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Page 18 of 19

  1. Multiple sclerosis (MS) is characterized by central nervous system inflammation and demyelination, and increasing evidence demonstrates significant neuronal damage also occurs and is associated with permanent ...

    Authors: Reas S Khan, Kimberly Dine, Jayasri Das Sarma and Kenneth S Shindler

    Citation: Acta Neuropathologica Communications 2014 2:3

    Content type: Research

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  2. Pompe disease, an inherited deficiency of lysosomal acid alpha-glucosidase (GAA), is a metabolic myopathy with heterogeneous clinical presentations. Late-onset Pompe disease (LOPD) is a debilitating progressiv...

    Authors: Erin J Feeney, Stephanie Austin, Yin-Hsiu Chien, Hanna Mandel, Benedikt Schoser, Sean Prater, Wuh-Liang Hwu, Evelyn Ralston, Priya S Kishnani and Nina Raben

    Citation: Acta Neuropathologica Communications 2014 2:2

    Content type: Research

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  3. Mitochondrial DNA (mtDNA) encodes key proteins of the electron transfer chain (ETC), which produces ATP through oxidative phosphorylation (OXPHOS) and is essential for cells to perform specialised functions. T...

    Authors: Ka Yu Yeung, Adam Dickinson, Jacqueline F Donoghue, Galina Polekhina, Stefan J White, Dimitris K Grammatopoulos, Matthew McKenzie, Terrance G Johns and Justin C St John

    Citation: Acta Neuropathologica Communications 2014 2:1

    Content type: Research

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  4. Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS), which is characterized by the presence of pathogenic serum autoantibodies against aquaporin 4 (AQP4) in ...

    Authors: Maria Pohl, Naoto Kawakami, Maja Kitic, Jan Bauer, Rui Martins, Marie-Therese Fischer, Joana Machado-Santos, Simone Mader, Joachim W Ellwart, Tatsuro Misu, Kazuo Fujihara, Hartmut Wekerle, Markus Reindl, Hans Lassmann and Monika Bradl

    Citation: Acta Neuropathologica Communications 2013 1:85

    Content type: Research

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  5. Multiple Sclerosis has two clinical phases reflecting distinct but inter-related pathological processes: focal inflammation drives the relapse-remitting stage and neurodegeneration represents the principal sub...

    Authors: David W Hampton, Andrea Serio, Gareth Pryce, Sarah Al-Izki, Robin JM Franklin, Gavin Giovannoni, David Baker and Siddharthan Chandran

    Citation: Acta Neuropathologica Communications 2013 1:84

    Content type: Research

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  6. Alzheimer’s disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Aβ) fibrils. Copper has been implicated to play ...

    Authors: Youssra K Al-Hilaly, Thomas L Williams, Maris Stewart-Parker, Lenzie Ford, Eldhose Skaria, Michael Cole, William Grant Bucher, Kyle L Morris, Alaa Abdul Sada, Julian R Thorpe and Louise C Serpell

    Citation: Acta Neuropathologica Communications 2013 1:83

    Content type: Research

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  7. Illuminating the role of the microtubule-associated protein tau in neurodegenerative diseases is of increasing importance, supported by recent studies establishing novel functions of tau in synaptic signalling...

    Authors: Nadine A Hoffmann, Mario M Dorostkar, Sonja Blumenstock, Michel Goedert and Jochen Herms

    Citation: Acta Neuropathologica Communications 2013 1:82

    Content type: Research

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  8. A novel point mutation resulting in a glutamate-to-glycine substitution in PRNP at codon 200, E200G with codon 129 MV polymorphism (cis valine) and type 2 PrPSc was identified in a patient with a prolonged diseas...

    Authors: Mee-Ohk Kim, Ignazio Cali, Abby Oehler, Jamie C Fong, Katherine Wong, Tricia See, Jonathan S Katz, Pierluigi Gambetti, Brianne M Bettcher, Stephen J DeArmond and Michael D Geschwind

    Citation: Acta Neuropathologica Communications 2013 1:80

    Content type: Case report

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  9. Changes in protein metabolism are key to disease onset and progression in many neurodegenerative diseases. As a prime example, in Parkinson’s disease, folding, post-translational modification and recycling of ...

    Authors: Darius Ebrahimi-Fakhari, Laiq-Jan Saidi and Lara Wahlster

    Citation: Acta Neuropathologica Communications 2013 1:79

    Content type: Review

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  10. In human and animal prion diseases, pathological prion protein, PrPSc, as well as prion infectivity is mainly found in the central nervous system, but also in lymphoid organs and muscle. Pathophysiology of prion ...

