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  1. Intraneuronal neurofibrillary tangles (NFTs) – a characteristic pathological feature of Alzheimer’s and several other neurodegenerative diseases – are considered a major target for drug development. Tangle loa...

    Authors: Nikita Rudinskiy, Jonathan M Hawkes, Susanne Wegmann, Kishore V Kuchibhotla, Alona Muzikansky, Rebecca A Betensky, Tara L Spires-Jones and Bradley T Hyman

    Citation: Acta Neuropathologica Communications 2014 2:63

    Content type: Research

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  2. Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology of cancer pain is poorly understood. Adenosine triphosphate (ATP) and the ATP ionotropic receptor subunits, P2X2 and P2...

    Authors: Yi Ye, Kentaro Ono, Daniel G Bernabé, Chi T Viet, Victoria Pickering, John C Dolan, Markus Hardt, Anthony P Ford and Brian L Schmidt

    Citation: Acta Neuropathologica Communications 2014 2:62

    Content type: Research

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  3. Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer’s disease (AD) pathology, capable of triggering neuroinflammation, tau hyperp...

    Authors: M Florencia Iulita, Simon Allard, Luise Richter, Lisa-Marie Munter, Adriana Ducatenzeiler, Christoph Weise, Sonia Do Carmo, William L Klein, Gerhard Multhaup and A Claudio Cuello

    Citation: Acta Neuropathologica Communications 2014 2:61

    Content type: Research

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  4. The pathogenesis of heart failure (HF) in diabetic individuals, called “diabetic cardiomyopathy”, is only partially understood. Alterations in the cardiac autonomic nervous system due to oxidative stress have ...

    Authors: Chantalle E Menard, Melanie Durston, Elena Zherebitskaya, Darrell R Smith, Darren Freed, Gordon W Glazner, Ganghong Tian, Paul Fernyhough and Rakesh C Arora

    Citation: Acta Neuropathologica Communications 2014 2:60

    Content type: Research

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  5. Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encodin...

    Authors: Sama Ahsan, Eric H Raabe, Michael C Haffner, Ajay Vaghasia, Katherine E Warren, Martha Quezado, Leomar Y Ballester, Javad Nazarian, Charles G Eberhart and Fausto J Rodriguez

    Citation: Acta Neuropathologica Communications 2014 2:59

    Content type: Research

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  6. Mutations in isocitrate dehydrogenase genes IDH1 or IDH2 are frequent in glioma, and IDH mutation status is a strong diagnostic and prognostic marker. Current IDH mutation screening is performed with an immunohis...

    Authors: Aurélie Catteau, Hélène Girardi, Florence Monville, Cécile Poggionovo, Sabrina Carpentier, Véronique Frayssinet, Jesse Voss, Robert Jenkins, Blandine Boisselier, Karima Mokhtari, Marc Sanson, Hélène Peyro-Saint-Paul and Caterina Giannini

    Citation: Acta Neuropathologica Communications 2014 2:58

    Content type: Methodology article

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  7. Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumve...

    Authors: Ramadhan T Othman, Ioanna Kimishi, Tracey D Bradshaw, Lisa CD Storer, Andrey Korshunov, Stefan M Pfister, Richard G Grundy, Ian D Kerr and Beth Coyle

    Citation: Acta Neuropathologica Communications 2014 2:57

    Content type: Research

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  8. Pathological aggregation of the microtubule-associated protein tau and subsequent accumulation of neurofibrillary tangles (NFTs) or other tau-containing inclusions are defining histopathological features of ma...

    Authors: Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson and Rakez Kayed

    Citation: Acta Neuropathologica Communications 2014 2:56

    Content type: Research

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  9. Greater than 160 missense mutations in copper-zinc superoxide dismutase-1 (SOD1) can cause amyotrophic lateral sclerosis (ALS). These mutations produce conformational changes that reveal novel antibody binding ep...

    Authors: Jacob I Ayers, Guilian Xu, Olga Pletnikova, Juan C Troncoso, P John Hart and David R Borchelt

    Citation: Acta Neuropathologica Communications 2014 2:55

    Content type: Research

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  10. The neuronal ceroid lipofuscinoses constitute a group of fatal inherited lysosomal storage diseases that manifest in profound neurodegeneration in the CNS. Visual impairment usually is an early symptom and sel...

