Articles

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

Seeding and spread of beta-amyloid (Aβ) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of Aβ seeding activity upon peripheral exposure would represent ...

Authors: Michael Burwinkel, Manuel Lutzenberger, Frank L. Heppner, Walter Schulz-Schaeffer and Michael Baier

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes

Alzheimer’s disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles. However, over the past se...

Authors: Sara E. Nasrabady, Batool Rizvi, James E. Goldman and Adam M. Brickman

Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry

All isocitrate dehydrogenase (IDH) mutant solid neoplasms exhibit highly elevated levels of D-2-hydroxyglutarate (D-2HG). Detection of 2HG in tumor tissues currently is performed by gas or liquid chromatograph...

Authors: Rémi Longuespée, Annika K. Wefers, Elena De Vita, Aubry K. Miller, David E. Reuss, Wolfgang Wick, Christel Herold-Mende, Mark Kriegsmann, Peter Schirmacher, Andreas von Deimling and Stefan Pusch

Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients

Synaptic dysfunction or loss in early stages of Alzheimer’s disease (AD) is thought to be a major structural correlate of cognitive dysfunction. Early loss of episodic memory, which occurs at the early stage o...

Authors: M. Domínguez-Álvaro, M. Montero-Crespo, L. Blazquez-Llorca, R. Insausti, J. DeFelipe and L. Alonso-Nanclares

Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease

Although the genetic causes for several rare, familial forms of Alzheimer’s disease (AD) have been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a systems-level study of ...

Authors: Qi Zhang, Cheng Ma, Marla Gearing, Peng George Wang, Lih-Shen Chin and Lian Li

CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival

Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of adaptive and innate anti-tumor response including the Hum...

Authors: P. S. Zeiner, J. Zinke, D. J. Kowalewski, S. Bernatz, J. Tichy, M. W. Ronellenfitsch, F. Thorsen, A. Berger, M. T. Forster, A. Muller, J. P. Steinbach, R. Beschorner, J. Wischhusen, H. M. Kvasnicka, K. H. Plate, S. Stefanović…

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Traumatic brain injury (TBI) induces a wide variety of cellular and molecular changes that can continue for days to weeks to months, leading to functional impairments. Currently, there are no pharmacotherapies...

Authors: Anssi Lipponen, Assam El-Osta, Antony Kaspi, Mark Ziemann, Ishant Khurana, Harikrishnan KN, Vicente Navarro-Ferrandis, Noora Puhakka, Jussi Paananen and Asla Pitkänen

Clinical significance of polyglutamylation in primary central nervous system lymphoma

The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rat...

Authors: Naoki Shinojima, Kenji Fujimoto, Keishi Makino, Kohei Todaka, Kazumichi Yamada, Yoshiki Mikami, Kazutaka Oda, Kazumi Nakamura, Hirofumi Jono, Jun-ichi Kuratsu, Hideo Nakamura, Shigetoshi Yano and Akitake Mukasa

Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin

Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further charact...

Authors: Grazyna Lietzau, William Davidsson, Claes-Göran Östenson, Fausto Chiazza, David Nathanson, Hiranya Pintana, Josefin Skogsberg, Thomas Klein, Thomas Nyström, Vladimer Darsalia and Cesare Patrone

Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein

Human familial prion diseases are associated with mutations at 34 different prion protein (PrP) amino acid residues. However, it is unclear whether infectious prions are found in all cases. Mutant PrP itself m...

Authors: Brent Race, Katie Williams, Andrew G. Hughson, Casper Jansen, Piero Parchi, Annemieke J. M. Rozemuller and Bruce Chesebro

Cooperative p16 and p21 action protects female astrocytes from transformation

Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism ...

Authors: Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell, Kelsey L. Tinkum, Zongtai Qi, Nicole M. Warrington, Peter McDonald, Anuradha Roy, Scott J. Weir, Carrie A. Mohila, Benjamin Deneen and Joshua B. Rubin

Diffuse microvascular C5b-9 deposition is a common feature in muscle and nerve biopsies from diabetic patients

Terminal complement complex deposition in endomysial capillaries detected by a C5b-9 immunostain is considered a diagnostic feature for dermatomyositis. However, we found widespread microvascular C5b-9 reactiv...

Authors: Paul C. Yell, Dennis K. Burns, Evan G. Dittmar, Charles L. White III and Chunyu Cai

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neu...

Authors: Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan and Jürgen Götz

Brain region-specific enhancement of remyelination and prevention of demyelination by the CSF1R kinase inhibitor BLZ945

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CN...

Authors: Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff and Derya R. Shimshek

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC

The diagnosis and treatment of synucleinopathies such as Parkinson disease and dementia with Lewy bodies would be aided by the availability of assays for the pathogenic disease-associated forms of α-synuclein ...

