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  1. Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling...

    Authors: Nadine A Hoffmann, Mario M Dorostkar, Sonja Blumenstock, Michel Goedert and Jochen Herms
    Citation: Acta Neuropathologica Communications 2013 1:82
  2. A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged diseas...

    Authors: Mee-Ohk Kim, Ignazio Cali, Abby Oehler, Jamie C Fong, Katherine Wong, Tricia See, Jonathan S Katz, Pierluigi Gambetti, Brianne M Bettcher, Stephen J DeArmond and Michael D Geschwind
    Citation: Acta Neuropathologica Communications 2013 1:80
  3. Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of ...

    Authors: Darius Ebrahimi-Fakhari, Laiq-Jan Saidi and Lara Wahlster
    Citation: Acta Neuropathologica Communications 2013 1:79
  4. In human and animal prion diseases, pathological prion protein, PrPSc, as well as prion infectivity is mainly found in the central nervous system, but also in lymphoid organs and muscle. Pathophysiology of prion ...

    Authors: Melanie Neumann, Susanne Krasemann, Katharina Schröck, Karin Steinbach and Markus Glatzel
    Citation: Acta Neuropathologica Communications 2013 1:78
  5. The deposition of the amyloid β-peptide (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). It is not yet clear whether Aβ always leads to similar changes or whether it induces different fea...

    Authors: Ajeet Rijal Upadhaya, Frederik Scheibe, Irina Kosterin, Dorothee Abramowski, Janina Gerth, Sathish Kumar, Stefan Liebau, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel and Dietmar Rudolf Thal
    Citation: Acta Neuropathologica Communications 2013 1:77
  6. One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidos...

    Authors: Claudia Duran-Aniotz, Rodrigo Morales, Ines Moreno-Gonzalez, Ping Ping Hu and Claudio Soto
    Citation: Acta Neuropathologica Communications 2013 1:76
  7. The Blood–brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides. The neurovascular unit (NVU) couples vascular a...

    Authors: Ayman ElAli, Peter Thériault, Paul Préfontaine and Serge Rivest
    Citation: Acta Neuropathologica Communications 2013 1:75
  8. Sporadic Creutzfeldt-Jakob disease is classified according to the genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 or 2) of abnormal isoform of PrP (PrPSc) in the brain. ...

    Authors: Atsushi Kobayashi, Yasushi Iwasaki, Hiroyuki Otsuka, Masahito Yamada, Mari Yoshida, Yuichi Matsuura, Shirou Mohri and Tetsuyuki Kitamoto
    Citation: Acta Neuropathologica Communications 2013 1:74
  9. Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies...

    Authors: Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez and Javier Vitorica
    Citation: Acta Neuropathologica Communications 2013 1:73
  10. Human prion diseases are a group of rare fatal neurodegenerative conditions with well-developed clinical and neuropathological diagnostic criteria. Recent observations have expanded the spectrum of prion disea...

    Authors: Gabor G Kovacs, Alexander Peden, Serge Weis, Romana Höftberger, Anna S Berghoff, Helen Yull, Thomas Ströbel, Stefan Koppi, Regina Katzenschlager, Dieter Langenscheidt, Hamid Assar, Elisabeth Zaruba, Albrecht Gröner, Till Voigtländer, Gina Puska, Eva Hametner…
    Citation: Acta Neuropathologica Communications 2013 1:72
  11. Rupture of a saccular intracranial aneurysm (sIA) causes an often fatal subarachnoid hemorrhage (SAH). Why some sIAs rupture remains unknown. Since sIA walls bear some histological similarities with early athe...

    Authors: Juhana Frösen, Riikka Tulamo, Tommi Heikura, Sini Sammalkorpi, Mika Niemelä, Juha Hernesniemi, Anna-Liisa Levonen, Sohvi Hörkkö and Seppo Ylä-Herttuala
    Citation: Acta Neuropathologica Communications 2013 1:71
  12. Neuronal activity intimately communicates with blood flow through the blood–brain barrier (BBB) in the central nervous system (CNS). Astrocyte endfeet cover more than 90% of brain capillaries and interact with...

