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  1. Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common radiological and histopathological features but the clinical ...

    Authors: Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta M. S. Lau, Paul G. Ekert and David S. Ziegler
    Citation: Acta Neuropathologica Communications 2021 9:147
  2. Synucleinopathies, including Parkinson’s disease (PD), Lewy body dementia (LBD), Alzheimer’s disease with amygdala restricted Lewy bodies (AD/ALB), and multiple system atrophy (MSA) comprise a spectrum of neur...

    Authors: Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop and Benoit I. Giasson
    Citation: Acta Neuropathologica Communications 2021 9:146
  3. Treatment with human pituitary-derived growth hormone (hGH) was responsible for a significant proportion of iatrogenic Creutzfeldt–Jakob disease (iCJD) cases. France and the UK experienced the largest case num...

    Authors: Jean-Yves Douet, Alvina Huor, Hervé Cassard, Séverine Lugan, Naïma Aron, Chloé Mesic, Didier Vilette, Tomás Barrio, Nathalie Streichenberger, Armand Perret-Liaudet, Marie-Bernadette Delisle, Patrice Péran, Jean-Philippe Deslys, Emmanuel Comoy, Jean-Luc Vilotte, Katayoun Goudarzi…
    Citation: Acta Neuropathologica Communications 2021 9:145
  4. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. The pattern of lower motor neuron loss along the spinal cord follow...

    Authors: Sarah Waters, Molly E. V. Swanson, Birger V. Dieriks, Yibin B. Zhang, Natasha L. Grimsey, Helen C. Murray, Clinton Turner, Henry J. Waldvogel, Richard L. M. Faull, Jiyan An, Robert Bowser, Maurice A. Curtis, Mike Dragunow and Emma Scotter
    Citation: Acta Neuropathologica Communications 2021 9:144
  5. Increasing evidence indicates that extracellular vesicles (EVs) play an important role in the pathogenesis of Alzheimer’s disease (AD). We previously reported that the blood–cerebrospinal fluid (CSF) interface...

    Authors: Charysse Vandendriessche, Sriram Balusu, Caroline Van Cauwenberghe, Marjana Brkic, Marie Pauwels, Nele Plehiers, Arnout Bruggeman, Pieter Dujardin, Griet Van Imschoot, Elien Van Wonterghem, An Hendrix, Femke Baeke, Riet De Rycke, Kris Gevaert and Roosmarijn E. Vandenbroucke
    Citation: Acta Neuropathologica Communications 2021 9:143
  6. The blood–brain barrier (BBB) plays important roles in brain tumor pathogenesis and treatment response, yet our understanding of its function and heterogeneity within or across brain tumor types remains poorly...

    Authors: Xin Wei, Michaël H. Meel, Marjolein Breur, Marianna Bugiani, Esther Hulleman and Timothy N. Phoenix
    Citation: Acta Neuropathologica Communications 2021 9:142
  7. Traditionally, analysis of neuropathological markers in neurodegenerative diseases has relied on visual assessments of stained sections. Resulting semiquantitative scores often vary between individual raters a...

    Authors: Valentina Perosa, Ashley A. Scherlek, Mariel G. Kozberg, Lindsey Smith, Thomas Westerling-Bui, Corinne A. Auger, Serge Vasylechko, Steven M. Greenberg and Susanne J. van Veluw
    Citation: Acta Neuropathologica Communications 2021 9:141
  8. The microglial reaction is a hallmark of neurodegenerative conditions, and elements thereof may exert differential effects on disease progression, either worsening or ameliorating severity. In amyotrophic late...

    Authors: Mandana Hunter, Krista J. Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Richard M. Ransohoff, John Q. Trojanowski and Virginia M.-Y. Lee
    Citation: Acta Neuropathologica Communications 2021 9:140
  9. The etiology of sporadic Parkinson’s disease (PD) remains uncertain, but genetic, epidemiological, and physiological overlap between PD and inflammatory bowel disease suggests that gut inflammation could promo...

