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  1. Content type: Research

    Parkinson’s disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism for this α-synucleinopathy. Early neuropathologica...

    Authors: Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Alicia Mohedano-Moriano, Alino Martinez-Marcos and Isabel Ubeda-Bañon

    Citation: Acta Neuropathologica Communications 2019 7:56

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  2. Content type: Research

    Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetrat...

    Authors: Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Nymark Aasen, Gro Vatne Røsland, Jobin K. Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick N. Harter, Kai Ove Skaftnesmo, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Clifford G. Tepper, Kjell Petersen…

    Citation: Acta Neuropathologica Communications 2019 7:55

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  3. Content type: Research

    Recently, moderate prenatal alcohol exposure (PAE) was shown to be a risk factor for peripheral neuropathy following minor nerve injury. This effect coincides with elevated spinal cord astrocyte activation and...

    Authors: Joshua J. Sanchez, Jacob E. Sanchez, Shahani Noor, Chaselyn D. Ruffaner-Hanson, Suzy Davies, Carston R. Wagner, Lauren L. Jantzie, Nikolaos Mellios, Daniel D. Savage and Erin D. Milligan

    Citation: Acta Neuropathologica Communications 2019 7:54

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  4. Content type: Research

    Current evidence indicating a role of the human prion protein (PrP) in amyloid-beta (Aβ) formation or a synergistic effect between Aβ and prion pathology remains controversial. Conflicting results also concern...

    Authors: Marcello Rossi, Hideaki Kai, Simone Baiardi, Anna Bartoletti-Stella, Benedetta Carlà, Corrado Zenesini, Sabina Capellari, Tetsuyuki Kitamoto and Piero Parchi

    Citation: Acta Neuropathologica Communications 2019 7:53

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  5. Content type: Research

    Genome-wide expression profiling studies have identified four core molecular subgroups of medulloblastoma: WNT, SHH, Group 3 and Group 4. Molecular markers are necessary for accurate risk stratification in the...

    Authors: Harish Shrikrishna Bharambe, Raikamal Paul, Pooja Panwalkar, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, Sadaf Kazi, Akash Deogharkar, Shalaka Masurkar, Kedar Yogi, Ratika Kunder, Nikhil Gadewal, Atul Goel, Naina Goel…

    Citation: Acta Neuropathologica Communications 2019 7:52

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  6. Content type: Research

    Brain water homeostasis is essential for the appropriate control of neuronal activity. Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the ...

    Authors: Claudia Palazzo, Cinzia Buccoliero, Maria Grazia Mola, Pasqua Abbrescia, Grazia Paola Nicchia, Maria Trojano and Antonio Frigeri

    Citation: Acta Neuropathologica Communications 2019 7:51

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  7. Content type: Research

    TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral s...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang and C.-K. James Shen

    Citation: Acta Neuropathologica Communications 2019 7:50

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  8. Content type: Research

    A previous study reported that a massive cerebral infarct in the territory of the middle cerebral artery (MCA) may be associated with development of neurofibrillary tangles (NFTs) in the ipsilateral basal nucl...

    Authors: Hiroyuki Hatsuta, Masaki Takao, Akane Nogami, Akiko Uchino, Hiroyuki Sumikura, Tadayuki Takata, Satoru Morimoto, Kazutomi Kanemaru, Tadashi Adachi, Tomio Arai, Masato Hasegawa and Shigeo Murayama

    Citation: Acta Neuropathologica Communications 2019 7:49

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  9. Content type: Research

    Degeneration of photoreceptors in the retina is a major cause of blindness in humans. Often retinal degeneration is due to inheritance of mutations in genes important in photoreceptor (PR) function, but can al...

    Authors: James F. Striebel, Brent Race, Katie Williams, James A. Carroll, Mikael Klingeborn and Bruce Chesebro

    Citation: Acta Neuropathologica Communications 2019 7:48

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  10. Content type: Research

    Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer’s disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in...

    Authors: Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau…

    Citation: Acta Neuropathologica Communications 2019 7:46

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  11. Content type: Research

    Over the past two decades a number of studies have demonstrated activity of the retroviral enzyme reverse transcriptase in the serum of patients with sporadic amyotrophic lateral sclerosis (ALS). Known human exog...