    Authors: Melanie Neumann, Susanne Krasemann, Katharina Schröck, Karin Steinbach and Markus Glatzel

    Citation: Acta Neuropathologica Communications 2013 1:78

    Content type: Research

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  11. The deposition of the amyloid β-peptide (Aβ) in the brain is one of the hallmarks of Alzheimer’s disease (AD). It is not yet clear whether Aβ always leads to similar changes or whether it induces different fea...

    Authors: Ajeet Rijal Upadhaya, Frederik Scheibe, Irina Kosterin, Dorothee Abramowski, Janina Gerth, Sathish Kumar, Stefan Liebau, Haruyasu Yamaguchi, Jochen Walter, Matthias Staufenbiel and Dietmar Rudolf Thal

    Citation: Acta Neuropathologica Communications 2013 1:77

    Content type: Research

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  12. One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidos...

    Authors: Claudia Duran-Aniotz, Rodrigo Morales, Ines Moreno-Gonzalez, Ping Ping Hu and Claudio Soto

    Citation: Acta Neuropathologica Communications 2013 1:76

    Content type: Research

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  13. The Blood–brain barrier (BBB) controls brain supply with oxygen and nutrients, and protects the brain from toxic metabolites, such as beta-amyloid (Aβ) peptides. The neurovascular unit (NVU) couples vascular a...

    Authors: Ayman ElAli, Peter Thériault, Paul Préfontaine and Serge Rivest

    Citation: Acta Neuropathologica Communications 2013 1:75

    Content type: Research

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  14. Sporadic Creutzfeldt-Jakob disease is classified according to the genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 or 2) of abnormal isoform of PrP (PrPSc) in the brain. ...

    Authors: Atsushi Kobayashi, Yasushi Iwasaki, Hiroyuki Otsuka, Masahito Yamada, Mari Yoshida, Yuichi Matsuura, Shirou Mohri and Tetsuyuki Kitamoto

    Citation: Acta Neuropathologica Communications 2013 1:74

    Content type: Research

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  15. Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies...

    Authors: Laura Trujillo-Estrada, Sebastian Jimenez, Vanessa De Castro, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Victoria Navarro, Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez and Javier Vitorica

    Citation: Acta Neuropathologica Communications 2013 1:73

    Content type: Research

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  16. Human prion diseases are a group of rare fatal neurodegenerative conditions with well-developed clinical and neuropathological diagnostic criteria. Recent observations have expanded the spectrum of prion disea...

    Authors: Gabor G Kovacs, Alexander Peden, Serge Weis, Romana Höftberger, Anna S Berghoff, Helen Yull, Thomas Ströbel, Stefan Koppi, Regina Katzenschlager, Dieter Langenscheidt, Hamid Assar, Elisabeth Zaruba, Albrecht Gröner, Till Voigtländer, Gina Puska, Eva Hametner…

    Citation: Acta Neuropathologica Communications 2013 1:72

    Content type: Research

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  17. Rupture of a saccular intracranial aneurysm (sIA) causes an often fatal subarachnoid hemorrhage (SAH). Why some sIAs rupture remains unknown. Since sIA walls bear some histological similarities with early athe...

    Authors: Juhana Frösen, Riikka Tulamo, Tommi Heikura, Sini Sammalkorpi, Mika Niemelä, Juha Hernesniemi, Anna-Liisa Levonen, Sohvi Hörkkö and Seppo Ylä-Herttuala

    Citation: Acta Neuropathologica Communications 2013 1:71

    Content type: Research

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  18. Neuronal activity intimately communicates with blood flow through the blood–brain barrier (BBB) in the central nervous system (CNS). Astrocyte endfeet cover more than 90% of brain capillaries and interact with...

    Authors: Peter Jukkola, Tomas Guerrero, Victoria Gray and Chen Gu

    Citation: Acta Neuropathologica Communications 2013 1:70

    Content type: Research

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  19. Cerebellar hemorrhagic injury (CHI) is being recognized more frequently in premature infants. However, much of what we know about CHI neuropathology is from autopsy studies that date back to a prior era of neo...

    Authors: Krista M Haines, Wei Wang and Christopher R Pierson

    Citation: Acta Neuropathologica Communications 2013 1:69

    Content type: Research

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  20. Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, ...