Authors: Bradley R. Groveman, Christina D. Orrù, Andrew G. Hughson, Lynne D. Raymond, Gianluigi Zanusso, Bernardino Ghetti, Katrina J. Campbell, Jiri Safar, Douglas Galasko and Byron Caughey

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients

In Parkinson’s disease (PD) there is widespread accumulation in the brain of abnormal α-synuclein aggregates forming intraneuronal Lewy bodies (LB). It is now well established that LB-type α-synuclein aggregat...

Authors: Ariadna Recasens, Iria Carballo-Carbajal, Annabelle Parent, Jordi Bové, Ellen Gelpi, Eduardo Tolosa and Miquel Vila

Exceptional in vivo catabolism of neurodegeneration-related aggregates

Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a unique phenomenon that Philodina acuticornis, a bdell...

Authors: Zsolt Datki, Zita Olah, Tibor Hortobagyi, Lilla Macsai, Katalin Zsuga, Livia Fulop, Zsolt Bozso, Bence Galik, Eva Acs, Angela Foldi, Amanda Szarvas and Janos Kalman

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from h...

Authors: Ignazio Cali, Mark L. Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J. Collins, Diane Kofskey, Han Wang, Catriona A. McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D. Belay, Ryan A. Maddox…

Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate p...

Authors: Jordan R. Warford, Anna-Claire Lamport, Derek R. Clements, Alicia Malone, Barry E. Kennedy, Youra Kim, Shashi A. Gujar, David W. Hoskin and Alexander S. Easton

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developi...

Authors: Maria Luisa Moro, Andrew Stephen Phillips, Katie Gaimster, Christian Paul, Amritpal Mudher, James A. R. Nicoll and Delphine Boche

Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder characterized by widespread oligodendroglial cytoplasmic inclusions of filamentous α-synuclein, and neuronal loss in autonomic ...

Authors: Violetta Refolo, Francesco Bez, Alexia Polissidis, Daniela Kuzdas-Wood, Edith Sturm, Martina Kamaratou, Werner Poewe, Leonidas Stefanis, M. Angela Cenci, Marina Romero-Ramos, Gregor K. Wenning and Nadia Stefanova

Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β

Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the prop...

Authors: Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi and Toshiki Uchihara

What is the evidence that tau pathology spreads through prion-like propagation?

Emerging experimental evidence suggests that the spread of tau pathology in the brain in Tauopathies reflects the propagation of abnormal tau species along neuroanatomically connected brain areas. This propaga...

Authors: Amrit Mudher, Morvane Colin, Simon Dujardin, Miguel Medina, Ilse Dewachter, Seyedeh Maryam Alavi Naini, Eva-Maria Mandelkow, Eckhard Mandelkow, Luc Buée, Michel Goedert and Jean-Pierre Brion

Absence of MGMT promoter methylation in diffuse midline glioma, H3 K27M-mutant

Authors: Rouzbeh Banan, Arne Christians, Stephan Bartels, Ulrich Lehmann and Christian Hartmann

Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype

The authors are retracting this article. The article describes mice expressing wild-type human MATR3. However, since publication the authors have become aware that all of the lines of mice described express hu...

Authors: Christina Moloney, Sruti Rayaprolu, John Howard, Susan Fromholt, Hilda Brown, Matt Collins, Mariela Cabrera, Colin Duffy, Zoe Siemienski, Dave Miller, Maurice S. Swanson, Lucia Notterpek, David R. Borchelt and Jada Lewis

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

Mutations in the stress granule protein T-cell restricted intracellular antigen 1 (TIA1) were recently shown to cause amyotrophic lateral sclerosis (ALS) with or without frontotemporal dementia (FTD). Here, we...

Authors: Veronica Hirsch-Reinshagen, Cyril Pottier, Alexandra M. Nicholson, Matt Baker, Ging-Yuek R. Hsiung, Charles Krieger, Pheth Sengdy, Kevin B. Boylan, Dennis W. Dickson, Marsel Mesulam, Sandra Weintraub, Eileen Bigio, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Sasha A. Zivkovic…

Metabolomics reveals distinct, antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease

The overlapping clinical features of relapsing remitting multiple sclerosis (RRMS), aquaporin-4 (AQP4)-antibody (Ab) neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG...

Authors: Maciej Jurynczyk, Fay Probert, Tianrong Yeo, George Tackley, Tim D. W. Claridge, Ana Cavey, Mark R. Woodhall, Siddharth Arora, Torsten Winkler, Eric Schiffer, Angela Vincent, Gabriele DeLuca, Nicola R. Sibson, M. Isabel Leite, Patrick Waters, Daniel C. Anthony…

Blood-brain barrier hyperpermeability precedes demyelination in the cuprizone model

In neuroinflammatory disorders such as multiple sclerosis, the physiological function of the blood-brain barrier (BBB) is perturbed, particularly in demyelinating lesions and supposedly secondary to acute demy...

