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  1. The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies...

    Authors: L. E. M. Wisse, S. Ravikumar, R. Ittyerah, S. Lim, J. Lane, M. L. Bedard, L. Xie, S. R. Das, T. Schuck, M. Grossman, E. B. Lee, M. D. Tisdall, K. Prabhakaran, J. A. Detre, G. Mizsei, J. Q. Trojanowski…
    Citation: Acta Neuropathologica Communications 2021 9:128
  2. Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon...

    Authors: Alyssa N. Coyne and Jeffrey D. Rothstein
    Citation: Acta Neuropathologica Communications 2021 9:127
  3. Activation of the complement system propagates neuroinflammation and brain damage early and chronically after traumatic brain injury (TBI). The complement system is complex and comprises more than 50 component...

    Authors: Amer Toutonji, Mamatha Mandava, Silvia Guglietta and Stephen Tomlinson
    Citation: Acta Neuropathologica Communications 2021 9:126
  4. Peripheral nerve injury is a serious health problem and repairing long nerve deficits remains a clinical challenge nowadays. Nerve guidance conduit (NGC) serves as the most promising alternative therapy strate...

    Authors: Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen and Zan Tong
    Citation: Acta Neuropathologica Communications 2021 9:125
  5. The cellular and molecular mechanisms that drive neurodegeneration remain poorly defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of curative therapies prompted us to ...

    Authors: Pooja Jadiya, Joanne F. Garbincius and John W. Elrod
    Citation: Acta Neuropathologica Communications 2021 9:124
  6. Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and deficient levels cause spinal cord motoneurons (MNs) degeneration a...

    Authors: Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler and Ana Garcera
    Citation: Acta Neuropathologica Communications 2021 9:122
  7. Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affec...

    Authors: Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius and Hannelore Ehrenreich
    Citation: Acta Neuropathologica Communications 2021 9:121
  8. Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) neoplasm in adults, and has an almost universally poor prognosis. Recently, an emphasis on genetic and epigenetic profiling ...

    Authors: James F. Lyon, Varshini Vasudevaraja, Kanish Mirchia, Jamie M. Walker, Robert J. Corona, Lawrence S. Chin, Ivy Tran, Matija Snuderl, Timothy E. Richardson and Mariano S. Viapiano
    Citation: Acta Neuropathologica Communications 2021 9:120
  9. Primary spinal cord astrocytomas are rare, hence few data exist about the prognostic significance of molecular markers. Here we analyze a panel of molecular alterations in association with the clinical course....

    Authors: Annamaria Biczok, Felix L. Strübing, Julia M. Eder, Rupert Egensperger, Oliver Schnell, Stefan Zausinger, Julia E. Neumann, Jochen Herms, Joerg-Christian Tonn and Mario M. Dorostkar
    Citation: Acta Neuropathologica Communications 2021 9:119
  10. Traumatic brain injury (TBI) constitutes one of the strongest environmental risk factors for several progressive neurodegenerative disorders of cognitive impairment and dementia that are characterized by the p...

    Authors: Aydan Kahriman, James Bouley, Thomas W. Smith, Daryl A. Bosco, Amanda L. Woerman and Nils Henninger
    Citation: Acta Neuropathologica Communications 2021 9:118
  11. Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneles...

    Authors: Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene and Brian C. Kraemer
    Citation: Acta Neuropathologica Communications 2021 9:117
  12. Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic m...

    Authors: Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan and Marianne Schultzberg
    Citation: Acta Neuropathologica Communications 2021 9:116
  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera and Akiyoshi Kakita
    Citation: Acta Neuropathologica Communications 2021 9:115

    The original article was published in Acta Neuropathologica Communications 2021 9:106

  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller and Noah E. Berlow
    Citation: Acta Neuropathologica Communications 2021 9:114

    The original article was published in Acta Neuropathologica Communications 2021 9:88

  15. Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in...

    Authors: Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum and Yijuang Chern
    Citation: Acta Neuropathologica Communications 2021 9:112
  16. The deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that caus...

    Authors: Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund and Ulrika Nordström
    Citation: Acta Neuropathologica Communications 2021 9:111
  17. The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis...

    Authors: Harrison Tudor Evans, Deonne Taylor, Andrew Kneynsberg, Liviu-Gabriel Bodea and Jürgen Götz
    Citation: Acta Neuropathologica Communications 2021 9:110
  18. Hypokalemic periodic paralysis is an autosomal dominant, rare disorder caused by variants in the genes for voltage-gated calcium channel CaV1.1 (CACNA1S) and NaV1.4 (SCN4A). Patients with hypokalemic periodic par...

    Authors: Thomas O. Krag, Sonja Holm-Yildiz, Nanna Witting and John Vissing
    Citation: Acta Neuropathologica Communications 2021 9:109
  19. Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered k...

    Authors: Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi and Ilse Dewachter
    Citation: Acta Neuropathologica Communications 2021 9:108
  20. Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopam...