    Authors: Janos Groh, David Stadler, Mathias Buttmann and Rudolf Martini

    Citation: Acta Neuropathologica Communications 2014 2:54

    Content type: Methodology article

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  11. Inflammation and complement activation are firmly implicated in the pathology of multiple sclerosis; however, the extent and nature of their involvement in specific pathological processes such as axonal damage...

    Authors: Gillian Ingram, Sam Loveless, Owain W Howell, Svetlana Hakobyan, Bethan Dancey, Claire L Harris, Neil P Robertson, James W Neal and B Paul Morgan

    Citation: Acta Neuropathologica Communications 2014 2:53

    Content type: Research

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  12. Acute hemorrhagic leukoencephalitis (AHL) is a fulminant demyelinating disease of unknown etiology. Most cases are fatal within one week from onset. AHL pathology varies with the acuteness of disease. Hemorrha...

    Authors: Christopher A Robinson, Reginald C Adiele, Mylyne Tham, Claudia F Lucchinetti and Bogdan FGh Popescu

    Citation: Acta Neuropathologica Communications 2014 2:52

    Content type: Case report

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  13. Pyramidal (glutamatergic) neurons and interneurons are morphologically and functionally well defined in the central nervous system. Although it is known that glutamatergic neurons undergo immediate cell death ...

    Authors: Prabhu Ramamoorthy and Honglian Shi

    Citation: Acta Neuropathologica Communications 2014 2:51

    Content type: Research

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  14. Extensive research on p62 has established its role in oxidative stress, protein degradation and in several diseases such as Paget’s disease of the bone, frontotemporal lobar degeneration and amyotrophic latera...

    Authors: Kunikazu Tanji, Yasuo Miki, Taku Ozaki, Atsushi Maruyama, Hidemi Yoshida, Junsei Mimura, Tomoh Matsumiya, Fumiaki Mori, Tadaatsu Imaizumi, Ken Itoh, Akiyoshi Kakita, Hitoshi Takahashi and Koichi Wakabayashi

    Citation: Acta Neuropathologica Communications 2014 2:50

    Content type: Research

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  15. Small vessel disease (SVD) of the brain is a leading cause of age- and hypertension-related cognitive decline and disability. Cerebral white matter changes are a consistent manifestation of SVD on neuroimaging...

    Authors: Emmanuel Cognat, Sabine Cleophax, Valérie Domenga-Denier and Anne Joutel

    Citation: Acta Neuropathologica Communications 2014 2:49

    Content type: Research

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  17. The BTB-KELCH protein Gigaxonin plays key roles in sustaining neuron survival and cytoskeleton architecture. Indeed, recessive mutations in the Gigaxonin-encoding gene cause Giant Axonal Neuropathy (GAN), a se...

    Authors: Alexia Boizot, Yasmina Talmat-Amar, Deborah Morrogh, Nancy L Kuntz, Cecile Halbert, Brigitte Chabrol, Henry Houlden, Tanya Stojkovic, Brenda A Schulman, Bernd Rautenstrauss and Pascale Bomont

    Citation: Acta Neuropathologica Communications 2014 2:47

    Content type: Research

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  18. PET imaging of amyloid-β (Aβ) in vivo holds promise for aiding in earlier diagnosis and intervention in Alzheimer’s disease (AD) and mild cognitive impairment. AD-like Aβ pathology is a common comorbidity in p...

    Authors: Ville Leinonen, Juha O Rinne, Dean F Wong, David A Wolk, John Q Trojanowski, Paul F Sherwin, Adrian Smith, Kerstin Heurling, Mandy Su and Igor D Grachev

    Citation: Acta Neuropathologica Communications 2014 2:46

    Content type: Research

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  19. Type II focal cortical dysplasias (FCDs) are malformations of cortical development characterised by the disorganisation of the normal neocortical structure and the presence of dysmorphic neurons (DNs) and ball...

