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  1. Synaptic dysfunction and synapse loss are key features of Alzheimer’s pathogenesis. Previously, we showed an essential function of APP and APLP2 for synaptic plasticity, learning and memory. Here, we used orga...

    Authors: Sascha W Weyer, Marta Zagrebelsky, Ulrike Herrmann, Meike Hick, Lennard Ganss, Julia Gobbert, Morna Gruber, Christine Altmann, Martin Korte, Thomas Deller and Ulrike C Müller
    Citation: Acta Neuropathologica Communications 2014 2:36
  2. The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic of amyotrophic lateral sclerosis (ALS) and the majority of frontotemporal lobar degeneration (FTLD-TDP) refe...

    Authors: Linda K Kwong, David J Irwin, Adam K Walker, Yan Xu, Dawn M Riddle, John Q Trojanowski and Virginia M Y Lee
    Citation: Acta Neuropathologica Communications 2014 2:33
  3. A major neuropathological hallmark of Alzheimer’s disease is the deposition of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β-amyloid, which is a cleavage ...

    Authors: Steffen Burgold, Severin Filser, Mario M Dorostkar, Boris Schmidt and Jochen Herms
    Citation: Acta Neuropathologica Communications 2014 2:30
  4. The accumulation of misfolded proteins appears as a fundamental pathogenic process in human neurodegenerative diseases. In the case of synucleinopathies such as Parkinson’s disease (PD) or dementia with Lewy b...

    Authors: Dominique Bétemps, Jérémy Verchère, Sébastien Brot, Eric Morignat, Luc Bousset, Damien Gaillard, Latifa Lakhdar, Ronald Melki and Thierry Baron
    Citation: Acta Neuropathologica Communications 2014 2:29
  5. Several morphometric studies have revealed smaller than normal neurons in the neocortex of autistic subjects. To test the hypothesis that abnormal neuronal growth is a marker of an autism-associated global enc...

    Authors: Jerzy Wegiel, Michael Flory, Izabela Kuchna, Krzysztof Nowicki, Shuang Yong Ma, Humi Imaki, Jarek Wegiel, Ira L Cohen, Eric London, W Ted Brown and Thomas Wisniewski
    Citation: Acta Neuropathologica Communications 2014 2:28
  6. Natalizumab blocks α4-integrins and is a prototypic agent for a series of anti-inflammatory drugs that impair trafficking of immune cells into the CNS. However, modulation of the access of immune cells to the ...

    Authors: Veit Rothhammer, Andreas Muschaweckh, Georg Gasteiger, Franziska Petermann, Sylvia Heink, Dirk H Busch, Mathias Heikenwälder, Bernhard Hemmer, Ingo Drexler and Thomas Korn
    Citation: Acta Neuropathologica Communications 2014 2:27
  7. Based on previous studies, a preclinical classification for Alzheimer’s disease (AD) has been proposed. However, 1) specificity of the different neuronal injury (NI) biomarkers has not been studied, 2) subject...

    Authors: Jon B Toledo, Michael W Weiner, David A Wolk, Xiao Da, Kewei Chen, Steven E Arnold, William Jagust, Clifford Jack, Eric M Reiman, Christos Davatzikos, Leslie M Shaw and John Q Trojanowski
    Citation: Acta Neuropathologica Communications 2014 2:26
  8. Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but the...

    Authors: Alexandra Grubman, Grace E Lidgerwood, Clare Duncan, Laura Bica, Jiang-Li Tan, Sarah J Parker, Aphrodite Caragounis, Jodi Meyerowitz, Irene Volitakis, Diane Moujalled, Jeffrey R Liddell, James L Hickey, Malcolm Horne, Shoshanah Longmuir, Jari Koistinaho, Paul S Donnelly…
    Citation: Acta Neuropathologica Communications 2014 2:25
  9. We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60’s followed by memory impairment, low mood and recurrent falls. Examination shortly befo...

