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  1. Content type: Research

    Here, we assessed unique brain tissue samples, obtained from living subjects with idiopathic Normal Pressure Hydrocephalus (iNPH). Our cohort of 95 subjects with age ranging from 75 to 79 years, displayed a hi...

    Authors: Sylwia Libard and Irina Alafuzoff

    Citation: Acta Neuropathologica Communications 2019 7:98

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    The Publisher Correction to this article has been published in Acta Neuropathologica Communications 2019 7:131

  2. Content type: Research

    Despite their phenotypic heterogeneity, most human prion diseases belong to two broadly defined groups: Creutzfeldt-Jakob disease (CJD) and Gerstmann-Sträussler-Scheinker disease (GSS). While the structural ch...

    Authors: Laura Cracco, Xiangzhu Xiao, Satish K. Nemani, Jody Lavrich, Ignazio Cali, Bernardino Ghetti, Silvio Notari, Witold K. Surewicz and Pierluigi Gambetti

    Citation: Acta Neuropathologica Communications 2019 7:85

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    The Publisher Correction to this article has been published in Acta Neuropathologica Communications 2019 7:131

  3. Content type: Research

    Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and animals. Both were viewed to be rather independent events in disease pathophysiology, with proinflammatory microglia consi...

    Authors: Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel and Susanne Krasemann

    Citation: Acta Neuropathologica Communications 2019 7:83

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  4. Content type: Research

    Microglia affect Alzheimer’s disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages. Recent res...

    Authors: T. L. Stephen, M. Cacciottolo, D. Balu, T. E. Morgan, M. J. LaDu, C. E. Finch and C. J. Pike

    Citation: Acta Neuropathologica Communications 2019 7:82

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  5. Content type: Research

    Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion...

    Authors: Zuzana Krejciova, George A. Carlson, Kurt Giles and Stanley B. Prusiner

    Citation: Acta Neuropathologica Communications 2019 7:81

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  6. Content type: Research

    α-synuclein (αS) is the major component of several types of brain pathological inclusions that define neurodegenerative diseases termed synucleinopathies. Central nervous system (CNS) inoculation studies using...

    Authors: Jess-Karan S. Dhillon, Jorge A. Trejo-Lopez, Cara Riffe, Yona Levites, Amanda N. Sacino, David R. Borchelt, Anthony Y. Yachnis and Benoit I. Giasson

    Citation: Acta Neuropathologica Communications 2019 7:80

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  7. Content type: Research

    Pathogenic variants of the huntingtin (HTT) protein and their aggregation have been investigated in great detail in brains of Huntington’s disease patients and HTT-transgenic animals. However, little is known ...

    Authors: Maike Hartlage-Rübsamen, Veronika Ratz, Ulrike Zeitschel, Lukas Finzel, Lisa Machner, Janett Köppen, Anja Schulze, Hans-Ulrich Demuth, Stephan von Hörsten, Corinna Höfling and Steffen Roßner

    Citation: Acta Neuropathologica Communications 2019 7:79

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  8. Content type: Case report

    The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral hemispheres of teenagers and young adults, and have a generally adverse...

    Authors: Felipe Andreiuolo, Tomo Lisner, Jozef Zlocha, Christof Kramm, Arend Koch, Brigitte Bison, Albane Gareton, Marc Zanello, Andreas Waha, Pascale Varlet and Torsten Pietsch

    Citation: Acta Neuropathologica Communications 2019 7:78

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  9. Content type: Research

    The maintenance of genomic integrity is essential for normal cellular functions. However, it is difficult to maintain over a lifetime in postmitotic cells such as neurons, in which DNA damage increases with ag...

    Authors: Niraj M. Shanbhag, Mark D. Evans, Wenjie Mao, Alissa L. Nana, William W. Seeley, Anthony Adame, Robert A. Rissman, Eliezer Masliah and Lennart Mucke

    Citation: Acta Neuropathologica Communications 2019 7:77

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  10. Content type: Research

    Diffuse intrinsic pontine glioma (DIPG), an infiltrative, high grade glioma (HGG) affecting young children, has the highest mortality rate of all pediatric cancers. Despite treatment, average survival is less ...

