Fig. 5

Representative EM images of neuronal cell bodies from an AD case (A) and control case (C). Enlarged images of the boxed regions show mitochondria in neurons and nearby synapses (B, D). Presynaptic terminals are colored light blue, the dendritic spines are colored light yellow, and some mitochondria are noted with red arrows. There are fewer mitochondria per neuronal area in the AD cases (E, p < 0.05). Morphological analysis finds that the mitochondria aspect ratio is lower in AD (F, p < 0.01) and the mean mitochondria is larger in AD (G, p < 0.05). On average, more mitochondria display a damaged morphology in the AD cases, compared to the control cases (H, p < 0.05). Data are Means ± S.E.M. of 16 AD neurons and 15 control neurons from six AD and six control cases. Student t test (E–H). *p < 0.05, **p < 0.01