    Authors: Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino, Henry Houlden, John Hardy and Janice L Holton
    Citation: Acta Neuropathologica Communications 2014 2:24
  10. Paediatric high grade glioma (pHGG) is a distinct biological entity to histologically similar tumours arising in older adults, and has differing copy number profiles and driver genetic alterations. As function...

    Authors: Diana Carvalho, Alan Mackay, Lynn Bjerke, Richard G Grundy, Celeste Lopes, Rui M Reis and Chris Jones
    Citation: Acta Neuropathologica Communications 2014 2:23
  11. The progression of Alzheimer’s disease (AD) is associated with an increase of phosphorylated tau in the brain. One of the earliest phosphorylated sites on tau is Ser262 that is preferentially phosphorylated by mi...

    Authors: Harald Lund, Elin Gustafsson, Anne Svensson, Maria Nilsson, Margareta Berg, Dan Sunnemark and Gabriel von Euler
    Citation: Acta Neuropathologica Communications 2014 2:22
  12. Microglial activation is a pathological feature common to both Alzheimer’s and Parkinson’s diseases (AD and PD). The classical activation involves release of pro-inflammatory cytokines and reactive oxygen spec...

    Authors: Peixuan Pey, Ronald KB Pearce, Michail E Kalaitzakis, W Sue T Griffin and Steve M Gentleman
    Citation: Acta Neuropathologica Communications 2014 2:21
  13. Mutations in the gene for alpha-galactosidase A result in Fabry disease, a rare, X-linked lysosomal storage disorder characterized by a loss of alpha-galactosidase A enzymatic activity. The resultant accumulat...

    Authors: Michael P Nelson, Tonia E Tse, Darrel B O’Quinn, Stefanie M Percival, Edgar A Jaimes, David G Warnock and John J Shacka
    Citation: Acta Neuropathologica Communications 2014 2:20
  14. IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in cod...

    Authors: Stefan Pusch, Leonille Schweizer, Ann-Christin Beck, Johanna-Marie Lehmler, Susanne Weissert, Jörg Balss, Aubry K Miller and Andreas von Deimling
    Citation: Acta Neuropathologica Communications 2014 2:19
  15. Gangliogliomas are low-grade glioneuronal tumors of the central nervous system and the commonest cause of chronic intractable epilepsy. Most gangliogliomas (>70%) arise in the temporal lobe, and infratentorial...

    Authors: Kirti Gupta, Wilda Orisme, Julie H Harreld, Ibrahim Qaddoumi, James D Dalton, Chandanamali Punchihewa, Racquel Collins-Underwood, Thomas Robertson, Ruth G Tatevossian and David W Ellison
    Citation: Acta Neuropathologica Communications 2014 2:18
  16. The progressive development of Alzheimer’s disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the...

    Authors: Sonia George, Annica Rönnbäck, Gunnar K Gouras, Géraldine H Petit, Fiona Grueninger, Bengt Winblad, Caroline Graff and Patrik Brundin
    Citation: Acta Neuropathologica Communications 2014 2:17
  17. Axon degeneration is a characteristic feature of multiple neuropathologic states and is also a mechanism of physiological neurodevelopmental pruning. The vast majority of in vivo studies looking at axon degenerat...

    Authors: Jennifer D Sokolowski, Kanchana K Gamage, Daniel S Heffron, Andrea C LeBlanc, Christopher D Deppmann and James W Mandell
    Citation: Acta Neuropathologica Communications 2014 2:16
  18. Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the...

    Authors: Jonathan M Bleasel, Joanna H Wong, Glenda M Halliday and Woojin Scott Kim
    Citation: Acta Neuropathologica Communications 2014 2:15
  19. In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration ...

    Authors: Simon Dujardin, Katia Lécolle, Raphaëlle Caillierez, Séverine Bégard, Nadège Zommer, Cédrick Lachaud, Sébastien Carrier, Noëlle Dufour, Gwennaëlle Aurégan, Joris Winderickx, Philippe Hantraye, Nicole Déglon, Morvane Colin and Luc Buée
    Citation: Acta Neuropathologica Communications 2014 2:14
  20. Metabolic stroke is the rapid onset of lasting central neurological deficit associated with decompensation of an underlying metabolic disorder. Glutaric aciduria type I (GA1) is an inherited disorder of lysine...