    Authors: Madelyn C. Houser, W. Michael Caudle, Jianjun Chang, George T. Kannarkat, Yuan Yang, Sean D. Kelly, Danielle Oliver, Valerie Joers, Kathleen M. Shannon, Ali Keshavarzian and Malú Gámez Tansey
    Citation: Acta Neuropathologica Communications 2021 9:139
  10. Traumatic brain injury (TBI) causes acute and subacute tissue damage, but is also associated with chronic inflammation and progressive loss of brain tissue months and years after the initial event. The trigger...

    Authors: Antonia Clarissa Wehn, Igor Khalin, Marco Duering, Farida Hellal, Carsten Culmsee, Peter Vandenabeele, Nikolaus Plesnila and Nicole Angela Terpolilli
    Citation: Acta Neuropathologica Communications 2021 9:138
  11. Down syndrome (DS) is the leading genetic cause of intellectual disability and causes early-onset dementia and cerebellar hypoplasia. The prevalence of attention deficit hyperactivity disorder is elevated in c...

    Authors: Feng J. Gao, Donna Klinedinst, Fabian-Xosé Fernandez, Bei Cheng, Alena Savonenko, Benjamin Devenney, Yicong Li, Dan Wu, Martin G. Pomper and Roger H. Reeves
    Citation: Acta Neuropathologica Communications 2021 9:137
  12. Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the bloo...

    Authors: Mariángeles Kovacs, Catalina Alamón, Cecilia Maciel, Valentina Varela, Sofía Ibarburu, Lucas Tarragó, Peter H. King, Ying Si, Yuri Kwon, Olivier Hermine, Luis Barbeito and Emiliano Trias
    Citation: Acta Neuropathologica Communications 2021 9:136
  13. The cIMPACT-NOW Update 7 has replaced the WHO nosology of “ependymoma, RELA fusion positive” by “Supratentorial-ependymoma, C11orf95-fusion positive”. This modification reinforces the idea that supratentorial-epe...

    Authors: Arnault Tauziède-Espariat, Aurore Siegfried, Yvan Nicaise, Thomas Kergrohen, Philipp Sievers, Alexandre Vasiljevic, Alexandre Roux, Edouard Dezamis, Chiara Benevello, Marie-Christine Machet, Sophie Michalak, Chloe Puiseux, Francisco Llamas-Gutierrez, Pierre Leblond, Franck Bourdeaut, Jacques Grill…
    Citation: Acta Neuropathologica Communications 2021 9:135
  14. Primary age-related tauopathy (PART) is a form of Alzheimer-type neurofibrillary degeneration occurring in the absence of amyloid-beta (Aβ) plaques. While PART shares some features with Alzheimer disease (AD),...

    Authors: Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson, Gabriel A. Marx, Clare H. Bryce, Dushyant Purohit, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, Etty P. Cortes, Marla Gearing, Vahram Haroutunian, Corey T. McMillan, Edward B. Lee, Dennis W. Dickson…
    Citation: Acta Neuropathologica Communications 2021 9:134
  15. The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Im...

    Authors: Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T. Daniel, Andreas F. Hottinger and Monika E. Hegi
    Citation: Acta Neuropathologica Communications 2021 9:133
  16. We identified an autosomal dominant progranulin mutation carrier without symptoms of dementia in her lifetime (Reduced Penetrance Mutation Carrier, RedPenMC). This resistance to develop expected pathology present...

    Authors: Karthick Natarajan, Jesper Eisfeldt, Maria Hammond, José Miguel Laffita-Mesa, Kalicharan Patra, Behzad Khoshnood, Linn Öijerstedt and Caroline Graff
    Citation: Acta Neuropathologica Communications 2021 9:132
  17. Although the right temporal variant frontotemporal dementia (rtvFTD) is characterised by distinct clinical and radiological features, its underlying histopathology remains elusive. Being considered a right-sid...