    Authors: Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day and Adele L. McCormick

    Citation: Acta Neuropathologica Communications 2019 7:45

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    The Letter to the Editor to this article has been published in Acta Neuropathologica Communications 2019 7:101

  12. Content type: Research

    A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, ...

    Authors: Jennifer A. Macdonald, Iraad F. Bronner, Lesley Drynan, Juan Fan, Annabelle Curry, Graham Fraser, Isabelle Lavenir and Michel Goedert

    Citation: Acta Neuropathologica Communications 2019 7:44

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  13. Content type: Research

    Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We a...

    Authors: Norman L. Lehman, Aisulu Usubalieva, Tong Lin, Sariah J. Allen, Quynh T. Tran, Bret C. Mobley, Roger E. McLendon, Matthew J. Schniederjan, Maria-Magdalena Georgescu, Marta Couce, Mohanpal S. Dulai, Jack M. Raisanen, Mousa Al Abbadi, Cheryl A. Palmer, Eyas M. Hattab and Brent A. Orr

    Citation: Acta Neuropathologica Communications 2019 7:42

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  14. Content type: Research

    Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but t...

    Authors: Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore and Jiyan Ma

    Citation: Acta Neuropathologica Communications 2019 7:41

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  15. Content type: Research

    Autism is a neurodevelopmental connectivity disorder characterized by cortical network disorganization and imbalance in excitation/inhibition. However, little is known about the development of autism pathology...

    Authors: Iris Margalit Trutzer, Miguel Ángel García-Cabezas and Basilis Zikopoulos

    Citation: Acta Neuropathologica Communications 2019 7:40

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  16. Content type: Research

    Human homologue of yeast UV excision repair protein Rad23b (HR23B) inclusions are found in a number of neurodegenerative diseases, including frontotemporal dementia (FTD), Huntington’s disease (HD), spinocereb...

    Authors: Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten and Rob Willemsen

    Citation: Acta Neuropathologica Communications 2019 7:39

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  17. Content type: Research

    Encephalitis with anti-NMDAR antibodies (NMDAR-E) is a severe autoimmune neurological disorder, defined by a clinical presentation of encephalitis and the presence of IgG targeting the GluN1 subunit of NMDA re...

    Authors: Aude Chefdeville, Isabelle Treilleux, Marie-Eve Mayeur, Coline Couillault, Géraldine Picard, Chloé Bost, Karima Mokhtari, Alexandre Vasiljevic, David Meyronet, Véronique Rogemond, Dimitri Psimaras, Bertrand Dubois, Jérôme Honnorat and Virginie Desestret

    Citation: Acta Neuropathologica Communications 2019 7:38

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  18. Content type: Research

    [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection...

    Authors: Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch and Teresa Gomez-Isla

    Citation: Acta Neuropathologica Communications 2019 7:37

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  19. Content type: Research

    Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform...

    Authors: Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson and Leonard Petrucelli

    Citation: Acta Neuropathologica Communications 2019 7:36

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  20. Content type: Research

    Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions. This signaling involves close physical contacts between the two organelles that are mediated by “...

    Authors: Patricia Gómez-Suaga, Beatriz G. Pérez-Nievas, Elizabeth B. Glennon, Dawn H. W. Lau, Sebastien Paillusson, Gábor M. Mórotz, Tito Calì, Paola Pizzo, Wendy Noble and Christopher C. J. Miller

    Citation: Acta Neuropathologica Communications 2019 7:35

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  21. Content type: Research

    Pathological tau aggregates in Alzheimer’s disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau specific monoclonal antibody (mAb) GT-38 t...

    Authors: Garrett S. Gibbons, Soo-Jung Kim, John L. Robinson, Lakshmi Changolkar, David J. Irwin, Leslie M. Shaw, Virginia M.-Y. Lee and John Q. Trojanowski

    Citation: Acta Neuropathologica Communications 2019 7:34

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  22. Content type: Research

    Next-generation sequencing platforms are routinely used for molecular assignment due to their high impact for risk stratification and prognosis in medulloblastomas. Yet, low and middle-income countries still l...