    Authors: Peter Jukkola, Tomas Guerrero, Victoria Gray and Chen Gu
    Citation: Acta Neuropathologica Communications 2013 1:70
  13. Cerebellar hemorrhagic injury (CHI) is being recognized more frequently in premature infants. However, much of what we know about CHI neuropathology is from autopsy studies that date back to a prior era of neo...

    Authors: Krista M Haines, Wei Wang and Christopher R Pierson
    Citation: Acta Neuropathologica Communications 2013 1:69
  14. Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, ...

    Authors: David MA Mann, Sara Rollinson, Andrew Robinson, Janis Bennion Callister, Jennifer C Thompson, Julie S Snowden, Tania Gendron, Leonard Petrucelli, Masami Masuda-Suzukake, Masato Hasegawa, Yvonne Davidson and Stuart Pickering-Brown
    Citation: Acta Neuropathologica Communications 2013 1:68
  15. Previous reports indicate the presence of histological abnormalities in the brains of individuals with autism spectrum disorders (ASD) suggestive of a dysplastic process. In this study we identified areas of a...

    Authors: Manuel F Casanova, Ayman S El-Baz, Shweta S Kamat, Brynn A Dombroski, Fahmi Khalifa, Ahmed Elnakib, Ahmed Soliman, Anita Allison-McNutt and Andrew E Switala
    Citation: Acta Neuropathologica Communications 2013 1:67
  16. Medulloblastoma is the most common malignant brain tumor in children. Genetic profiling has identified four principle tumor subgroups; each subgroup is characterized by different initiating mutations, genetic ...

    Authors: Kelsey L Whittier, Erin A Boese, Katherine N Gibson-Corley, Patricia A Kirby, Benjamin W Darbro, Qining Qian, Wendy J Ingram, Thomas Robertson, Marc Remke, Michael D Taylor and M Sue O’Dorisio
    Citation: Acta Neuropathologica Communications 2013 1:66
  17. Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical and ...

    Authors: Jon B Toledo, Nigel J Cairns, Xiao Da, Kewei Chen, Deborah Carter, Adam Fleisher, Erin Householder, Napatkamon Ayutyanont, Auttawut Roontiva, Robert J Bauer, Paul Eisen, Leslie M Shaw, Christos Davatzikos, Michael W Weiner, Eric M Reiman, John C Morris…
    Citation: Acta Neuropathologica Communications 2013 1:65
  18. There is an emerging association between ketamine abuse and the development of urological symptoms including dysuria, frequency and urgency, which have a neurological component. In addition, extreme cases are ...

    Authors: Simon C Baker, Jens Stahlschmidt, Jon Oxley, Jennifer Hinley, Ian Eardley, Fiona Marsh, David Gillatt, Simon Fulford and Jennifer Southgate
    Citation: Acta Neuropathologica Communications 2013 1:64
  19. Congenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss (SNHL). The mechanisms of pathogenesis of CMV-related SNHL are still unclear. The aim is to study congenital CMV-rela...

    Authors: Liliana Gabrielli, Maria Paola Bonasoni, Donatella Santini, Giulia Piccirilli, Angela Chiereghin, Brunella Guerra, Maria Paola Landini, Maria Grazia Capretti, Marcello Lanari and Tiziana Lazzarotto
    Citation: Acta Neuropathologica Communications 2013 1:63
  20. For the last 20 years, the “amyloid cascade hypothesis” has dominated research aimed at understanding, preventing, and curing Alzheimer’s disease (AD). During that time researchers have acquired an enormous am...

    Authors: Dimitrije Krstic and Irene Knuesel
    Citation: Acta Neuropathologica Communications 2013 1:62
  21. Autism is a neurodevelopmental disorder of unknown etiopathogenesis associated with structural and functional abnormalities of neurons and increased formation of reactive oxygen species. Our previous study rev...