    Authors: William J Zinnanti, Jelena Lazovic, Cathy Housman, David A Antonetti, David M Koeller, James R Connor and Lawrence Steinman
    Citation: Acta Neuropathologica Communications 2014 2:13
  21. The accumulation of beta amyloid (Aβ) peptides, a hallmark of Alzheimer’s disease (AD) is related to mechanisms leading to neurodegeneration. Among its pleiotropic cellular effects, Aβ accumulation has been as...

    Authors: Johnatan Ceccom, Najat Loukh, Valérie Lauwers-Cances, Christian Touriol, Yvan Nicaise, Catherine Gentil, Emmanuelle Uro-Coste, Stuart Pitson, Claude Alain Maurage, Charles Duyckaerts, Olivier Cuvillier and Marie-Bernadette Delisle
    Citation: Acta Neuropathologica Communications 2014 2:12
  22. Fundamental cytological changes of amyotrophic lateral sclerosis (ALS) were looked for by comparing relatively preserved Onuf’s nucleus (ON) and severely affected neighboring motor neuron groups (dorsolateral ...

    Authors: Takahiro Takeda, Toshiki Uchihara, Yuki Nakayama, Ayako Nakamura, Shoichi Sasaki, Shinji Kakei, Shinichiro Uchiyama, Charles Duyckaerts and Mari Yoshida
    Citation: Acta Neuropathologica Communications 2014 2:11
  23. Medulloblastoma is the most common intracranial childhood malignancy and a genetically heterogeneous disease. Despite recent advances, current therapeutic approaches are still associated with high morbidity an...

    Authors: Ashirwad Merve, Adrian M Dubuc, Xinyu Zhang, Marc Remke, Patricia A Baxter, Xiao-Nan Li, Michael D Taylor and Silvia Marino
    Citation: Acta Neuropathologica Communications 2014 2:10
  24. The greatest genetic risk factor for late-onset Alzheimer's disease (AD) is the ϵ4 allele of Apolipoprotein E (ApoE). ApoE regulates secretion of the potent neuroprotective signaling lipid Sphingosine 1-phosph...

    Authors: Timothy A Couttas, Nupur Kain, Benjamin Daniels, Xin Ying Lim, Claire Shepherd, Jillian Kril, Russell Pickford, Hongyun Li, Brett Garner and Anthony S Don
    Citation: Acta Neuropathologica Communications 2014 2:9
  25. In humans and animals, prion protein (PrP) is usually expressed as a glycophosphatidylinositol (GPI)-anchored membrane protein, but anchorless PrP may be pathogenic in humans with certain familial prion diseas...

    Authors: Alejandra Rangel, Brent Race, Katie Phillips, James Striebel, Nancy Kurtz and Bruce Chesebro
    Citation: Acta Neuropathologica Communications 2014 2:8
  26. An unusual multinodular and vacuolating neuronal tumour (MVNT) has been described in the cerebral hemispheres of ten patients with adult-onset seizures. We report the findings in two cases with similar feature...

    Authors: Istvan Bodi, Olimpia Curran, Richard Selway, Robert Elwes, Juan Burrone, Ross Laxton, Safa Al-Sarraj and Mrinalini Honavar
    Citation: Acta Neuropathologica Communications 2014 2:7
  27. Spontaneous autoimmune peripheral neuropathy including Guillain-Barré Syndrome (GBS) represents as one of the serious emergencies in neurology. Although pathological changes have been well documented, molecula...

    Authors: Mu Yang, Anthony Rainone, Xiang Qun Shi, Sylvie Fournier and Ji Zhang
    Citation: Acta Neuropathologica Communications 2014 2:5
  28. Induced pluripotent stem cells (iPSCs) derived from patients with neurodegenerative disease generally lack neuropathological confirmation, the gold standard for disease classification and grading of severity. ...

