Skip to main content

Table 1 Examples of different outcomes of myelin damages

From: Myelin in Alzheimer’s disease: culprit or bystander?

Myelin modifications

References

Demyelination (as evidenced, for example, by decreased myelin water fraction)

[18, 48, 83, 94, 137, 177]

Rupture of the myelin envelope

[38, 150, 202]

Myelin reshuffle

[16, 47, 165, 179]

Defect in myelin biosynthesis (loss of ceramide synthase 2 activity)

[32]

Down-regulation of myelination network

[3]

Morphological abnormalities of myelin sheaths, in the form of edema and thinning of the envelope surrounding myelinated axons

[49, 137, 229]

Myelin degeneration -> driving cognitive and motor impairment

[27, 153]

Changes of myelin organization (q-Space myelin map imaging)

[148]

Myelin instability

[35, 203]

Myelin damage in cortical gray matter (Western blot quantification of MBP and dMBP)

[227]

Decrease of myelin density (multi-echo T2 relaxation time technique)

[99]