tanja Kuhlmann…
    Citation: Acta Neuropathologica Communications 2014 2:178
  22. Pretangles are defined under the light microscope as diffuse and granular tau immunoreactivity in neurons in tissue from patients with Alzheimer disease (AD) or corticobasal degeneration (CBD) and are consider...

    Authors: Shinsui Tatsumi, Toshiki Uchihara, Ikuko Aiba, Yasushi Iwasaki, Maya Mimuro, Ryosuke Takahashi and Mari Yoshida
    Citation: Acta Neuropathologica Communications 2014 2:161
  23. Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later ...

    Authors: Takashi Ayaki, Hidefumi Ito, Hiroko Fukushima, Takeshi Inoue, Takayuki Kondo, Akito Ikemoto, Takeshi Asano, Akemi Shodai, Takuji Fujita, Satoshi Fukui, Hiroyuki Morino, Satoshi Nakano, Hirofumi Kusaka, Hirofumi Yamashita, Masafumi Ihara, Riki Matsumoto…
    Citation: Acta Neuropathologica Communications 2014 2:172
  24. Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondri...

    Authors: Philip G Nijland, Maarten E Witte, Bert van het Hof, Susanne van der Pol, Jan Bauer, Hans Lassmann, Paul van der Valk, Helga E de Vries and Jack van Horssen
    Citation: Acta Neuropathologica Communications 2014 2:170
  25. Kallikrein-6 and calpain-1 are amongst a small group of proteases that degrade α-synuclein. We have explored the possibility that reduction in the level or activity of these enzymes contributes to the accumula...

    Authors: J Scott Miners, Ruth Renfrew, Marta Swirski and Seth Love
    Citation: Acta Neuropathologica Communications 2014 2:164
  26. Regulatory T cells are crucial in controlling various functions of effector T cells during experimental autoimmune encephalomyelitis. While regulatory T cells are reported to exert their immunomodulatory effec...

    Authors: Michail Koutrolos, Kerstin Berer, Naoto Kawakami, Hartmut Wekerle and Gurumoorthy Krishnamoorthy
    Citation: Acta Neuropathologica Communications 2014 2:163
  27. Foetal akinesia deformation sequence syndrome (FADS) is a genetically heterogeneous disorder characterised by the combination of foetal akinesia and developmental defects which may include pterygia (joint webb...

    Authors: Arthur B McKie, Atif Alsaedi, Julie Vogt, Kyra E Stuurman, Marjan M Weiss, Hassan Shakeel, Louise Tee, Neil V Morgan, Peter G J Nikkels, Gijs van Haaften, Soo-Mi Park, Jasper J van der Smagt, Marianna Bugiani and Eamonn R Maher
    Citation: Acta Neuropathologica Communications 2014 2:148
  28. Blast injury to brain, a hundred-year old problem with poorly characterized neuropathology, has resurfaced as health concern in recent deployments in Iraq and Afghanistan. To characterize the neuropathology of...

    Authors: Jiwon Ryu, Iren Horkayne-Szakaly, Leyan Xu, Olga Pletnikova, Francesco Leri, Charles Eberhart, Juan C Troncoso and Vassilis E Koliatsos
    Citation: Acta Neuropathologica Communications 2014 2:153
  29. Early onset isolated dystonia (DYT1) is linked to a three base pair deletion (ΔGAG) mutation in the TOR1A gene. Clinical manifestation includes intermittent muscle contraction leading to twisting movements or abn...

    Authors: Reema Paudel, Aoife Kiely, Abi Li, Tammaryn Lashley, Rina Bandopadhyay, John Hardy, Hyder A Jinnah, Kailash Bhatia, Henry Houlden and Janice L Holton
    Citation: Acta Neuropathologica Communications 2014 2:159
  30. Genetic polymorphisms in Solute carrier family 1 (glial high affinity glutamate transporter), member 2 (SLC1A2) have been linked with essential tremor. SLC1A2 encodes excitatory amino acid transporter type 2 (EAA...