Authors: Stefan A. Berghoff, Tim Düking, Lena Spieth, Jan Winchenbach, Sina K. Stumpf, Nina Gerndt, Kathrin Kusch, Torben Ruhwedel, Wiebke Möbius and Gesine Saher

Cerebrovascular pathology in Down syndrome and Alzheimer disease

People with Down syndrome (DS) are at high risk for developing Alzheimer disease (AD) with age. Typically, by age 40 years, most people with DS have sufficient neuropathology for an AD diagnosis. Interestingly...

Authors: Elizabeth Head, Michael J. Phelan, Eric Doran, Ronald C. Kim, Wayne W. Poon, Frederick A. Schmitt and Ira T. Lott

MUNC18–1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development

While Munc18–1 interacts with Syntaxin1 and controls the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE) complex to regulate presynaptic vesicle fusion in developed ...

Authors: Nanako Hamada, Ikuko Iwamoto, Hidenori Tabata and Koh-ichi Nagata

Atypical, non-standard functions of the microtubule associated Tau protein

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological cons...

Authors: Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher and Luc Buee

EuroTau: towing scientists to tau without tautology

Authors: Amrit Mudher, Jean-Pierre Brion, Jesus Avila, Miguel Medina and Luc Buée

Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions

Microtubule-associated protein tau aggregates constitute the characteristic neuropathological features of several neurodegenerative diseases grouped under the name of tauopathies. It is now clear that the proc...

Authors: Marta Sidoryk-Wegrzynowicz, Yannick N. Gerber, Miriam Ries, Magdalena Sastre, Aviva M. Tolkovsky and Maria Grazia Spillantini

The chronically inflamed central nervous system provides niches for long-lived plasma cells

Although oligoclonal bands in the cerebrospinal fluid have been a hallmark of multiple sclerosis diagnosis for over three decades, the role of antibody-secreting cells in multiple sclerosis remains unclear. T ...

Authors: Karolin Pollok, Ronja Mothes, Carolin Ulbricht, Alina Liebheit, Jan David Gerken, Sylvia Uhlmann, Friedemann Paul, Raluca Niesner, Helena Radbruch and Anja Erika Hauser

Atypical Creutzfeldt-Jakob disease with PrP-amyloid plaques in white matter: molecular characterization and transmission to bank voles show the M1 strain signature

Amyloid plaques formed by abnormal prion protein (PrP^Sc) aggregates occur with low frequency in Creutzfeldt-Jakob disease, but represent a pathological hallmark of three relatively rare disease histotypes, namely...

Authors: Marcello Rossi, Daniela Saverioni, Michele Di Bari, Simone Baiardi, Afina Willemina Lemstra, Laura Pirisinu, Sabina Capellari, Annemieke Rozemuller, Romolo Nonno and Piero Parchi

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 mutations increase LRRK2 kinase activities that may increase levels of LRRK2 autophosphorylat...

Authors: Shijie Wang, Zhiyong Liu, Tao Ye, Omar S. Mabrouk, Tyler Maltbie, Jan Aasly and Andrew B. West

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

Genetic variation in a major histocompatibility complex II (MHCII)-encoding gene (HLA-DR) increases risk for Parkinson disease (PD), and the accumulation of MHCII-expressing immune cells in the brain correlates w...

Authors: Ashley S. Harms, Vedad Delic, Aaron D. Thome, Nicole Bryant, Zhiyong Liu, Sidhanth Chandra, Asta Jurkuvenaite and Andrew B. West

A novel vector for transgenesis in the rat CNS

The larger brain of the rat enables a much greater repertoire of complex behaviors than mice, likely making rats preferential for investigating neurodegeneration. Because molecular tools for specific expressio...

Authors: T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson and Stanley B. Prusiner

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders

Endothelin-converting enzyme-like 1 (ECEL1, also termed DINE in rodents), a membrane-bound metalloprotease, has been identified as a gene responsible for distal arthrogryposis (DA). ECEL1-mutated DA is generally ...

Authors: Kenichi Nagata, Mika Takahashi, Sumiko Kiryu-Seo, Hiroshi Kiyama and Takaomi C. Saido

Lack of chronic neuroinflammation in the absence of focal hemorrhage in a rat model of low-energy blast-induced TBI

Blast-related traumatic brain injury (TBI) has been a common cause of injury in the recent conflicts in Iraq and Afghanistan. Blast waves can damage blood vessels, neurons, and glial cells within the brain. Ac...

