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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Disrupted myelin lipid metabolism differentiates frontotemporal dementia caused by GRN and C9orf72 gene mutations

Fig. 4

Pronounced myelin loss in FTD-GRN. (A, C) Representative western blots and (B, D) densitometric quantification of PLP, CNP, MBP, βIII-tubulin (βIII-T) and neurofilament light chain (NF-L) in (A, B) superior frontal white matter, and (C, D) superior parietal white matter from control (n = 11), FTD-C9orf72 (n = 11), and FTD-GRN (n = 6) cases. Protein levels were normalised to β-actin or GAPDH as a loading control, and are expressed relative to the mean of the control group. (E) Representative images and (F) myelination scores from LFB staining of superior frontal gyrus white matter from control (n = 5), FTD-C9orf72 (n = 4), and FTD-GRN (n = 3) cases from which tissue fixed for < 2 weeks was available. (G) Representative ASPA (red) and MBP (green) staining in superior frontal gyrus white matter, and (H) ASPA-positive cell density. Groups were compared by one-way ANOVA with Tukey’s post-test (B,D,H) or Kruskall-Wallis test with Dunn’s post-test (F): *p < 0.05; **p < 0.01; ***p < 0.001

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