    Authors: J. Qi, D. R. Esfahani, T. Huang, P. Ozark, E. Bartom, R. Hashizume, E. R. Bonner, S. An, C. M. Horbinski, C. D. James and A. M. Saratsis

    Citation: Acta Neuropathologica Communications 2019 7:75

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  11. Content type: Research

    Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer’s disease (AD) and other neurol...

    Authors: Alex J. Smith, Tianjiao Duan and Alan S. Verkman

    Citation: Acta Neuropathologica Communications 2019 7:74

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  12. Content type: Research

    Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 ...

    Authors: Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble and Christopher C. J. Miller

    Citation: Acta Neuropathologica Communications 2019 7:73

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  13. Content type: Research

    Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer’s disease (AD). Tau derived from AD patients’ brains induces tau aggregation in a prion-like manner when injected into susceptible mo...

    Authors: Zhiva Skachokova, Alfonso Martinisi, Martin Flach, Frederik Sprenger, Yvonne Naegelin, Viviane Steiner-Monard, Marc Sollberger, Andreas U. Monsch, Michel Goedert, Markus Tolnay and David T. Winkler

    Citation: Acta Neuropathologica Communications 2019 7:72

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  14. Content type: Research

    Neurofibrillary tangles (NFTs), are shared between progressive supranuclear palsy (PSP) and Alzheimer disease (AD). Histological distinction of PSP and AD is possible based on the distribution of NFTs. However...

    Authors: Momoko Ebashi, Yoshinori Ito, Miho Uematsu, Ayako Nakamura, Katsuiku Hirokawa, Satoshi Kamei and Toshiki Uchihara

    Citation: Acta Neuropathologica Communications 2019 7:71

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  15. Content type: Letter to the Editor

    Authors: Giorgio Giaccone, Emanuela Maderna, Gianluca Marucci, Marcella Catania, Alessandra Erbetta, Luisa Chiapparini, Antonio Indaco, Paola Caroppo, Anna Bersano, Eugenio Parati, Giuseppe Di Fede and Luigi Caputi

    Citation: Acta Neuropathologica Communications 2019 7:70

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  16. Content type: Research

    Pituicytoma is a rare, poorly characterized tumor of the sellar region that is thought to be derived from neurohypophyseal pituicytes. Resection of pituicytomas is often associated with significant morbidity i...

    Authors: Angela N. Viaene, Edward B. Lee, Jason N. Rosenbaum, Ilya M. Nasrallah and MacLean P. Nasrallah

    Citation: Acta Neuropathologica Communications 2019 7:69

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  17. Content type: Research

    Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD) and further suggests that several PD-related genes are responsible for ER dysfunction. How...

    Authors: Jee Hoon Lee, Ji-hye Han, Hyunmi Kim, Sang Myun Park, Eun-hye Joe and Ilo Jou

    Citation: Acta Neuropathologica Communications 2019 7:68

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  18. Content type: Research

    Meningiomas are the most common primary brain tumor of adults. The majority are benign (WHO grade I), with a mostly indolent course; 20% of them (WHO grade II and III) are, however, considered aggressive and r...

    Authors: Angela N. Viaene, Bo Zhang, Maria Martinez-Lage, Chaomei Xiang, Umberto Tosi, Jayesh P. Thawani, Busra Gungor, Yuankun Zhu, Laura Roccograndi, Logan Zhang, Robert L. Bailey, Phillip B. Storm, Donald M. O’Rourke, Adam C. Resnick, M. Sean Grady and Nadia Dahmane

    Citation: Acta Neuropathologica Communications 2019 7:67

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  19. Content type: Research

    Phosphatidylinositol 3-kinase signaling promotes cell growth and survival and is frequently activated in infiltrative gliomas. Activating mutations in PIK3CA gene are observed in 6–15% of glioblastomas, although ...

    Authors: Shota Tanaka, Tracy T. Batchelor, A. John Iafrate, Dora Dias-Santagata, Darrell R. Borger, Leif W. Ellisen, Daniel Yang, David N. Louis, Daniel P. Cahill and Andrew S. Chi

    Citation: Acta Neuropathologica Communications 2019 7:66

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  20. Content type: Research

    RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for...