    Authors: Andrew A Sproul, Lauren B Vensand, Carmen R Dusenberry, Samson Jacob, Jean Paul G Vonsattel, Daniel J Paull, Michael L Shelanski, John F Crary and Scott A Noggle
    Citation: Acta Neuropathologica Communications 2014 2:4
  29. Multiple sclerosis (MS) is characterized by central nervous system inflammation and demyelination, and increasing evidence demonstrates significant neuronal damage also occurs and is associated with permanent ...

    Authors: Reas S Khan, Kimberly Dine, Jayasri Das Sarma and Kenneth S Shindler
    Citation: Acta Neuropathologica Communications 2014 2:3
  30. Pompe disease, an inherited deficiency of lysosomal acid alpha-glucosidase (GAA), is a metabolic myopathy with heterogeneous clinical presentations. Late-onset Pompe disease (LOPD) is a debilitating progressiv...

    Authors: Erin J Feeney, Stephanie Austin, Yin-Hsiu Chien, Hanna Mandel, Benedikt Schoser, Sean Prater, Wuh-Liang Hwu, Evelyn Ralston, Priya S Kishnani and Nina Raben
    Citation: Acta Neuropathologica Communications 2014 2:2
  31. Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. T...

    Authors: Ka Yu Yeung, Adam Dickinson, Jacqueline F Donoghue, Galina Polekhina, Stefan J White, Dimitris K Grammatopoulos, Matthew McKenzie, Terrance G Johns and Justin C St John
    Citation: Acta Neuropathologica Communications 2014 2:1
  32. Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in ...

    Authors: Maria Pohl, Naoto Kawakami, Maja Kitic, Jan Bauer, Rui Martins, Marie-Therese Fischer, Joana Machado-Santos, Simone Mader, Joachim W Ellwart, Tatsuro Misu, Kazuo Fujihara, Hartmut Wekerle, Markus Reindl, Hans Lassmann and Monika Bradl
    Citation: Acta Neuropathologica Communications 2013 1:85
  33. Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal sub...

    Authors: David W Hampton, Andrea Serio, Gareth Pryce, Sarah Al-Izki, Robin JM Franklin, Gavin Giovannoni, David Baker and Siddharthan Chandran
    Citation: Acta Neuropathologica Communications 2013 1:84
  34. Alzheimer’s disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Aβ) fibrils. Copper has been implicated to play ...

    Authors: Youssra K Al-Hilaly, Thomas L Williams, Maris Stewart-Parker, Lenzie Ford, Eldhose Skaria, Michael Cole, William Grant Bucher, Kyle L Morris, Alaa Abdul Sada, Julian R Thorpe and Louise C Serpell
    Citation: Acta Neuropathologica Communications 2013 1:83
  35. Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling...

    Authors: Nadine A Hoffmann, Mario M Dorostkar, Sonja Blumenstock, Michel Goedert and Jochen Herms
    Citation: Acta Neuropathologica Communications 2013 1:82
  36. A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged diseas...

    Authors: Mee-Ohk Kim, Ignazio Cali, Abby Oehler, Jamie C Fong, Katherine Wong, Tricia See, Jonathan S Katz, Pierluigi Gambetti, Brianne M Bettcher, Stephen J DeArmond and Michael D Geschwind
    Citation: Acta Neuropathologica Communications 2013 1:80
  37. Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of ...

    Authors: Darius Ebrahimi-Fakhari, Laiq-Jan Saidi and Lara Wahlster
    Citation: Acta Neuropathologica Communications 2013 1:79
  38. In human and animal prion diseases, pathological prion protein, PrPSc, as well as prion infectivity is mainly found in the central nervous system, but also in lymphoid organs and muscle. Pathophysiology of prion ...