    Authors: Min Lin, Phillip M. Mackie, Fatima Shaerzadeh, Joyonna Gamble-George, Douglas R. Miller, Chris J. Martyniuk and Habibeh Khoshbouei
    Citation: Acta Neuropathologica Communications 2021 9:107
  21. Authors: Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera and Akiyoshi Kakita
    Citation: Acta Neuropathologica Communications 2021 9:106

    The Correction to this article has been published in Acta Neuropathologica Communications 2021 9:115

  22. Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several fi...

    Authors: Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen and Asad Jan
    Citation: Acta Neuropathologica Communications 2021 9:105
  23. The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after exclusion of neural tube defects. Classification criteria are bas...

    Authors: Florent Marguet, Myriam Vezain, Pascale Marcorelles, Séverine Audebert-Bellanger, Kévin Cassinari, Nathalie Drouot, Pascal Chambon, Bruno J. Gonzalez, Arie Horowitz, Annie Laquerriere and Pascale Saugier-Veber
    Citation: Acta Neuropathologica Communications 2021 9:104
  24. The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microgl...

    Authors: Parand Zarekiani, Marjolein Breur, Nicole I. Wolf, Helga E. de Vries, Marjo S. van der Knaap and Marianna Bugiani
    Citation: Acta Neuropathologica Communications 2021 9:103
  25. Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high prevalence rate among the elderly population. A large number of clinical studies have suggested repetitive transcranial magnetic st...

    Authors: Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye and Wei-Jye Lin
    Citation: Acta Neuropathologica Communications 2021 9:102
  26. Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors...

    Authors: Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown and Christopher G. Hubert
    Citation: Acta Neuropathologica Communications 2021 9:101
  27. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto and Koichi Ichimura
    Citation: Acta Neuropathologica Communications 2021 9:100

    The original article was published in Acta Neuropathologica Communications 2021 9:36

  28. Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homog...

    Authors: Brian D. Hitt, Jaime Vaquer-Alicea, Victor A. Manon, Joshua D. Beaver, Omar M. Kashmer, Jan N. Garcia and Marc I. Diamond
    Citation: Acta Neuropathologica Communications 2021 9:99
  29. Short tandem repeat (STR) expansion disorders are an important cause of human neurological disease. They have an established role in more than 40 different phenotypes including the myotonic dystrophies, Fragil...

    Authors: Sanjog R. Chintalaphani, Sandy S. Pineda, Ira W. Deveson and Kishore R. Kumar
    Citation: Acta Neuropathologica Communications 2021 9:98
  30. Zika virus (ZIKV), a mosquito-borne flavivirus, can cause severe eye disease and even blindness in newborns. However, ZIKV-induced retinal lesions have not been studied in a comprehensive way, mechanisms of ZI...

    Authors: Yi Li, Shuizhen Shi, Fan Xia, Chao Shan, Yonju Ha, Jing Zou, Awadalkareem Adam, Ming Zhang, Tian Wang, Hua Liu, Pei-Yong Shi and Wenbo Zhang
    Citation: Acta Neuropathologica Communications 2021 9:97
  31. Oligodendrogliomas are defined by mutation in isocitrate dehydrogenase (NADP(+)) (IDH)1/2 genes and chromosome 1p/19q codeletion. World Health Organisation diagnosis endorses testing for 1p/19q codeletion to dist...

    Authors: Umma Habiba, Hirokazu Sugino, Roumyana Yordanova, Koki Ise, Zen-ichi Tanei, Yusuke Ishida, Satoshi Tanikawa, Shunsuke Terasaka, Ken-ichi Sato, Yuuta Kamoshima, Masahiko Katoh, Motoo Nagane, Junji Shibahara, Masumi Tsuda and Shinya Tanaka
    Citation: Acta Neuropathologica Communications 2021 9:95
  32. Fluorescent staining of newly transcribed RNA via metabolic labelling with 5-ethynyluridine (EU) and click chemistry enables visualisation of changes in transcription, such as in conditions of cellular stress....

    Authors: Lisanne J. van’t Sant, Joshua J. White, Jan H. J. Hoeijmakers, Wilbert P. Vermeij and Dick Jaarsma
    Citation: Acta Neuropathologica Communications 2021 9:94
  33. Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male sex have previously been reported...

    Authors: Joseph S. Reddy, Mariet Allen, Charlotte C. G. Ho, Stephanie R. Oatman, Özkan İş, Zachary S. Quicksall, Xue Wang, Jiangli Jin, Tulsi A. Patel, Troy P. Carnwath, Thuy T. Nguyen, Kimberly G. Malphrus, Sarah J. Lincoln, Minerva M. Carrasquillo, Julia E. Crook, Takahisa Kanekiyo…
    Citation: Acta Neuropathologica Communications 2021 9:93
  34. Misfolded forms of superoxide dismutase 1 (SOD1) with mutations associated with familial amyotrophic lateral sclerosis (fALS) exhibit prion characteristics, including the ability to act as seeds to accelerate ...