    Authors: Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski and Nancy M. Bonini

    Citation: Acta Neuropathologica Communications 2019 7:65

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  21. Content type: Research

    Pediatric high grade gliomas (pHGG), including diffuse intrinsic pontine gliomas (DIPGs), are aggressive tumors with a dismal outcome. Radiotherapy (RT) is part of the standard of care of these tumors; however...

    Authors: Naiara Martinez-Velez, Miguel Marigil, Marc García-Moure, Marisol Gonzalez-Huarriz, Jose Javier Aristu, Luis-Isaac Ramos-García, Sonia Tejada, Ricardo Díez-Valle, Ana Patiño-García, Oren J. Becher, Candelaria Gomez-Manzano, Juan Fueyo and Marta M. Alonso

    Citation: Acta Neuropathologica Communications 2019 7:64

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  22. Content type: Research

    The discovery of an expanded (GGGGCC)n repeat (termed G4C2) within the first intron of C9orf72 in familial ALS/FTD has led to a number of studies showing that the aberrant expression of G4C2 RNA can produce toxic...

    Authors: Lindsey D. Goodman, Mercedes Prudencio, Ananth R. Srinivasan, Olivia M. Rifai, Virginia M.-Y. Lee, Leonard Petrucelli and Nancy M. Bonini

    Citation: Acta Neuropathologica Communications 2019 7:62

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  23. Content type: Research

    Although the precise neuropathological substrates of cognitive decline in Parkinson’s disease (PD) remain elusive, it has long been regarded that pathology in the CA2 hippocampal subfield is characteristic of ...

    Authors: Alan King Lun Liu, Tsz Wing Chau, Ernest Junwei Lim, Idil Ahmed, Raymond Chuen-Chung Chang, Michail E. Kalaitzakis, Manuel B. Graeber, Steve M. Gentleman and Ronald K. B. Pearce

    Citation: Acta Neuropathologica Communications 2019 7:61

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  24. Content type: Research

    Inter-individual differences in cortisol production by the hypothalamus–pituitary–adrenal (HPA) axis are thought to contribute to clinical and pathological heterogeneity of multiple sclerosis (MS). At the same...

    Authors: Jeroen Melief, Marie Orre, Koen Bossers, Corbert G. van Eden, Karianne G. Schuurman, Matthew R. J. Mason, Joost Verhaagen, Jörg Hamann and Inge Huitinga

    Citation: Acta Neuropathologica Communications 2019 7:60

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  25. Content type: Research

    Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptio...

    Authors: H. Binder, E. Willscher, H. Loeffler-Wirth, L. Hopp, D. T. W. Jones, S. M. Pfister, M. Kreuz, D. Gramatzki, E. Fortenbacher, B. Hentschel, M. Tatagiba, U. Herrlinger, H. Vatter, J. Matschke, M. Westphal, D. Krex…

    Citation: Acta Neuropathologica Communications 2019 7:59

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  26. Content type: Research

    The heterogeneity of multiple sclerosis is reflected by dynamic changes of different lesion types in the brain white matter (WM). To identify potential drivers of this process, we RNA-sequenced 73 WM areas fro...

    Authors: Maria L. Elkjaer, Tobias Frisch, Richard Reynolds, Tim Kacprowski, Mark Burton, Torben A. Kruse, Mads Thomassen, Jan Baumbach and Zsolt Illes

    Citation: Acta Neuropathologica Communications 2019 7:58

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    The Retraction Note to this article has been published in Acta Neuropathologica Communications 2019 7:136

  27. Content type: Research

    Parkinson’s disease is characterized by a proteinopathy that includes aggregates of α-synuclein. A recent hypothesis proposes a prion-like spreading mechanism for this α-synucleinopathy. Early neuropathologica...

    Authors: Alicia Flores-Cuadrado, Daniel Saiz-Sanchez, Alicia Mohedano-Moriano, Alino Martinez-Marcos and Isabel Ubeda-Bañon

    Citation: Acta Neuropathologica Communications 2019 7:56

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  28. Content type: Research

    Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetrat...