    Authors: Melanie Neumann, Susanne Krasemann, Katharina Schröck, Karin Steinbach and Markus Glatzel
    Citation: Acta Neuropathologica Communications 2013 1:78
  39. The deposition of the amyloid β-peptide (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). It is not yet clear whether Aβ always leads to similar changes or whether it induces different fea...

    Authors: Ajeet Rijal Upadhaya, Frederik Scheibe, Irina Kosterin, Dorothee Abramowski, Janina Gerth, Sathish Kumar, Stefan Liebau, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel and Dietmar Rudolf Thal
    Citation: Acta Neuropathologica Communications 2013 1:77
  40. One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidos...

    Authors: Claudia Duran-Aniotz, Rodrigo Morales, Ines Moreno-Gonzalez, Ping Ping Hu and Claudio Soto
    Citation: Acta Neuropathologica Communications 2013 1:76
  41. The Blood–brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides. The neurovascular unit (NVU) couples vascular a...

    Authors: Ayman ElAli, Peter Thériault, Paul Préfontaine and Serge Rivest
    Citation: Acta Neuropathologica Communications 2013 1:75
  42. Sporadic Creutzfeldt-Jakob disease is classified according to the genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 or 2) of abnormal isoform of PrP (PrPSc) in the brain. ...

    Authors: Atsushi Kobayashi, Yasushi Iwasaki, Hiroyuki Otsuka, Masahito Yamada, Mari Yoshida, Yuichi Matsuura, Shirou Mohri and Tetsuyuki Kitamoto
    Citation: Acta Neuropathologica Communications 2013 1:74
  43. Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies...

    Authors: Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez and Javier Vitorica
    Citation: Acta Neuropathologica Communications 2013 1:73
  44. Human prion diseases are a group of rare fatal neurodegenerative conditions with well-developed clinical and neuropathological diagnostic criteria. Recent observations have expanded the spectrum of prion disea...

    Authors: Gabor G Kovacs, Alexander Peden, Serge Weis, Romana Höftberger, Anna S Berghoff, Helen Yull, Thomas Ströbel, Stefan Koppi, Regina Katzenschlager, Dieter Langenscheidt, Hamid Assar, Elisabeth Zaruba, Albrecht Gröner, Till Voigtländer, Gina Puska, Eva Hametner…
    Citation: Acta Neuropathologica Communications 2013 1:72
  45. Rupture of a saccular intracranial aneurysm (sIA) causes an often fatal subarachnoid hemorrhage (SAH). Why some sIAs rupture remains unknown. Since sIA walls bear some histological similarities with early athe...

    Authors: Juhana Frösen, Riikka Tulamo, Tommi Heikura, Sini Sammalkorpi, Mika Niemelä, Juha Hernesniemi, Anna-Liisa Levonen, Sohvi Hörkkö and Seppo Ylä-Herttuala
    Citation: Acta Neuropathologica Communications 2013 1:71
  46. Neuronal activity intimately communicates with blood flow through the blood–brain barrier (BBB) in the central nervous system (CNS). Astrocyte endfeet cover more than 90% of brain capillaries and interact with...

    Authors: Peter Jukkola, Tomas Guerrero, Victoria Gray and Chen Gu
    Citation: Acta Neuropathologica Communications 2013 1:70
  47. Cerebellar hemorrhagic injury (CHI) is being recognized more frequently in premature infants. However, much of what we know about CHI neuropathology is from autopsy studies that date back to a prior era of neo...

    Authors: Krista M Haines, Wei Wang and Christopher R Pierson
    Citation: Acta Neuropathologica Communications 2013 1:69
  48. Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, ...

    Authors: David MA Mann, Sara Rollinson, Andrew Robinson, Janis Bennion Callister, Jennifer C Thompson, Julie S Snowden, Tania Gendron, Leonard Petrucelli, Masami Masuda-Suzukake, Masato Hasegawa, Yvonne Davidson and Stuart Pickering-Brown
    Citation: Acta Neuropathologica Communications 2013 1:68

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