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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain

Fig. 3

Correlation of mitochondrial changes with synaptic vesicle numbers and morphology in all cases. There is a strong correlation of the mean # of mitochondria per presynapse against mean vesicle density per case using regression analysis (A, p < 0.01). The prevalence of damaged mitochondria is negatively correlated with vesicle density (B, p < 0.01). The presence of enlarged vesicles and DCVs is correlated with damaged mitochondria (C, p < 0.001). A greater number of enlarged vesicles and DCVs is negatively correlated with vesicle density (D, p < 0.01). The AD cases (blue circles) often cluster as a group compared to the control cases (red circles). **p < 0.01, ***p < 0.001

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