    Authors: Terje Sundstrøm, Lars Prestegarden, Francisco Azuaje, Synnøve Nymark Aasen, Gro Vatne Røsland, Jobin K. Varughese, Marzieh Bahador, Simon Bernatz, Yannick Braun, Patrick N. Harter, Kai Ove Skaftnesmo, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah Tam, Clifford G. Tepper, Kjell Petersen…

    Citation: Acta Neuropathologica Communications 2019 7:55

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  29. Content type: Research

    Recently, moderate prenatal alcohol exposure (PAE) was shown to be a risk factor for peripheral neuropathy following minor nerve injury. This effect coincides with elevated spinal cord astrocyte activation and...

    Authors: Joshua J. Sanchez, Jacob E. Sanchez, Shahani Noor, Chaselyn D. Ruffaner-Hanson, Suzy Davies, Carston R. Wagner, Lauren L. Jantzie, Nikolaos Mellios, Daniel D. Savage and Erin D. Milligan

    Citation: Acta Neuropathologica Communications 2019 7:54

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  30. Content type: Research

    Current evidence indicating a role of the human prion protein (PrP) in amyloid-beta (Aβ) formation or a synergistic effect between Aβ and prion pathology remains controversial. Conflicting results also concern...

    Authors: Marcello Rossi, Hideaki Kai, Simone Baiardi, Anna Bartoletti-Stella, Benedetta Carlà, Corrado Zenesini, Sabina Capellari, Tetsuyuki Kitamoto and Piero Parchi

    Citation: Acta Neuropathologica Communications 2019 7:53

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  31. Content type: Research

    Genome-wide expression profiling studies have identified four core molecular subgroups of medulloblastoma: WNT, SHH, Group 3 and Group 4. Molecular markers are necessary for accurate risk stratification in the...

    Authors: Harish Shrikrishna Bharambe, Raikamal Paul, Pooja Panwalkar, Rakesh Jalali, Epari Sridhar, Tejpal Gupta, Aliasgar Moiyadi, Prakash Shetty, Sadaf Kazi, Akash Deogharkar, Shalaka Masurkar, Kedar Yogi, Ratika Kunder, Nikhil Gadewal, Atul Goel, Naina Goel…

    Citation: Acta Neuropathologica Communications 2019 7:52

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  32. Content type: Research

    Brain water homeostasis is essential for the appropriate control of neuronal activity. Furthermore, the encasement of the central nervous system (CNS) by a hard structure, greatly limits its tolerance for the ...

    Authors: Claudia Palazzo, Cinzia Buccoliero, Maria Grazia Mola, Pasqua Abbrescia, Grazia Paola Nicchia, Maria Trojano and Antonio Frigeri

    Citation: Acta Neuropathologica Communications 2019 7:51

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  33. Content type: Research

    TAR DNA-binding protein (TDP-43) is a ubiquitously expressed nuclear protein, which participates in a number of cellular processes and has been identified as the major pathological factor in amyotrophic lateral s...

    Authors: Lien-Szu Wu, Wei-Cheng Cheng, Chia-Ying Chen, Ming-Che Wu, Yi-Chi Wang, Yu-Hsiang Tseng, Trees-Juen Chuang and C.-K. James Shen

    Citation: Acta Neuropathologica Communications 2019 7:50

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  34. Content type: Research

    A previous study reported that a massive cerebral infarct in the territory of the middle cerebral artery (MCA) may be associated with development of neurofibrillary tangles (NFTs) in the ipsilateral basal nucl...

    Authors: Hiroyuki Hatsuta, Masaki Takao, Akane Nogami, Akiko Uchino, Hiroyuki Sumikura, Tadayuki Takata, Satoru Morimoto, Kazutomi Kanemaru, Tadashi Adachi, Tomio Arai, Masato Hasegawa and Shigeo Murayama

    Citation: Acta Neuropathologica Communications 2019 7:49

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  35. Content type: Research

    Degeneration of photoreceptors in the retina is a major cause of blindness in humans. Often retinal degeneration is due to inheritance of mutations in genes important in photoreceptor (PR) function, but can al...