    Authors: Hulya Ulugut, Anke A. Dijkstra, Marta Scarioni, Frederik Barkhof, Philip Scheltens, Annemieke J. M. Rozemuller and Yolande A. L. Pijnenburg
    Citation: Acta Neuropathologica Communications 2021 9:131
  18. Cerebral pericytes are an integral component of the neurovascular unit, which governs the blood–brain barrier. There is paucity of knowledge on cortical pericytes across different dementias. We quantified cort...

    Authors: Ren Ding, Yoshiki Hase, Matthew Burke, Vincent Foster, William Stevenson, Tuomo Polvikoski and Raj N. Kalaria
    Citation: Acta Neuropathologica Communications 2021 9:130
  19. The pathogenic mechanisms underlying the development of Alzheimer’s disease (AD) remain elusive and to date there are no effective prevention or treatment for AD. Farnesyltransferase (FT) catalyzes a key postt...

    Authors: Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergö and Ling Li
    Citation: Acta Neuropathologica Communications 2021 9:129
  20. The medial temporal lobe (MTL) is a nidus for neurodegenerative pathologies and therefore an important region in which to study polypathology. We investigated associations between neurodegenerative pathologies...

    Authors: L. E. M. Wisse, S. Ravikumar, R. Ittyerah, S. Lim, J. Lane, M. L. Bedard, L. Xie, S. R. Das, T. Schuck, M. Grossman, E. B. Lee, M. D. Tisdall, K. Prabhakaran, J. A. Detre, G. Mizsei, J. Q. Trojanowski…
    Citation: Acta Neuropathologica Communications 2021 9:128
  21. Nuclear pore complex injury has recently emerged as an early and significant contributor to familial and sporadic ALS disease pathogenesis. However, the molecular events leading to this pathological phenomenon...

    Authors: Alyssa N. Coyne and Jeffrey D. Rothstein
    Citation: Acta Neuropathologica Communications 2021 9:127
  22. Activation of the complement system propagates neuroinflammation and brain damage early and chronically after traumatic brain injury (TBI). The complement system is complex and comprises more than 50 component...

    Authors: Amer Toutonji, Mamatha Mandava, Silvia Guglietta and Stephen Tomlinson
    Citation: Acta Neuropathologica Communications 2021 9:126
  23. Peripheral nerve injury is a serious health problem and repairing long nerve deficits remains a clinical challenge nowadays. Nerve guidance conduit (NGC) serves as the most promising alternative therapy strate...

    Authors: Feixiang Chen, Weihuang Liu, Qiang Zhang, Ping Wu, Ao Xiao, Yanan Zhao, Ying Zhou, Qiaona Wang, Yun Chen and Zan Tong
    Citation: Acta Neuropathologica Communications 2021 9:125
  24. The cellular and molecular mechanisms that drive neurodegeneration remain poorly defined. Recent clinical trial failures, difficult diagnosis, uncertain etiology, and lack of curative therapies prompted us to ...

    Authors: Pooja Jadiya, Joanne F. Garbincius and John W. Elrod
    Citation: Acta Neuropathologica Communications 2021 9:124
  25. Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and deficient levels cause spinal cord motoneurons (MNs) degeneration a...

    Authors: Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler and Ana Garcera
    Citation: Acta Neuropathologica Communications 2021 9:122
  26. Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affec...

    Authors: Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius and Hannelore Ehrenreich
    Citation: Acta Neuropathologica Communications 2021 9:121
  27. Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) neoplasm in adults, and has an almost universally poor prognosis. Recently, an emphasis on genetic and epigenetic profiling ...

    Authors: James F. Lyon, Varshini Vasudevaraja, Kanish Mirchia, Jamie M. Walker, Robert J. Corona, Lawrence S. Chin, Ivy Tran, Matija Snuderl, Timothy E. Richardson and Mariano S. Viapiano
    Citation: Acta Neuropathologica Communications 2021 9:120
  28. Primary spinal cord astrocytomas are rare, hence few data exist about the prognostic significance of molecular markers. Here we analyze a panel of molecular alterations in association with the clinical course....

