Myelin modifications | References |
---|---|
Demyelination (as evidenced, for example, by decreased myelin water fraction) | |
Rupture of the myelin envelope | |
Myelin reshuffle | |
Defect in myelin biosynthesis (loss of ceramide synthase 2 activity) | [32] |
Down-regulation of myelination network | [3] |
Morphological abnormalities of myelin sheaths, in the form of edema and thinning of the envelope surrounding myelinated axons | |
Myelin degeneration -> driving cognitive and motor impairment | |
Changes of myelin organization (q-Space myelin map imaging) | [148] |
Myelin instability | |
Myelin damage in cortical gray matter (Western blot quantification of MBP and dMBP) | [227] |
Decrease of myelin density (multi-echo T2 relaxation time technique) | [99] |