Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils

Fig. 3

Glial responses and cytokine expression in the retina of PFF-injected mice. A Representative images of Müller glia identified based on GFAP immunoreactivity. BD Quantification of GFAP intensity across the GCL and IPL layers of the retina at 1 month (B), 2 months (C), and 5 months (D) after injection of PFFs. E Representative images of Iba-1–immunostained microglia. FH Quantification of Iba-1 intensity in the IPL layers at 1 month (F), 2 months (G), and 5 months (H). I mRNA expression of proinflammatory cytokines Il-1β, TNF- α, IFNγ and IL-10 in the retina of 2 months after injection, quantified by RT-qPCR. Data values are expressed as means ± s.e.m. (Data from (AD): PBS, n = 5 mice; PFF, n = 5 mice; I: PBS, n = 4 mice; PFF, n = 4 mice *p < 0.05, **p < 0.01, ***p < 0.001; Student’s t-test)

Back to article page