    Authors: Annamaria Biczok, Felix L. Strübing, Julia M. Eder, Rupert Egensperger, Oliver Schnell, Stefan Zausinger, Julia E. Neumann, Jochen Herms, Joerg-Christian Tonn and Mario M. Dorostkar
    Citation: Acta Neuropathologica Communications 2021 9:119
  29. Traumatic brain injury (TBI) constitutes one of the strongest environmental risk factors for several progressive neurodegenerative disorders of cognitive impairment and dementia that are characterized by the p...

    Authors: Aydan Kahriman, James Bouley, Thomas W. Smith, Daryl A. Bosco, Amanda L. Woerman and Nils Henninger
    Citation: Acta Neuropathologica Communications 2021 9:118
  30. Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneles...

    Authors: Pamela J. McMillan, Timothy J. Strovas, Misa Baum, Brooke K. Mitchell, Randall J. Eck, Nzinga Hendricks, Jeanna M. Wheeler, Caitlin S. Latimer, C. Dirk Keene and Brian C. Kraemer
    Citation: Acta Neuropathologica Communications 2021 9:117
  31. Sustained brain chronic inflammation in Alzheimer’s disease (AD) includes glial cell activation, an increase in cytokines and chemokines, and lipid mediators (LMs), concomitant with decreased pro-homeostatic m...

    Authors: Ceren Emre, Khanh V. Do, Bokkyoo Jun, Erik Hjorth, Silvia Gómez Alcalde, Marie-Audrey I. Kautzmann, William C. Gordon, Per Nilsson, Nicolas G. Bazan and Marianne Schultzberg
    Citation: Acta Neuropathologica Communications 2021 9:116
  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera and Akiyoshi Kakita
    Citation: Acta Neuropathologica Communications 2021 9:115

    The original article was published in Acta Neuropathologica Communications 2021 9:106

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller and Noah E. Berlow
    Citation: Acta Neuropathologica Communications 2021 9:114

    The original article was published in Acta Neuropathologica Communications 2021 9:88

  34. Tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including Alzheimer’s disease (AD). Earlier reports showed that adenosine metabolism is abnormal in...

    Authors: Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum and Yijuang Chern
    Citation: Acta Neuropathologica Communications 2021 9:112
  35. The deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms that caus...

    Authors: Isil Keskin, Elaheh Ekhtiari Bidhendi, Matthew Marklund, Peter M. Andersen, Thomas Brännström, Stefan L. Marklund and Ulrika Nordström
    Citation: Acta Neuropathologica Communications 2021 9:111
  36. The synthesis of new proteins is a fundamental aspect of cellular life and is required for many neurological processes, including the formation, updating and extinction of long-term memories. Protein synthesis...

    Authors: Harrison Tudor Evans, Deonne Taylor, Andrew Kneynsberg, Liviu-Gabriel Bodea and Jürgen Götz
    Citation: Acta Neuropathologica Communications 2021 9:110
  37. Hypokalemic periodic paralysis is an autosomal dominant, rare disorder caused by variants in the genes for voltage-gated calcium channel CaV1.1 (CACNA1S) and NaV1.4 (SCN4A). Patients with hypokalemic periodic par...

    Authors: Thomas O. Krag, Sonja Holm-Yildiz, Nanna Witting and John Vissing
    Citation: Acta Neuropathologica Communications 2021 9:109
  38. Alzheimer's disease (AD) is characterized by a sequential progression of amyloid plaques (A), neurofibrillary tangles (T) and neurodegeneration (N), constituting ATN pathology. While microglia are considered k...

    Authors: Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi and Ilse Dewachter
    Citation: Acta Neuropathologica Communications 2021 9:108
  39. Pathophysiological changes in dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease (PD). Intracellular pathological inclusions of the protein α-synuclein within dopam...

