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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

Fig. 6

Lysosomal and phagocytic markers are increased in both FTD-GRN and FTD-C9orf72. (A, C, E) Representative western blots and (B, D, F) densitometric quantification for LAMP1, LAMP2, TREM2 and CD68 in (A, B) frontal grey matter, (C, D) frontal white matter and (E, F) parietal white matter of control (n = 11), FTD-C9orf72 (n = 11), and FTD-GRN (n = 6) cases. Protein levels were normalised to β-actin or GAPDH as a loading control, and expressed relative to the mean of the control group. Asterisks indicate significant difference in Tukey’s post-test after one-way ANOVA: *p < 0.05; **p < 0.01; ***p < 0.001

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Acta Neuropathologica Communications

ISSN: 2051-5960

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