    Authors: David MA Mann, Sara Rollinson, Andrew Robinson, Janis Bennion Callister, Jennifer C Thompson, Julie S Snowden, Tania Gendron, Leonard Petrucelli, Masami Masuda-Suzukake, Masato Hasegawa, Yvonne Davidson and Stuart Pickering-Brown

    Citation: Acta Neuropathologica Communications 2013 1:68

    Content type: Research

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  21. Previous reports indicate the presence of histological abnormalities in the brains of individuals with autism spectrum disorders (ASD) suggestive of a dysplastic process. In this study we identified areas of a...

    Authors: Manuel F Casanova, Ayman S El-Baz, Shweta S Kamat, Brynn A Dombroski, Fahmi Khalifa, Ahmed Elnakib, Ahmed Soliman, Anita Allison-McNutt and Andrew E Switala

    Citation: Acta Neuropathologica Communications 2013 1:67

    Content type: Research

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  22. Medulloblastoma is the most common malignant brain tumor in children. Genetic profiling has identified four principle tumor subgroups; each subgroup is characterized by different initiating mutations, genetic ...

    Authors: Kelsey L Whittier, Erin A Boese, Katherine N Gibson-Corley, Patricia A Kirby, Benjamin W Darbro, Qining Qian, Wendy J Ingram, Thomas Robertson, Marc Remke, Michael D Taylor and M Sue O’Dorisio

    Citation: Acta Neuropathologica Communications 2013 1:66

    Content type: Research

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  23. Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical and ...

    Authors: Jon B Toledo, Nigel J Cairns, Xiao Da, Kewei Chen, Deborah Carter, Adam Fleisher, Erin Householder, Napatkamon Ayutyanont, Auttawut Roontiva, Robert J Bauer, Paul Eisen, Leslie M Shaw, Christos Davatzikos, Michael W Weiner, Eric M Reiman, John C Morris…

    Citation: Acta Neuropathologica Communications 2013 1:65

    Content type: Research

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  24. There is an emerging association between ketamine abuse and the development of urological symptoms including dysuria, frequency and urgency, which have a neurological component. In addition, extreme cases are ...

    Authors: Simon C Baker, Jens Stahlschmidt, Jon Oxley, Jennifer Hinley, Ian Eardley, Fiona Marsh, David Gillatt, Simon Fulford and Jennifer Southgate

    Citation: Acta Neuropathologica Communications 2013 1:64

    Content type: Research

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  25. Congenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss (SNHL). The mechanisms of pathogenesis of CMV-related SNHL are still unclear. The aim is to study congenital CMV-rela...

    Authors: Liliana Gabrielli, Maria Paola Bonasoni, Donatella Santini, Giulia Piccirilli, Angela Chiereghin, Brunella Guerra, Maria Paola Landini, Maria Grazia Capretti, Marcello Lanari and Tiziana Lazzarotto

    Citation: Acta Neuropathologica Communications 2013 1:63

    Content type: Research

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  26. For the last 20 years, the “amyloid cascade hypothesis” has dominated research aimed at understanding, preventing, and curing Alzheimer’s disease (AD). During that time researchers have acquired an enormous am...

    Authors: Dimitrije Krstic and Irene Knuesel

    Citation: Acta Neuropathologica Communications 2013 1:62

    Content type: Review

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  27. Autism is a neurodevelopmental disorder of unknown etiopathogenesis associated with structural and functional abnormalities of neurons and increased formation of reactive oxygen species. Our previous study rev...

    Authors: Janusz Frackowiak, Bozena Mazur-Kolecka, N Carolyn Schanen, W Ted Brown and Jerzy Wegiel

    Citation: Acta Neuropathologica Communications 2013 1:61

    Content type: Research

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  28. The Arctic mutation (p.E693G/p.E22G)fs within the β-amyloid (Aβ) region of the β-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical Alzheimer’s disease. Here w...

    Authors: Hannu Kalimo, Maciej Lalowski, Nenad Bogdanovic, Ola Philipson, Thomas D Bird, David Nochlin, Gerard D Schellenberg, RoseMarie Brundin, Tommie Olofsson, Rabah Soliymani, Marc Baumann, Oliver Wirths, Thomas A Bayer, Lars NG Nilsson, Hans Basun, Lars Lannfelt…

    Citation: Acta Neuropathologica Communications 2013 1:60

    Content type: Research

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  29. Axon degeneration, a key pathological event in many neurodegenerative diseases and injury, can be induced by somatodendritic excitotoxin exposure. It is currently unclear, however, whether excitotoxin-induced ...