    Authors: Gustavo Alencastro Veiga Cruzeiro, Karina Bezerra Salomão, Carlos Alberto Oliveira de Biagi Jr, Martin Baumgartner, Dominik Sturm, Régia Caroline Peixoto Lira, Taciani de Almeida Magalhães, Mirella Baroni Milan, Vanessa da Silva Silveira, Fabiano Pinto Saggioro, Ricardo Santos de Oliveira, Paulo Henrique dos Santos Klinger, Ana Luiza Seidinger, José Andrés Yunes, Rosane Gomes de Paula Queiroz, Sueli Mieko Oba-Shinjo…

    Citation: Acta Neuropathologica Communications 2019 7:33

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  23. Content type: Review

    Insights into tau molecular structures have advanced significantly in recent years. This field has been the subject of recent breakthroughs, including the first cryo-electron microscopy structures of tau filam...

    Authors: Yann Fichou, Youssra K. Al-Hilaly, François Devred, Caroline Smet-Nocca, Philipp O. Tsvetkov, Joke Verelst, Joris Winderickx, Nick Geukens, Eugeen Vanmechelen, Audrey Perrotin, Louise Serpell, Bernard J Hanseeuw, Miguel Medina, Luc Buée and Isabelle Landrieu

    Citation: Acta Neuropathologica Communications 2019 7:31

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  24. Content type: Research

    TRIM32 is a E3 ubiquitin -ligase containing RING, B-box, coiled-coil and six C-terminal NHL domains. Mutations involving NHL and coiled-coil domains result in a pure myopathy (LGMD2H/STM) while the only descri...

    Authors: E. Servián-Morilla, M. Cabrera-Serrano, E. Rivas-Infante, A. Carvajal, P. J. Lamont, A. L. Pelayo-Negro, G. Ravenscroft, R. Junckerstorff, J. M. Dyke, S. Fletcher, A. M. Adams, F. Mavillard, M. A. Fernández-García, J. L. Nieto-González, N. G. Laing and C. Paradas

    Citation: Acta Neuropathologica Communications 2019 7:30

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  25. Content type: Research

    The deposition of tau pathology in Alzheimer’s disease (AD) may occur first in axons of neurons and then progress back into the cell bodies to form neurofibrillary tangles, however, studies have not directly a...

    Authors: Kyle R. Christensen, Thomas G. Beach, Geidy E. Serrano and Nicholas M. Kanaan

    Citation: Acta Neuropathologica Communications 2019 7:29

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  26. Content type: Research

    Mutations in leucine-rich repeat kinase 2 (LRRK2) are one of the most common causes of familial Parkinson’s disease (PD). The most common mutations in the LRRK2 gene induce elevated kinase activity of the LRRK2 p...

    Authors: Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski and Virginia M. Y. Lee

    Citation: Acta Neuropathologica Communications 2019 7:28

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  27. Content type: Research

    The fragile X premutation is a CGG trinucleotide repeat expansion between 55 and 200 repeats in the 5′-untranslated region of the fragile X mental retardation 1 (FMR1) gene. Human carriers of the premutation alle...

    Authors: H. Jürgen Wenzel, Karl D. Murray, Saif N. Haify, Michael R. Hunsaker, Jared J. Schwartzer, Kyoungmi Kim, Albert R. La Spada, Bryce L. Sopher, Paul J. Hagerman, Christopher Raske, Lies-Anne W.F.M. Severijnen, Rob Willemsen, Renate K. Hukema and Robert F. Berman

    Citation: Acta Neuropathologica Communications 2019 7:27

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  28. Content type: Research

    Cerebral amyloid angiopathy (CAA) is typified by the cerebrovascular deposition of amyloid. Currently, there is no clear understanding of the mechanisms underlying the contribution of CAA to neurodegeneration....