Authors: Miguel A. Gama Sosa, Rita De Gasperi, Georgina S. Perez Garcia, Heidi Sosa, Courtney Searcy, Danielle Vargas, Pierce L. Janssen, Gissel M. Perez, Anna E. Tschiffely, William G. Janssen, Richard M. McCarron, Patrick R. Hof, Fatemeh G. Haghighi, Stephen T. Ahlers and Gregory A. Elder

Deposition of mutant ubiquitin in parkinsonism–dementia complex of Guam

Authors: Bert M. Verheijen, Tomoyo Hashimoto, Kiyomitsu Oyanagi and Fred W. van Leeuwen

Clusterin protects neurons against intracellular proteotoxicity

It is now widely accepted in the field that the normally secreted chaperone clusterin is redirected to the cytosol during endoplasmic reticulum (ER) stress, although the physiological function(s) of this physi...

Authors: Jenna M. Gregory, Daniel R. Whiten, Rebecca A. Brown, Teresa P. Barros, Janet R. Kumita, Justin J. Yerbury, Sandeep Satapathy, Karina McDade, Colin Smith, Leila M. Luheshi, Christopher M. Dobson and Mark R. Wilson

Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons

Hypersynchronous neuronal excitation manifests clinically as seizure (ictogenesis), and may recur spontaneously and repetitively after a variable latency period (epileptogenesis). Despite tremendous research e...

Authors: K. Kiese, J. Jablonski, J. Hackenbracht, J. K. Wrosch, T. W. Groemer, J. Kornhuber, I. Blümcke and K. Kobow

Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas

Pediatric high-grade gliomas (pHGGs) are aggressive neoplasms representing approximately 20% of brain tumors in children. Current therapies offer limited disease control, and patients have a poor prognosis. Em...

Authors: Ralph Salloum, Melissa K. McConechy, Leonie G. Mikael, Christine Fuller, Rachid Drissi, Mariko DeWire, Hamid Nikbakht, Nicolas De Jay, Xiaodan Yang, Daniel Boue, Lionel M. L. Chow, Jonathan L. Finlay, Tenzin Gayden, Jason Karamchandani, Trent R. Hummel, Randal Olshefski…

CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer’s PSEN2 ^N141I neurons

Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory form...

Authors: Maitane Ortiz-Virumbrales, Cesar L. Moreno, Ilya Kruglikov, Paula Marazuela, Andrew Sproul, Samson Jacob, Matthew Zimmer, Daniel Paull, Bin Zhang, Eric E. Schadt, Michelle E. Ehrlich, Rudolph E. Tanzi, Ottavio Arancio, Scott Noggle and Sam Gandy

Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis

The identification of the TAR DNA-binding protein 43 (TDP-43) as the ubiquitinated cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) confirmed that thes...

Authors: Rachel H. Tan, Yue Yang, Woojin S. Kim, Carol Dobson-Stone, John B. Kwok, Matthew C. Kiernan and Glenda M. Halliday

Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson’s case

[F-18]-AV-1451 is a novel positron emission tomography (PET) tracer with high affinity to neurofibrillary tau pathology in Alzheimer’s disease (AD). PET studies have shown increased tracer retention in patient...

Authors: Marta Marquié, Eline E. Verwer, Avery C. Meltzer, Sally Ji Who Kim, Cinthya Agüero, Jose Gonzalez, Sara J. Makaretz, Michael Siao Tick Chong, Prianca Ramanan, Ana C. Amaral, Marc D. Normandin, Charles R. Vanderburg, Stephen N. Gomperts, Keith A. Johnson, Matthew P. Frosch and Teresa Gómez-Isla

Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons

The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are a group of inherited, fatal neurodegenerative disorders of childhood. In these disorders, glial (microglial and astrocyte) activation typically o...

Authors: Lotta Parviainen, Sybille Dihanich, Greg W. Anderson, Andrew M. Wong, Helen R. Brooks, Rosella Abeti, Payam Rezaie, Giovanna Lalli, Simon Pope, Simon J. Heales, Hannah M. Mitchison, Brenda P. Williams and Jonathan D. Cooper

Distinct deposition of amyloid-β species in brains with Alzheimer’s disease pathology visualized with MALDI imaging mass spectrometry

Amyloid β (Aβ) deposition in the brain is an early and invariable feature of Alzheimer’s disease (AD). The Aβ peptides are composed of about 40 amino acids and are generated from amyloid precursor proteins (AP...

Authors: Nobuto Kakuda, Tomohiro Miyasaka, Noriyuki Iwasaki, Takashi Nirasawa, Satoko Wada-Kakuda, Junko Takahashi-Fujigasaki, Shigeo Murayama, Yasuo Ihara and Masaya Ikegawa

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this ...

Authors: Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O. Fürst, Matthias Vorgerd and Wolfgang A. Linke