    Authors: Anna Elizabeth King, Katherine Adriana Southam, Justin Dittmann and James Clement Vickers

    Citation: Acta Neuropathologica Communications 2013 1:59

    Content type: Research

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  30. Cobblestone lissencephaly is a severe neuronal migration disorder associated with congenital muscular dystrophies (CMD) such as Walker-Warburg syndrome, muscle-eye-brain disease, and Fukuyama-type CMD. In thes...

    Authors: Huy Nguyen, Adam P Ostendorf, Jakob S Satz, Steve Westra, Susan E Ross-Barta, Kevin P Campbell and Steven A Moore

    Citation: Acta Neuropathologica Communications 2013 1:58

    Content type: Research

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  31. Persistent neuroinflammation and disruptions in brain energy metabolism is commonly seen in traumatic brain injury (TBI). Because of the lack of success of most TBI interventions and the documented benefits of...

    Authors: Teresita L Briones, Julie Woods and Magdalena Rogozinska

    Citation: Acta Neuropathologica Communications 2013 1:57

    Content type: Research

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  32. The amyloid hypothesis in Alzheimer disease (AD) considers amyloid β peptide (Aβ) deposition causative in triggering down-stream events like neurofibrillary tangles, cell loss, vascular damage and memory decli...

    Authors: Gregory Antonios, Nasrin Saiepour, Yvonne Bouter, Bernhard C Richard, Anders Paetau, Auli Verkkoniemi-Ahola, Lars Lannfelt, Martin Ingelsson, Gabor G Kovacs, Thierry Pillot, Oliver Wirths and Thomas A Bayer

    Citation: Acta Neuropathologica Communications 2013 1:56

    Content type: Research

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  33. The pathological features of the common neurodegenerative conditions, Alzheimer’s disease (AD), Parkinson’s disease and multiple sclerosis are all known to be associated with iron dysregulation in regions of t...

    Authors: Animesh Alexander Raha, Radhika Anand Vaishnav, Robert Paul Friedland, Adrian Bomford and Ruma Raha-Chowdhury

    Citation: Acta Neuropathologica Communications 2013 1:55

    Content type: Research

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  34. Intracytoplasmic inclusions composed of filamentous tau proteins are defining characteristics of neurodegenerative tauopathies, but it remains unclear why different tau isoforms accumulate in different disease...

    Authors: Ayaho Dan, Muneaki Takahashi, Masami Masuda-Suzukake, Fuyuki Kametani, Takashi Nonaka, Hiromi Kondo, Haruhiko Akiyama, Takao Arai, David MA Mann, Yuko Saito, Hiroyuki Hatsuta, Shigeo Murayama and Masato Hasegawa

    Citation: Acta Neuropathologica Communications 2013 1:54

    Content type: Research

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  35. In theory, cerebral biopsies could provide the diagnosis in a significant proportion of patients with neurodegenerative diseases, however, there are considerable ethical barriers. Previous series of cerebral b...

    Authors: Andrew King, Satomi Maekawa, Istvan Bodi, Claire Troakes, Olimpia Curran, Keyoumars Ashkan and Safa Al-Sarraj

    Citation: Acta Neuropathologica Communications 2013 1:53

    Content type: Research

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  36. Blast-induced neurotrauma (BINT) is the signature life threatening injury of current military casualties. Neuroinflammation is a key pathological occurrence of secondary injury contributing to brain damage aft...

    Authors: Yansong Li, Mikulas Chavko, Jessica L Slack, Bin Liu, Richard M McCarron, James D Ross and Jurandir J Dalle Lucca

    Citation: Acta Neuropathologica Communications 2013 1:52

    Content type: Research

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  37. Blast-related traumatic brain injury (TBI) has been a significant cause of injury in the military operations of Iraq and Afghanistan, affecting as many as 10-20% of returning veterans. However, how blast waves...

    Authors: Miguel A Gama Sosa, Rita De Gasperi, Alejandro J Paulino, Paul E Pricop, Michael C Shaughness, Eric Maudlin-Jeronimo, Aaron A Hall, William G M Janssen, Frank J Yuk, Nathan P Dorr, Dara L Dickstein, Richard M McCarron, Mikulas Chavko, Patrick R Hof, Stephen T Ahlers and Gregory A Elder

    Citation: Acta Neuropathologica Communications 2013 1:51

    Content type: Research

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  38. We have sought histological evidence, using TDP-43 and p62 immunohistochemistry, for the presence of expansions in C9ORF72 among 200 patients with pathologically confirmed AD.