    Authors: Jacob I. Ayers, Guilian Xu, Kristy Dillon, Qing Lu, Zhijuan Chen, John Beckman, Alma K. Moreno-Romero, Diana L. Zamora, Ahmad Galaleldeen and David R. Borchelt
    Citation: Acta Neuropathologica Communications 2021 9:92
  35. V-type immunoglobulin domain-containing suppressor of T-cell activation (VISTA) is a negative checkpoint regulator (NCR) that is involved in T-cell quiescence, inhibition of T-cell activation, and in myeloid c...

    Authors: Malte Borggrewe, Susanne M. Kooistra, Evelyn M. Wesseling, Fenja L. Gierschek, Maaike L. Brummer, Elizabeth C. Nowak, Tiago Medeiros-Furquim, Tegan A. Otto, Sam W. Lee, Randolph J. Noelle, Bart J. L. Eggen and Jon D. Laman
    Citation: Acta Neuropathologica Communications 2021 9:91
  36. Tauopathies are a group of neurodegenerative diseases characterized by the alteration/aggregation of TAU protein, for which there is still no effective treatment. Therefore, new pharmacological targets are bei...

    Authors: M. Galán-Ganga, C. Rodríguez-Cueto, J. Merchán-Rubira, F. Hernández, J. Ávila, M. Posada-Ayala, J. L. Lanciego, E. Luengo, M. G. Lopez, A. Rábano, J. Fernández-Ruiz and I. Lastres-Becker
    Citation: Acta Neuropathologica Communications 2021 9:90
  37. Traumatic brain injury (TBI) causes chronic symptoms and increased risk of neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are critical components of neural circuits and part...

    Authors: Donald V. Bradshaw Jr., Andrew K. Knutsen, Alexandru Korotcov, Genevieve M. Sullivan, Kryslaine L. Radomski, Bernard J. Dardzinski, Xiaomei Zi, Dennis P. McDaniel and Regina C. Armstrong
    Citation: Acta Neuropathologica Communications 2021 9:89
  38. Diffuse intrinsic pontine glioma (DIPG), a rare pediatric brain tumor, afflicts approximately 350 new patients each year in the United States. DIPG is noted for its lethality, as fewer than 1% of patients surv...

    Authors: Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller and Noah E. Berlow
    Citation: Acta Neuropathologica Communications 2021 9:88

    The Correction to this article has been published in Acta Neuropathologica Communications 2021 9:114

  39. In neurodegenerative diseases including Alzheimer’s, Parkinson’s and prion diseases, astrocytes acquire disease-associated reactive phenotypes. With growing appreciation of their role in chronic neurodegenerat...

    Authors: Natallia Makarava, Olga Mychko, Jennifer Chen-Yu Chang, Kara Molesworth and Ilia V. Baskakov
    Citation: Acta Neuropathologica Communications 2021 9:87
  40. Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease, characterized by hyperphosphorylated tau, found in individuals with a history of exposure to repetitive head impacts. While th...

    Authors: Jonathan D. Cherry, Camille D. Esnault, Zachary H. Baucom, Yorghos Tripodis, Bertrand R. Huber, Victor E. Alvarez, Thor D. Stein, Dennis W. Dickson and Ann C. McKee
    Citation: Acta Neuropathologica Communications 2021 9:86
  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad and Laura J. Blair
    Citation: Acta Neuropathologica Communications 2021 9:85

    The original article was published in Acta Neuropathologica Communications 2021 9:65

  42. Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular...

    Authors: Xiao Zhang, Paul O’Callaghan, Honglian Li, Yingxia Tan, Ganlin Zhang, Uri Barash, Xiaomin Wang, Lars Lannfelt, Israel Vlodavsky, Ulf Lindahl and Jin-Ping Li
    Citation: Acta Neuropathologica Communications 2021 9:84
  43. When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-...

    Authors: Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms and Joel C. Watts
    Citation: Acta Neuropathologica Communications 2021 9:83
  44. Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated L...

    Authors: Kevin Peikert, Enrica Federti, Alessandro Matte, Gabriela Constantin, Enrica Caterina Pietronigro, Paolo Francesco Fabene, Paola Defilippi, Emilia Turco, Federico Del Gallo, Pietro Pucci, Angela Amoresano, Anna Illiano, Flora Cozzolino, Maria Monti, Francesca Garello, Enzo Terreno…
    Citation: Acta Neuropathologica Communications 2021 9:81
  45. Multiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of MSA i...

    Authors: Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop and Benoit I. Giasson
    Citation: Acta Neuropathologica Communications 2021 9:80
  46. The MYH2 gene encodes the skeletal muscle myosin heavy chain IIA (MyHC-IIA) isoform, which is expressed in the fast twitch type 2A fibers. Autosomal dominant or recessive pathogenic variants in MYH2 lead to conge...

    Authors: Nicolas N. Madigan, Michael J. Polzin, Gaofeng Cui, Teerin Liewluck, Mohammad H. Alsharabati, Christopher J. Klein, Anthony J. Windebank, Georges Mer and Margherita Milone
    Citation: Acta Neuropathologica Communications 2021 9:79

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