    Authors: Laura Rossini, Valentina Medici, Laura Tassi, Francesco Cardinale, Giovanni Tringali, Manuela Bramerio, Flavio Villani, Roberto Spreafico and Rita Garbelli

    Citation: Acta Neuropathologica Communications 2014 2:45

    Content type: Research

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  20. Nemaline myopathy (NM) is a rare congenital myopathy characterised by hypotonia, muscle weakness, and often skeletal muscle deformities with the presence of nemaline bodies (rods) in the muscle biopsy. The neb...

    Authors: Edoardo Malfatti, Vilma-Lotta Lehtokari, Johann Böhm, Josine M De Winter, Ursula Schäffer, Brigitte Estournet, Susana Quijano-Roy, Soledad Monges, Fabiana Lubieniecki, Remi Bellance, Mai Thao Viou, Angéline Madelaine, Bin Wu, Ana Lía Taratuto, Bruno Eymard, Katarina Pelin…

    Citation: Acta Neuropathologica Communications 2014 2:44

    Content type: Research

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  21. The self-assembly of Aβ peptides into a range of conformationally heterogeneous amyloid states represents a fundamental event in Alzheimer’s disease. Within these structures oligomeric intermediates are consid...

    Authors: Jessica Wacker, Raik Rönicke, Martin Westermann, Melanie Wulff, Klaus G Reymann, Christopher M Dobson, Uwe Horn, Damian C Crowther, Leila M Luheshi and Marcus Fändrich

    Citation: Acta Neuropathologica Communications 2014 2:43

    Content type: Research

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  22. Abnormal connectivity across brain regions underlies many neurological disorders including multiple sclerosis, schizophrenia and autism, possibly due to atypical axonal organization within white matter. Attemp...

    Authors: Xiao-Bo Liu and Cynthia M Schumann

    Citation: Acta Neuropathologica Communications 2014 2:42

    Content type: Methodology article

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  23. Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple congenital melanocytic nevi (CMN) of the skin with melanocytic lesions of the leptomeninge...

    Authors: Heidi VN Küsters-Vandevelde, Annelieke ECAB Willemsen, Patricia JTA Groenen, Benno Küsters, Martin Lammens, Pieter Wesseling, Melika Djafarihamedani, Jos Rijntjes, Hans Delye, Michel A Willemsen, Carla ML van Herpen and Willeke AM Blokx

    Citation: Acta Neuropathologica Communications 2014 2:41

    Content type: Case report

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  24. Tangle-predominant dementia (TPD) is characterized neuropathologically by numerous neurofibrillary tangles in the limbic areas with no or occasional senile plaques throughout the brain. TPD is an under-recogni...

    Authors: Ito Kawakami, Masato Hasegawa, Tetsuaki Arai, Kenji Ikeda, Kenichi Oshima, Kazuhiro Niizato, Naoya Aoki, Katsuse Omi, Shinji Higashi, Masato Hosokawa, Yoshio Hirayasu and Haruhiko Akiyama

    Citation: Acta Neuropathologica Communications 2014 2:40

    Content type: Research

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  25. Medulloblastoma (MB), the most common pediatric malignant brain cancer, typically arises as pathological result of deregulated developmental pathways, including the NOTCH signaling cascade. Unlike the evidence...

    Authors: Giulio Fiaschetti, Christina Schroeder, Deborah Castelletti, Alexandre Arcaro, Frank Westermann, Martin Baumgartner, Tarek Shalaby and Michael A Grotzer

    Citation: Acta Neuropathologica Communications 2014 2:39

    Content type: Research

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  26. Fragmentation of stacked cisterns of the Golgi apparatus into dispersed smaller elements is a feature associated with degeneration of neurons in amyotrophic lateral sclerosis (ALS) and some other neurodegenera...

    Authors: Vera van Dis, Marijn Kuijpers, Elize D Haasdijk, Eva Teuling, Scott A Oakes, Casper C Hoogenraad and Dick Jaarsma

    Citation: Acta Neuropathologica Communications 2014 2:38

    Content type: Research

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  27. Transactive response DNA binding protein 43 (TDP-43) is detected in pathological inclusions in many cases of Alzheimer’s disease (AD) and mild cognitive impairment (MCI), but its pathological role in AD and MC...

    Authors: Yasuyuki Ohta, Cyntia Tremblay, Julie A Schneider, David A Bennett, Frederic Calon and Jean-Pierre Julien

    Citation: Acta Neuropathologica Communications 2014 2:37

    Content type: Research

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  28. Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used orga...