    Authors: Janusz Frackowiak, Bozena Mazur-Kolecka, N Carolyn Schanen, W Ted Brown and Jerzy Wegiel
    Citation: Acta Neuropathologica Communications 2013 1:61
  22. The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here w...

    Authors: Hannu Kalimo, Maciej Lalowski, Nenad Bogdanovic, Ola Philipson, Thomas D Bird, David Nochlin, Gerard D Schellenberg, RoseMarie Brundin, Tommie Olofsson, Rabah Soliymani, Marc Baumann, Oliver Wirths, Thomas A Bayer, Lars NG Nilsson, Hans Basun, Lars Lannfelt…
    Citation: Acta Neuropathologica Communications 2013 1:60
  23. Axon degeneration, a key pathological event in many neurodegenerative diseases and injury, can be induced by somatodendritic excitotoxin exposure. It is currently unclear, however, whether excitotoxin-induced ...

    Authors: Anna Elizabeth King, Katherine Adriana Southam, Justin Dittmann and James Clement Vickers
    Citation: Acta Neuropathologica Communications 2013 1:59
  24. Cobblestone lissencephaly is a severe neuronal migration disorder associated with congenital muscular dystrophies (CMD) such as Walker-Warburg syndrome, muscle-eye-brain disease, and Fukuyama-type CMD. In thes...

    Authors: Huy Nguyen, Adam P Ostendorf, Jakob S Satz, Steve Westra, Susan E Ross-Barta, Kevin P Campbell and Steven A Moore
    Citation: Acta Neuropathologica Communications 2013 1:58
  25. Persistent neuroinflammation and disruptions in brain energy metabolism is commonly seen in traumatic brain injury (TBI). Because of the lack of success of most TBI interventions and the documented benefits of...

    Authors: Teresita L Briones, Julie Woods and Magdalena Rogozinska
    Citation: Acta Neuropathologica Communications 2013 1:57
  26. The amyloid hypothesis in Alzheimer disease (AD) considers amyloid β peptide (Aβ) deposition causative in triggering down-stream events like neurofibrillary tangles, cell loss, vascular damage and memory decli...

    Authors: Gregory Antonios, Nasrin Saiepour, Yvonne Bouter, Bernhard C Richard, Anders Paetau, Auli Verkkoniemi-Ahola, Lars Lannfelt, Martin Ingelsson, Gabor G Kovacs, Thierry Pillot, Oliver Wirths and Thomas A Bayer
    Citation: Acta Neuropathologica Communications 2013 1:56
  27. The pathological features of the common neurodegenerative conditions, Alzheimer’s disease (AD), Parkinson’s disease and multiple sclerosis are all known to be associated with iron dysregulation in regions of t...

    Authors: Animesh Alexander Raha, Radhika Anand Vaishnav, Robert Paul Friedland, Adrian Bomford and Ruma Raha-Chowdhury
    Citation: Acta Neuropathologica Communications 2013 1:55
  28. Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different disease...

    Authors: Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David MA Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama and Masato Hasegawa
    Citation: Acta Neuropathologica Communications 2013 1:54
  29. In theory, cerebral biopsies could provide the diagnosis in a significant proportion of patients with neurodegenerative diseases, however, there are considerable ethical barriers. Previous series of cerebral b...

    Authors: Andrew King, Satomi Maekawa, Istvan Bodi, Claire Troakes, Olimpia Curran, Keyoumars Ashkan and Safa Al-Sarraj
    Citation: Acta Neuropathologica Communications 2013 1:53
  30. Blast-induced neurotrauma (BINT) is the signature life threatening injury of current military casualties. Neuroinflammation is a key pathological occurrence of secondary injury contributing to brain damage aft...

    Authors: Yansong Li, Mikulas Chavko, Jessica L Slack, Bin Liu, Richard M McCarron, James D Ross and Jurandir J Dalle Lucca
    Citation: Acta Neuropathologica Communications 2013 1:52
  31. Blast-related traumatic brain injury (TBI) has been a significant cause of injury in the military operations of Iraq and Afghanistan, affecting as many as 10-20% of returning veterans. However, how blast waves...

