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Fig. 18 | Acta Neuropathologica Communications

Fig. 18

From: Late chronic local inflammation, synaptic alterations, vascular remodeling and arteriovenous malformations in the brains of male rats exposed to repetitive low-level blast overpressures

Fig. 18

Blast-induced tear, tissue repositioning and vascular remodeling. a-d, Section stained with antibodies against β-III tubulin (neuronal, green), GFAP (astrocytic, red) and collagen type IV (vascular ECM, white). a, Merged image; b, β-III tubulin and GFAP immunostaining; c, GFAP immunostaining; and d; collagen type IV and GFAP immunostaining. Nuclei were stained with DAPI (blue). Note the tear (indicated by the arrows in a-e and h) in the lateral septum that follows a large penetrating vessel, and reactive astrocytosis associated with resulting tissue repositioning (insert in c) and collagen type IV immunostaining of the microvasculature in the area associated with the lesion in absence of protease pretreatment (vascular remodeling). e–h, Remnants of perivascular inflammation in the region of the tear illustrated above. β-III tubulin (neuronal, green), GFAP (astrocytic, red) and Iba1 (microglia, white) immunostaining. e, Merged image; f, β-III tubulin and GFAP immunostaining; g, GFAP immunostaining; and h, Iba1 immunostaining. Note in the adjacent neuropil the presence of ramified type 1 Iba1-expressing cells and the lack of ameboid microglia, while on the large vasculature only remnants of Iba1-immunoreactive material are present. Scale, 500 µm in a-d and 100 µm in e–h

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