    Authors: Yvonne S Davidson, Andrew C Robinson, Julie S Snowden and David MA Mann

    Citation: Acta Neuropathologica Communications 2013 1:50

    Content type: Research

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  39. TAR DNA-binding protein 43 (TDP-43) is a protein that is involved in the pathology of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In patients with these neurodegenerative ...

    Authors: Rui Liu, Guang Yang, Takashi Nonaka, Tetsuaki Arai, William Jia and Max S Cynader

    Citation: Acta Neuropathologica Communications 2013 1:49

    Content type: Research

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  40. Basement membranes in the walls of cerebral capillaries and arteries form a major lymphatic drainage pathway for fluid and solutes from the brain. Amyloid-β (Aβ) draining from the brain is deposited in such pe...

    Authors: Roxana Octavia Carare, Jessica Liesbeth Teeling, Cheryl A Hawkes, Ursula Püntener, Roy O Weller, James AR Nicoll and Victor Hugh Perry

    Citation: Acta Neuropathologica Communications 2013 1:48

    Content type: Research

    Published on:

  41. Focal cortical dysplasias (FCD) are local disturbances of neocortical architecture and a common cause of pharmaco-resistant focal epilepsy. Little is known about the pathomechanisms leading to architectural ab...

    Authors: Susanne Fauser, Ute Häussler, Catharina Donkels, Susanne Huber, Julia Nakagawa, Marco Prinz, Andreas Schulze-Bonhage, Josef Zentner and Carola A Haas

    Citation: Acta Neuropathologica Communications 2013 1:47

    Content type: Research

    Published on:

  42. Presenilin-1 (PS1) is the active component of the amyloid precursor protein cleaving γ-secretase complex. PS1 protein is a transmembrane protein containing multiple hydrophobic regions which presence in cerebr...

    Authors: María-Salud García-Ayllón, María-Letizia Campanari, Gunnar Brinkmalm, Alberto Rábano, Jordi Alom, Carlos A Saura, Niels Andreasen, Kaj Blennow and Javier Sáez-Valero

    Citation: Acta Neuropathologica Communications 2013 1:46

    Content type: Research

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  43. Monosomy 1p36 is the most common subtelomeric chromosomal deletion linked to mental retardation and seizures. Neuroimaging studies suggest that monosomy 1p36 is associated with brain malformations including po...

    Authors: Naoko Shiba, Ray AM Daza, Lisa G Shaffer, A James Barkovich, William B Dobyns and Robert F Hevner

    Citation: Acta Neuropathologica Communications 2013 1:45

    Content type: Case report

    Published on:

  44. PrPSc, the only known constituent of prions, the infectious agents causing prion diseases, can be detected by real-time quaking-induced conversion (RT-QuIC). However, there is no efficient method to quantify the ...

    Authors: Song Shi, Gerda Mitteregger-Kretzschmar, Armin Giese and Hans A Kretzschmar

    Citation: Acta Neuropathologica Communications 2013 1:44

    Content type: Methodology article

    Published on:

  45. Foamy macrophages, containing myelin degradation products, are abundantly found in active multiple sclerosis (MS) lesions. Recent studies have described an altered phenotype of macrophages after myelin interna...

    Authors: Jeroen FJ Bogie, Winde Jorissen, Jo Mailleux, Philip G Nijland, Noam Zelcer, Tim Vanmierlo, Jack Van Horssen, Piet Stinissen, Niels Hellings and Jerome JA Hendriks

    Citation: Acta Neuropathologica Communications 2013 1:43

    Content type: Research

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  46. A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caus...

    Authors: Axel Freischmidt, Kathrin Müller, Albert C Ludolph and Jochen H Weishaupt

    Citation: Acta Neuropathologica Communications 2013 1:42

    Content type: Research

    Published on:

  47. Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this ou...

    Authors: Orwa Aboud, Robert E Mrak, Frederick A Boop and W Sue T Griffin

    Citation: Acta Neuropathologica Communications 2013 1:41

    Content type: Research

    Published on:

  48. Central pontine myelinolysis (CPM) is a demyelinating disorder of the central basis pontis that is often associated with osmotic stress. The aquaporin water channels (AQPs) have been pathogenically implicated ...

    Authors: Bogdan F Gh Popescu, Reem F Bunyan, Yong Guo, Joseph E Parisi, Vanda A Lennon and Claudia F Lucchinetti

    Citation: Acta Neuropathologica Communications 2013 1:40

    Content type: Research

    Published on:

  49. Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth fac...

    Authors: Pan Pan and Rick T Dobrowsky

    Citation: Acta Neuropathologica Communications 2013 1:39

    Content type: Research

    Published on:

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