    Authors: Min Lin, Phillip M. Mackie, Fatima Shaerzadeh, Joyonna Gamble-George, Douglas R. Miller, Chris J. Martyniuk and Habibeh Khoshbouei
    Citation: Acta Neuropathologica Communications 2021 9:107
  40. Authors: Makoto Sainouchi, Yuya Hatano, Mari Tada, Tomohiko Ishihara, Shoichiro Ando, Taisuke Kato, Jun Tokunaga, Gaku Ito, Hiroaki Miyahara, Yasuko Toyoshima, Akio Yokoseki, Tetsutaro Ozawa, Kohei Akazawa, Osamu Onodera and Akiyoshi Kakita
    Citation: Acta Neuropathologica Communications 2021 9:106

    The Correction to this article has been published in Acta Neuropathologica Communications 2021 9:115

  41. Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several fi...

    Authors: Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vægter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen and Asad Jan
    Citation: Acta Neuropathologica Communications 2021 9:105
  42. The prevalence of congenital hydrocephalus has been estimated at 1.1 per 1000 infants when including cases diagnosed before 1 year of age after exclusion of neural tube defects. Classification criteria are bas...

    Authors: Florent Marguet, Myriam Vezain, Pascale Marcorelles, Séverine Audebert-Bellanger, Kévin Cassinari, Nathalie Drouot, Pascal Chambon, Bruno J. Gonzalez, Arie Horowitz, Annie Laquerriere and Pascale Saugier-Veber
    Citation: Acta Neuropathologica Communications 2021 9:104
  43. The blood–brain barrier is a dynamic endothelial cell barrier in the brain microvasculature that separates the blood from the brain parenchyma. Specialized brain endothelial cells, astrocytes, neurons, microgl...

    Authors: Parand Zarekiani, Marjolein Breur, Nicole I. Wolf, Helga E. de Vries, Marjo S. van der Knaap and Marianna Bugiani
    Citation: Acta Neuropathologica Communications 2021 9:103
  44. Alzheimer’s disease (AD) is a progressive neurodegenerative disease with high prevalence rate among the elderly population. A large number of clinical studies have suggested repetitive transcranial magnetic st...

    Authors: Yangyang Lin, Jian Jin, Rongke Lv, Yuan Luo, Weiping Dai, Wenchang Li, Yamei Tang, Yuling Wang, Xiaojing Ye and Wei-Jye Lin
    Citation: Acta Neuropathologica Communications 2021 9:102
  45. Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors...

    Authors: Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown and Christopher G. Hubert
    Citation: Acta Neuropathologica Communications 2021 9:101
  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tatsuya Ozawa, Syuzo Kaneko, Frank Szulzewsky, Zhiwei Qiao, Mutsumi Takadera, Yoshitaka Narita, Tadashi Kondo, Eric C. Holland, Ryuji Hamamoto and Koichi Ichimura
    Citation: Acta Neuropathologica Communications 2021 9:100

    The original article was published in Acta Neuropathologica Communications 2021 9:36

  47. Tau protein forms self-replicating assemblies (seeds) that may underlie progression of pathology in Alzheimer’s disease (AD) and related tauopathies. Seeding in recombinant protein preparations and brain homog...

    Authors: Brian D. Hitt, Jaime Vaquer-Alicea, Victor A. Manon, Joshua D. Beaver, Omar M. Kashmer, Jan N. Garcia and Marc I. Diamond
    Citation: Acta Neuropathologica Communications 2021 9:99
  48. Short tandem repeat (STR) expansion disorders are an important cause of human neurological disease. They have an established role in more than 40 different phenotypes including the myotonic dystrophies, Fragil...

    Authors: Sanjog R. Chintalaphani, Sandy S. Pineda, Ira W. Deveson and Kishore R. Kumar
    Citation: Acta Neuropathologica Communications 2021 9:98

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