    Authors: Sascha W Weyer, Marta Zagrebelsky, Ulrike Herrmann, Meike Hick, Lennard Ganss, Julia Gobbert, Morna Gruber, Christine Altmann, Martin Korte, Thomas Deller and Ulrike C Müller

    Citation: Acta Neuropathologica Communications 2014 2:36

    Content type: Research

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  29. Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) are present in some neuromyelitis optica patients who lack antibodies against aquaporin-4 (AQP4-IgG). The effects of neuromyelitis optica MOG-Ig...

    Authors: Samira Saadoun, Patrick Waters, Gregory P Owens, Jeffrey L Bennett, Angela Vincent and Marios C Papadopoulos

    Citation: Acta Neuropathologica Communications 2014 2:35

    Content type: Research

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  30. Intracranial aneurysm (IA) is a socially important disease due to its high incidence in the general public and the severity of resultant subarachnoid hemorrhage that follows rupture. Despite the social importa...

    Authors: Tomohiro Aoki, Miyuki Fukuda, Masaki Nishimura, Kazuhiko Nozaki and Shuh Narumiya

    Citation: Acta Neuropathologica Communications 2014 2:34

    Content type: Research

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  31. The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) refe...

    Authors: Linda K Kwong, David J Irwin, Adam K Walker, Yan Xu, Dawn M Riddle, John Q Trojanowski and Virginia M Y Lee

    Citation: Acta Neuropathologica Communications 2014 2:33

    Content type: Research

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  32. Dura mater graft-associated Creutzfeldt-Jakob disease (dCJD) can be divided into two subgroups that exhibit distinct clinical and neuropathological features, with the majority represented by a non-plaque-type ...

    Authors: Atsushi Kobayashi, Yuichi Matsuura, Shirou Mohri and Tetsuyuki Kitamoto

    Citation: Acta Neuropathologica Communications 2014 2:32

    Content type: Review

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  33. Notch and Hedgehog signaling have been implicated in the pathogenesis and stem-like characteristics of glioblastomas, and inhibitors of the pathways have been suggested as new therapies for these aggressive tu...

    Authors: Dacheng Ding, Kah Suan Lim and Charles G Eberhart

    Citation: Acta Neuropathologica Communications 2014 2:31

    Content type: Research

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  34. A major neuropathological hallmark of Alzheimer’s disease is the deposition of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β-amyloid, which is a cleavage ...

    Authors: Steffen Burgold, Severin Filser, Mario M Dorostkar, Boris Schmidt and Jochen Herms

    Citation: Acta Neuropathologica Communications 2014 2:30

    Content type: Research

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  35. The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson’s disease (PD) or dementia with Lewy b...

    Authors: Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, Damien Gaillard, Latifa Lakhdar, Ronald Melki and Thierry Baron

    Citation: Acta Neuropathologica Communications 2014 2:29

    Content type: Research

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  36. Several morphometric studies have revealed smaller than normal neurons in the neocortex of autistic subjects. To test the hypothesis that abnormal neuronal growth is a marker of an autism-associated global enc...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Ira L Cohen, Eric London, W Ted Brown and Thomas Wisniewski

    Citation: Acta Neuropathologica Communications 2014 2:28

    Content type: Research

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  37. Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the ...

    Authors: Veit Rothhammer, Andreas Muschaweckh, Georg Gasteiger, Franziska Petermann, Sylvia Heink, Dirk H Busch, Mathias Heikenwälder, Bernhard Hemmer, Ingo Drexler and Thomas Korn

    Citation: Acta Neuropathologica Communications 2014 2:27

    Content type: Research

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  38. Based on previous studies, a preclinical classification for Alzheimer’s disease (AD) has been proposed. However, 1) specificity of the different neuronal injury (NI) biomarkers has not been studied, 2) subject...

    Authors: Jon B Toledo, Michael W Weiner, David A Wolk, Xiao Da, Kewei Chen, Steven E Arnold, William Jagust, Clifford Jack, Eric M Reiman, Christos Davatzikos, Leslie M Shaw and John Q Trojanowski

    Citation: Acta Neuropathologica Communications 2014 2:26

    Content type: Research

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  39. Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but the...