    Authors: Miguel A Gama Sosa, Rita De Gasperi, Alejandro J Paulino, Paul E Pricop, Michael C Shaughness, Eric Maudlin-Jeronimo, Aaron A Hall, William G M Janssen, Frank J Yuk, Nathan P Dorr, Dara L Dickstein, Richard M McCarron, Mikulas Chavko, Patrick R Hof, Stephen T Ahlers and Gregory A Elder
    Citation: Acta Neuropathologica Communications 2013 1:51
  32. We have sought histological evidence, using TDP-43 and p62 immunohistochemistry, for the presence of expansions in C9ORF72 among 200 patients with pathologically confirmed AD.

    Authors: Yvonne S Davidson, Andrew C Robinson, Julie S Snowden and David MA Mann
    Citation: Acta Neuropathologica Communications 2013 1:50
  33. TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative ...

    Authors: Rui Liu, Guang Yang, Takashi Nonaka, Tetsuaki Arai, William Jia and Max S Cynader
    Citation: Acta Neuropathologica Communications 2013 1:49
  34. Basement membranes in the walls of cerebral capillaries and arteries form a major lymphatic drainage pathway for fluid and solutes from the brain. Amyloid-β (Aβ) draining from the brain is deposited in such pe...

    Authors: Roxana Octavia Carare, Jessica Liesbeth Teeling, Cheryl A Hawkes, Ursula Püntener, Roy O Weller, James AR Nicoll and Victor Hugh Perry
    Citation: Acta Neuropathologica Communications 2013 1:48
  35. Focal cortical dysplasias (FCD) are local disturbances of neocortical architecture and a common cause of pharmaco-resistant focal epilepsy. Little is known about the pathomechanisms leading to architectural ab...

    Authors: Susanne Fauser, Ute Häussler, Catharina Donkels, Susanne Huber, Julia Nakagawa, Marco Prinz, Andreas Schulze-Bonhage, Josef Zentner and Carola A Haas
    Citation: Acta Neuropathologica Communications 2013 1:47
  36. Presenilin-1 (PS1) is the active component of the amyloid precursor protein cleaving γ-secretase complex. PS1 protein is a transmembrane protein containing multiple hydrophobic regions which presence in cerebr...

    Authors: María-Salud García-Ayllón, María-Letizia Campanari, Gunnar Brinkmalm, Alberto Rábano, Jordi Alom, Carlos A Saura, Niels Andreasen, Kaj Blennow and Javier Sáez-Valero
    Citation: Acta Neuropathologica Communications 2013 1:46
  37. Monosomy 1p36 is the most common subtelomeric chromosomal deletion linked to mental retardation and seizures. Neuroimaging studies suggest that monosomy 1p36 is associated with brain malformations including po...

    Authors: Naoko Shiba, Ray AM Daza, Lisa G Shaffer, A James Barkovich, William B Dobyns and Robert F Hevner
    Citation: Acta Neuropathologica Communications 2013 1:45
  38. PrPSc, the only known constituent of prions, the infectious agents causing prion diseases, can be detected by real-time quaking-induced conversion (RT-QuIC). However, there is no efficient method to quantify the ...

    Authors: Song Shi, Gerda Mitteregger-Kretzschmar, Armin Giese and Hans A Kretzschmar
    Citation: Acta Neuropathologica Communications 2013 1:44
  39. Foamy macrophages, containing myelin degradation products, are abundantly found in active multiple sclerosis (MS) lesions. Recent studies have described an altered phenotype of macrophages after myelin interna...

    Authors: Jeroen FJ Bogie, Winde Jorissen, Jo Mailleux, Philip G Nijland, Noam Zelcer, Tim Vanmierlo, Jack Van Horssen, Piet Stinissen, Niels Hellings and Jerome JA Hendriks
    Citation: Acta Neuropathologica Communications 2013 1:43
  40. A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caus...