    Authors: James F. Striebel, Brent Race, Katie Williams, James A. Carroll, Mikael Klingeborn and Bruce Chesebro

    Citation: Acta Neuropathologica Communications 2019 7:48

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  36. Content type: Research

    Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer’s disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in...

    Authors: Benoît Souchet, Mickael Audrain, Jean Marie Billard, Julien Dairou, Romain Fol, Nicola Salvatore Orefice, Satoru Tada, Yuchen Gu, Gaelle Dufayet-Chaffaud, Emmanuelle Limanton, François Carreaux, Jean-Pierre Bazureau, Sandro Alves, Laurent Meijer, Nathalie Janel, Jérôme Braudeau…

    Citation: Acta Neuropathologica Communications 2019 7:46

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  37. Content type: Research

    Over the past two decades a number of studies have demonstrated activity of the retroviral enzyme reverse transcriptase in the serum of patients with sporadic amyotrophic lateral sclerosis (ALS). Known human exog...

    Authors: Jeremy A. Garson, Louise Usher, Ammar Al-Chalabi, Jim Huggett, Edmund F. Day and Adele L. McCormick

    Citation: Acta Neuropathologica Communications 2019 7:45

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    The Letter to the Editor to this article has been published in Acta Neuropathologica Communications 2019 7:101

  38. Content type: Research

    A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also exhibit dysfunction and death of brain cells. However, ...

    Authors: Jennifer A. Macdonald, Iraad F. Bronner, Lesley Drynan, Juan Fan, Annabelle Curry, Graham Fraser, Isabelle Lavenir and Michel Goedert

    Citation: Acta Neuropathologica Communications 2019 7:44

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  39. Content type: Research

    Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We a...

    Authors: Norman L. Lehman, Aisulu Usubalieva, Tong Lin, Sariah J. Allen, Quynh T. Tran, Bret C. Mobley, Roger E. McLendon, Matthew J. Schniederjan, Maria-Magdalena Georgescu, Marta Couce, Mohanpal S. Dulai, Jack M. Raisanen, Mousa Al Abbadi, Cheryl A. Palmer, Eyas M. Hattab and Brent A. Orr

    Citation: Acta Neuropathologica Communications 2019 7:42

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  40. Content type: Research

    Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but t...

    Authors: Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore and Jiyan Ma

    Citation: Acta Neuropathologica Communications 2019 7:41

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  41. Content type: Research

    Autism is a neurodevelopmental connectivity disorder characterized by cortical network disorganization and imbalance in excitation/inhibition. However, little is known about the development of autism pathology...

    Authors: Iris Margalit Trutzer, Miguel Ángel García-Cabezas and Basilis Zikopoulos

    Citation: Acta Neuropathologica Communications 2019 7:40

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  42. Content type: Research

    Human homologue of yeast UV excision repair protein Rad23b (HR23B) inclusions are found in a number of neurodegenerative diseases, including frontotemporal dementia (FTD), Huntington’s disease (HD), spinocereb...

    Authors: Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten and Rob Willemsen

    Citation: Acta Neuropathologica Communications 2019 7:39

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  43. Content type: Research

    Encephalitis with anti-NMDAR antibodies (NMDAR-E) is a severe autoimmune neurological disorder, defined by a clinical presentation of encephalitis and the presence of IgG targeting the GluN1 subunit of NMDA re...

    Authors: Aude Chefdeville, Isabelle Treilleux, Marie-Eve Mayeur, Coline Couillault, Géraldine Picard, Chloé Bost, Karima Mokhtari, Alexandre Vasiljevic, David Meyronet, Véronique Rogemond, Dimitri Psimaras, Bertrand Dubois, Jérôme Honnorat and Virginie Desestret

    Citation: Acta Neuropathologica Communications 2019 7:38

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  44. Content type: Research

    [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection...

    Authors: Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch and Teresa Gomez-Isla

    Citation: Acta Neuropathologica Communications 2019 7:37

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  45. Content type: Research

    Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform...

    Authors: Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson and Leonard Petrucelli

    Citation: Acta Neuropathologica Communications 2019 7:36

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