    Authors: Yingjian You, Abigail Perkins, Pablo Cisternas, Braulio Muñoz, Xavier Taylor, Yanwen You, Holly J. Garringer, Adrian L. Oblak, Brady K. Atwood, Ruben Vidal and Cristian A. Lasagna-Reeves

    Citation: Acta Neuropathologica Communications 2019 7:26

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  29. Content type: Research

    The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 syn...

    Authors: Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry and Mariana Vargas-Caballero

    Citation: Acta Neuropathologica Communications 2019 7:25

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  30. Content type: Research

    The introduction of the classification of brain tumours based on their DNA methylation profile has significantly changed the diagnostic approach for cases with ambiguous histology, non-informative or contradic...

    Authors: Zane Jaunmuktane, David Capper, David T. W. Jones, Daniel Schrimpf, Martin Sill, Monika Dutt, Nirosha Suraweera, Stefan M. Pfister, Andreas von Deimling and Sebastian Brandner

    Citation: Acta Neuropathologica Communications 2019 7:24

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  31. Content type: Research

    At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibi...

    Authors: Abhijit Nirwane, Jessica Johnson, Benjamin Nguyen, Jeffrey H. Miner and Yao Yao

    Citation: Acta Neuropathologica Communications 2019 7:23

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  32. Content type: Review

    Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer’s disease and related human tauopathies. There is a growing body of evidence indicating that pathological tau species can travel ...

    Authors: Santosh Jadhav, Jesus Avila, Michael Schöll, Gabor G. Kovacs, Enikö Kövari, Rostislav Skrabana, Lewis D Evans, Eva Kontsekova, Barbara Malawska, Rohan de Silva, Luc Buee and Norbert Zilka

    Citation: Acta Neuropathologica Communications 2019 7:22

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  33. Content type: Research

    PP2A is a major regulator of tau phosphorylation, which is principally regulated by an endogenous nuclear protein inhibitor 2 of PP2A (I2PP2A), also named SET. However, how SET is post-translationally regulated a...

    Authors: Min Qin, Honglian Li, Jian Bao, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Bin Zhang, Xiji Shu and Xiaochuan Wang

    Citation: Acta Neuropathologica Communications 2019 7:21

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  34. Content type: Research

    Monocytes/macrophages have begun to emerge as key cellular modulators of brain homeostasis and central nervous system (CNS) disease. In the healthy brain, resident microglia are the predominant macrophage cell...

    Authors: Verena Haage, Marcus Semtner, Ramon Oliveira Vidal, Daniel Perez Hernandez, Winnie W. Pong, Zhihong Chen, Dolores Hambardzumyan, Vincent Magrini, Amy Ly, Jason Walker, Elaine Mardis, Philipp Mertins, Sascha Sauer, Helmut Kettenmann and David H. Gutmann

    Citation: Acta Neuropathologica Communications 2019 7:20

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  35. Content type: Research

    Frontotemporal lobar degeneration (FTLD) is pathologically subdivided based on the presence of particular pathological proteins that are identified in inclusion bodies observed post-mortem. The FTLD-FUS subgro...

    Authors: Lauren M. Gittings, Sandrine C. Foti, Bridget C. Benson, Priya Gami-Patel, Adrian M. Isaacs and Tammaryn Lashley

    Citation: Acta Neuropathologica Communications 2019 7:18

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  36. Content type: Research

    In the setting of stroke, ischemia-related blood-brain barrier (BBB) dysfunction aggravates the cerebral edema, which critically impacts on the clinical outcome. Further, an impaired vascular integrity is asso...

    Authors: Martin Krueger, Bianca Mages, Constance Hobusch and Dominik Michalski

    Citation: Acta Neuropathologica Communications 2019 7:17

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  37. Content type: Research

    Previous studies suggest white matter (WM) integrity is vulnerable to chronic hypoperfusion during brain ageing. We assessed ~ 0.7 million capillary profiles in the frontal lobe WM across several dementias com...

    Authors: Yoshiki Hase, Ren Ding, Gina Harrison, Emily Hawthorne, Amilia King, Sean Gettings, Charlotte Platten, William Stevenson, Lucinda J. L. Craggs and Raj N. Kalaria

    Citation: Acta Neuropathologica Communications 2019 7:16

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  38. Content type: Research

    Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. ...