    Authors: Axel Freischmidt, Kathrin Müller, Albert C Ludolph and Jochen H Weishaupt
    Citation: Acta Neuropathologica Communications 2013 1:42
  41. Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this ou...

    Authors: Orwa Aboud, Robert E Mrak, Frederick A Boop and W Sue T Griffin
    Citation: Acta Neuropathologica Communications 2013 1:41
  42. Central pontine myelinolysis (CPM) is a demyelinating disorder of the central basis pontis that is often associated with osmotic stress. The aquaporin water channels (AQPs) have been pathogenically implicated ...

    Authors: Bogdan F Gh Popescu, Reem F Bunyan, Yong Guo, Joseph E Parisi, Vanda A Lennon and Claudia F Lucchinetti
    Citation: Acta Neuropathologica Communications 2013 1:40
  43. Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth fac...

    Authors: Pan Pan and Rick T Dobrowsky
    Citation: Acta Neuropathologica Communications 2013 1:39
  44. α-Synuclein (αS) is the major component of several types of brain inclusions including Lewy bodies, a hallmark of Parkinson’s disease. Aberrant aggregation of αS also is associated with cellular demise in mult...

    Authors: Amanda N Sacino, Mieu Brooks, Nicholas H McGarvey, Alex B McKinney, Michael A Thomas, Yona Levites, Yong Ran, Todd E Golde and Benoit I Giasson
    Citation: Acta Neuropathologica Communications 2013 1:38
  45. Calreticulin (CRT) is a chaperone protein, which aids correct folding of glycosylated proteins in the endoplasmic reticulum (ER). Under conditions of ER stress, CRT is upregulated and may be displayed on the s...

    Authors: Mary Ní Fhlathartaigh, Jill McMahon, Richard Reynolds, David Connolly, Eibhlín Higgins, Timothy Counihan and Una FitzGerald
    Citation: Acta Neuropathologica Communications 2013 1:37
  46. Frontotemporal lobar degeneration (FTLD) is the second most common cause of dementia in individuals under 65 years old and manifests as alterations in behavior, personality, or language secondary to degenerati...

    Authors: Johanna I Busch, Maria Martinez-Lage, Emily Ashbridge, Murray Grossman, Vivianna M Van Deerlin, Fenghua Hu, Virginia MY Lee, John Q Trojanowski and Alice S Chen-Plotkin
    Citation: Acta Neuropathologica Communications 2013 1:36
  47. Medulloblastomas, the most frequent malignant brain tumours affecting children, comprise at least 4 distinct clinicogenetic subgroups. Aberrant sonic hedgehog (SHH) signalling is observed in approximately 25% ...

    Authors: Maria Łastowska, Hani Al-Afghani, Haya H Al-Balool, Harsh Sheth, Emma Mercer, Jonathan M Coxhead, Chris PF Redfern, Heiko Peters, Alastair D Burt, Mauro Santibanez-Koref, Chris M Bacon, Louis Chesler, Alistair G Rust, David J Adams, Daniel Williamson, Steven C Clifford…
    Citation: Acta Neuropathologica Communications 2013 1:35
  48. Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal deme...

    Authors: Josien Levenga, Pavan Krishnamurthy, Hameetha Rajamohamedsait, Helen Wong, Thomas F Franke, Peter Cain, Einar M Sigurdsson and Charles A Hoeffer
    Citation: Acta Neuropathologica Communications 2013 1:34
  49. Two commercially available TDP43 antibodies (phosphorylated or pTDP43, non-phosphorylated or iTDP43) are currently in use for the neuropathological classification of FTLD-TDP cases into pathological subtypes. ...

    Authors: Rachel H Tan, Claire E Shepherd, Jillian J Kril, Heather McCann, Andrew McGeachie, Ciara McGinley, Andrew Affleck and Glenda M Halliday
    Citation: Acta Neuropathologica Communications 2013 1:33

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