    Authors: Alexandra Grubman, Grace E Lidgerwood, Clare Duncan, Laura Bica, Jiang-Li Tan, Sarah J Parker, Aphrodite Caragounis, Jodi Meyerowitz, Irene Volitakis, Diane Moujalled, Jeffrey R Liddell, James L Hickey, Malcolm Horne, Shoshanah Longmuir, Jari Koistinaho, Paul S Donnelly…

    Citation: Acta Neuropathologica Communications 2014 2:25

    Content type: Research

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  40. We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly befo...

    Authors: Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino, Henry Houlden, John Hardy and Janice L Holton

    Citation: Acta Neuropathologica Communications 2014 2:24

    Content type: Case report

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  41. Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As function...

    Authors: Diana Carvalho, Alan Mackay, Lynn Bjerke, Richard G Grundy, Celeste Lopes, Rui M Reis and Chris Jones

    Citation: Acta Neuropathologica Communications 2014 2:23

    Content type: Research

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  42. The progression of Alzheimer’s disease (AD) is associated with an increase of phosphorylated tau in the brain. One of the earliest phosphorylated sites on tau is Ser262 that is preferentially phosphorylated by mi...

    Authors: Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark and Gabriel von Euler

    Citation: Acta Neuropathologica Communications 2014 2:22

    Content type: Research

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  43. Microglial activation is a pathological feature common to both Alzheimer’s and Parkinson’s diseases (AD and PD). The classical activation involves release of pro-inflammatory cytokines and reactive oxygen spec...

    Authors: Peixuan Pey, Ronald KB Pearce, Michail E Kalaitzakis, W Sue T Griffin and Steve M Gentleman

    Citation: Acta Neuropathologica Communications 2014 2:21

    Content type: Research

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  44. Mutations in the gene for alpha-galactosidase A result in Fabry disease, a rare, X-linked lysosomal storage disorder characterized by a loss of alpha-galactosidase A enzymatic activity. The resultant accumulat...

    Authors: Michael P Nelson, Tonia E Tse, Darrel B O’Quinn, Stefanie M Percival, Edgar A Jaimes, David G Warnock and John J Shacka

    Citation: Acta Neuropathologica Communications 2014 2:20

    Content type: Research

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  45. IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in cod...

    Authors: Stefan Pusch, Leonille Schweizer, Ann-Christin Beck, Johanna-Marie Lehmler, Susanne Weissert, Jörg Balss, Aubry K Miller and Andreas von Deimling

    Citation: Acta Neuropathologica Communications 2014 2:19

    Content type: Research

    Published on:

  46. Gangliogliomas are low-grade glioneuronal tumors of the central nervous system and the commonest cause of chronic intractable epilepsy. Most gangliogliomas (>70%) arise in the temporal lobe, and infratentorial...

    Authors: Kirti Gupta, Wilda Orisme, Julie H Harreld, Ibrahim Qaddoumi, James D Dalton, Chandanamali Punchihewa, Racquel Collins-Underwood, Thomas Robertson, Ruth G Tatevossian and David W Ellison

    Citation: Acta Neuropathologica Communications 2014 2:18

    Content type: Research

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  47. The progressive development of Alzheimer’s disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the...

    Authors: Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff and Patrik Brundin

    Citation: Acta Neuropathologica Communications 2014 2:17

    Content type: Research

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  48. Axon degeneration is a characteristic feature of multiple neuropathologic states and is also a mechanism of physiological neurodevelopmental pruning. The vast majority of in vivo studies looking at axon degenerat...

    Authors: Jennifer D Sokolowski, Kanchana K Gamage, Daniel S Heffron, Andrea C LeBlanc, Christopher D Deppmann and James W Mandell

    Citation: Acta Neuropathologica Communications 2014 2:16

    Content type: Research

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  49. Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the...

    Authors: Jonathan M Bleasel, Joanna H Wong, Glenda M Halliday and Woojin Scott Kim

    Citation: Acta Neuropathologica Communications 2014 2:15

    Content type: Review

    Published on:

  50. In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration ...

    Authors: Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin and Luc Buée

    Citation: Acta Neuropathologica Communications 2014 2:14

    Content type: Research

    Published on:

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