    Authors: Michelle Lee, Melody M Cheng, Chi-Ying Lin, Elan D Louis, Phyllis L Faust and Sheng-Han Kuo
    Citation: Acta Neuropathologica Communications 2014 2:157
  31. Parkinson's disease (PD) is the most prevalent neurodegenerative motor disorder. The neuropathology is characterized by intraneuronal protein aggregates of α-synuclein and progressive degeneration of dopaminer...

    Authors: Antonio Boza-Serrano, Juan F Reyes, Nolwen L Rey, Hakon Leffler, Luc Bousset, Ulf Nilsson, Patrik Brundin, Jose Luis Venero, Miguel Angel Burguillos and Tomas Deierborg
    Citation: Acta Neuropathologica Communications 2014 2:156
  32. Addiction involves long-lasting maladaptive changes including development of disruptive drug-stimuli associations. Nicotine-induced neuroplasticity underlies the development of tobacco addiction but also, in r...

    Authors: Susanna Molas, Thomas Gener, Jofre Güell, Mairena Martín, Inmaculada Ballesteros-Yáñez, Maria V Sanchez-Vives and Mara Dierssen
    Citation: Acta Neuropathologica Communications 2014 2:147
  33. Previous magnetic resonance spectroscopy (MRS) and mass spectroscopy studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a pow...

    Authors: Manabu Natsumeda, Hironaka Igarashi, Toshiharu Nomura, Ryosuke Ogura, Yoshihiro Tsukamoto, Tsutomu Kobayashi, Hiroshi Aoki, Kouichirou Okamoto, Akiyoshi Kakita, Hitoshi Takahashi, Tsutomu Nakada and Yukihiko Fujii
    Citation: Acta Neuropathologica Communications 2014 2:158
  34. Multiple system atrophy (MSA) is a rapidly-progressive neurodegenerative disease characterized by parkinsonism, cerebellar ataxia and autonomic failure. A pathological hallmark of MSA is the presence of α-synu...

    Authors: Anthony S Don, Jen-Hsiang T Hsiao, Jonathan M Bleasel, Timothy A Couttas, Glenda M Halliday and Woojin Scott Kim
    Citation: Acta Neuropathologica Communications 2014 2:150
  35. To assess the value of major histocompatibility complex (MHC) class II antigen (HLA-DR) expression to distinguish anti-synthetase myopathy (ASM) from dermatomyositis (DM).

    Authors: Jessie Aouizerate, Marie De Antonio, Guillaume Bassez, Romain K Gherardi, Francis Berenbaum, Loïc Guillevin, Alice Berezne, Dominique Valeyre, Thierry Maisonobe, Odile Dubourg, Anne Cosnes, Olivier Benveniste and François Jérôme Authier
    Citation: Acta Neuropathologica Communications 2014 2:154
  36. Variably protease sensitive prionopathy (VPSPr) is a recently described, sporadic human prion disease that is pathologically and biochemically distinct from the currently recognised sporadic Creutzfeldt-Jakob ...

    Authors: Alexander H Peden, Deep P Sarode, Carl R Mulholland, Marcelo A Barria, Diane L Ritchie, James W Ironside and Mark W Head
    Citation: Acta Neuropathologica Communications 2014 2:152
  37. Hypersynchronicity of neuronal brain circuits is a feature of Alzheimer’s disease (AD). Mouse models of AD expressing mutated forms of the amyloid-β precursor protein (APP), a central protein involved in AD pa...

    Authors: Arne A Ittner, Amadeus Gladbach, Josefine Bertz, Lisa S Suh and Lars M Ittner
    Citation: Acta Neuropathologica Communications 2014 2:149
  38. The accumulation of neurofibrillary tangles in Alzheimer’s disease (AD) propagates with characteristic spatiotemporal patterns which follow brain network connections, implying trans-synaptic transmission of ta...

    Authors: Hwan-Ching Tai, Bo Y Wang, Alberto Serrano-Pozo, Matthew P Frosch, Tara L Spires-Jones and Bradley T Hyman
    Citation: Acta Neuropathologica Communications 2014 2:146
  39. A 28-month female with a clinical diagnosis of neurocutaneous melanosis and numerous intracranial abnormalities (including a right choroid plexus tumor and left hemimegalencephaly) presented with a rapidly exp...