    Authors: Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff and Reiner Kunze

    Citation: Acta Neuropathologica Communications 2019 7:15

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  39. Content type: Research

    Human inflammatory or neurodegenerative diseases, such as progressive multiple sclerosis (MS), occur on a background of age-related microglia activation and iron accumulation as well as pre-existing neurodegen...

    Authors: Isabella Wimmer, Cornelia Scharler, Tobias Zrzavy, Taro Kadowaki, Verena Mödlagl, Kim Rojc, Anna R. Tröscher, Maja Kitic, Shuichi Ueda, Monika Bradl and Hans Lassmann

    Citation: Acta Neuropathologica Communications 2019 7:14

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  40. Content type: Research

    The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the...

    Authors: Hermeto Gerber, Sebastien Mosser, Benjamin Boury-Jamot, Michael Stumpe, Alessandra Piersigilli, Christine Goepfert, Joern Dengjel, Urs Albrecht, Fulvio Magara and Patrick C. Fraering

    Citation: Acta Neuropathologica Communications 2019 7:13

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  41. Content type: Research

    Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA hav...

    Authors: Yoshinori Endo, Kazuhiro Hasegawa, Ryo Nomura, Hidetaka Arishima, Ken-ichiro Kikuta, Taro Yamashita, Yasuteru Inoue, Mitsuharu Ueda, Yukio Ando, Mark R. Wilson, Tadanori Hamano, Yasunari Nakamoto and Hironobu Naiki

    Citation: Acta Neuropathologica Communications 2019 7:12

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  42. Content type: Research

    Early in the development of multiple sclerosis (MS) and its mouse model experimental autoimmune encephalomyelitis (EAE), vascular integrity is compromised. This is accompanied by a marked vascular remodeling r...

    Authors: Ravi Kant, Sebok K. Halder, Gregory J. Bix and Richard Milner

    Citation: Acta Neuropathologica Communications 2019 7:11

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  43. Content type: Research

    Pathogenic mutations in the tau gene (microtubule associated protein tau, MAPT) are linked to the onset of tauopathy, but the A152T variant is unique in acting as a risk factor for a range of disorders including ...

    Authors: Yari Carlomagno, Dah-eun Chloe Chung, Mei Yue, Aishe Kurti, Nicole M. Avendano, Monica Castanedes-Casey, Kelly M. Hinkle, Karen Jansen-West, Lillian M. Daughrity, Jimei Tong, Virginia Phillips, Rosa Rademakers, Michael DeTure, John D. Fryer, Dennis W. Dickson, Leonard Petrucelli…

    Citation: Acta Neuropathologica Communications 2019 7:10

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  44. Content type: Research

    The endogenous cholinergic system plays a key role in neuronal cells, by suppressing neurite outgrowth and myelination and, in some cancer cells, favoring tumor growth. Platinum compounds are widely used as pa...

    Authors: Olivier Cerles, Tânia Cristina Gonçalves, Sandrine Chouzenoux, Evelyne Benoit, Alain Schmitt, Nathaniel Edward Bennett Saidu, Niloufar Kavian, Christiane Chéreau, Camille Gobeaux, Bernard Weill, Romain Coriat, Carole Nicco and Frédéric Batteux

    Citation: Acta Neuropathologica Communications 2019 7:9

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  45. Content type: Research

    Levodopa-induced dyskinesias (LID) are a prevalent side effect of chronic treatment with levodopa (L-DOPA) for the motor symptoms of Parkinson’s disease (PD). It has long been hypothesized that serotonergic ne...

    Authors: Rhyomi C. Sellnow, Jordan H. Newman, Nicole Chambers, Anthony R. West, Kathy Steece-Collier, Ivette M. Sandoval, Matthew J. Benskey, Christopher Bishop and Fredric P. Manfredsson

    Citation: Acta Neuropathologica Communications 2019 7:8

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  46. Content type: Research

    Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. FUS is an essential componen...

    Authors: Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman and Tatyana A. Shelkovnikova

    Citation: Acta Neuropathologica Communications 2019 7:7

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