    Authors: Francis Shih, Stephen Yip, Patrick J McDonald, Albert E Chudley and Marc R Del Bigio
    Citation: Acta Neuropathologica Communications 2014 2:140
  40. High-grade Brainstem Glioma (BSG), also known as Diffuse Intrinsic Pontine Glioma (DIPG), is an incurable pediatric brain cancer. Increasing evidence supports the existence of regional differences in gliomagen...

    Authors: Katherine L. Misuraca, Kelly L. Barton, Alexander Chung, Alexander K. Diaz, Simon J. Conway, David L. Corcoran, Suzanne J. Baker and Oren J. Becher
    Citation: Acta Neuropathologica Communications 2014 2:134
  41. Traumatic brain injury (TBI), a significant cause of death and disability, causes, as in any injury, an acute, innate immune response. A key component in the transition between innate and adaptive immunity is ...

    Authors: Richard P Tobin, Sanjib Mukherjee, Jessica M Kain, Susannah K Rogers, Stephanie K Henderson, Heather L Motal, M Karen Newell Rogers and Lee A Shapiro
    Citation: Acta Neuropathologica Communications 2014 2:143
  42. Kinesin family member 21b (kif21b) is one of the few multiple sclerosis (MS) risk genes with a presumed central nervous system function. Kif21b belongs to the kinesin family, proteins involved in intracellular...

    Authors: Karim L Kreft, Marjan van Meurs, Annet F Wierenga-Wolf, Marie-Jose Melief, Miriam E van Strien, Elly M Hol, Ben A Oostra, Jon D Laman and Rogier Q Hintzen
    Citation: Acta Neuropathologica Communications 2014 2:144
  43. This paper summarizes pathological changes that affect microglial cells in the human brain during aging and in aging-related neurodegenerative diseases, primarily Alzheimer’s disease (AD). It also provides exa...

    Authors: Wolfgang J Streit, Qing-Shan Xue, Jasmin Tischer and Ingo Bechmann
    Citation: Acta Neuropathologica Communications 2014 2:142
  44. Recent histopathological studies have shown that neurodegenerative processes in Alzheimer's and Parkinson's Disease develop along neuronal networks and that hallmarks could propagate trans-synaptically through...

    Authors: Bérangére Deleglise, Sebastien Magnifico, Eric Duplus, Pauline Vaur, Vanessa Soubeyre, Morgane Belle, Maeva Vignes, Jean-Louis Viovy, Etienne Jacotot, Jean-Michel Peyrin and Bernard Brugg
    Citation: Acta Neuropathologica Communications 2014 2:145
  45. A total of 38 brain cytoarchitectonic subdivisions, representing subcortical and cortical structures, cerebellum, and brainstem, were examined in 4- to 60-year-old subjects diagnosed with autism and control su...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Ira L Cohen, Eric London, Thomas Wisniewski and William Ted Brown
    Citation: Acta Neuropathologica Communications 2014 2:141
  46. Mutations in THAP1 result in dystonia type 6, with partial penetrance and variable phenotype. The goal of this study was to examine the nature and expression pattern of the protein product(s) of the Thap1 tran...

    Authors: Maitane Ortiz-Virumbrales, Marta Ruiz, Eugene Hone, Georgia Dolios, Rong Wang, Andrika Morant, Jessica Kottwitz, Laurie J Ozelius, Sam Gandy and Michelle E Ehrlich
    Citation: Acta Neuropathologica Communications 2014 2:139
  47. Axial myopathy can be the underlying cause of rapidly progressive adult-onset scoliosis; however, the pathogenesis of this disorder remains poorly understood. Here we present a case of a 69-year old woman with...

    Authors: Annie Hiniker, Lee-Jun Wong, Sigurd Berven, Cavatina K Truong, Adekunle M Adesina and Marta Margeta
    Citation: Acta Neuropathologica Communications 2014 2:137

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