Fig. 1

TDP-43 cytoplasmic inclusions and dystrophic neurites are similar between FTD-GRN and FTD-C9orf72 cases. (A-D) Representative images of phosphorylated TDP-43 staining in grey matter, showing (A) a control case with no TDP-43 inclusions, (B) mild (score = 1), (C) moderate (score = 2), and (D) severe (score = 3) TDP-43 pathology. (E) Abundant TDP-43-positive dystrophic neurites (score = 3) in frontal white matter of an FTD case. Scale bar, 20 µM. (F-I) Severity of (F) neuronal cytoplasmic TDP-43 inclusions in frontal grey matter, (G) glial cytoplasmic inclusions in frontal white matter, (H) TDP-43-positive dystrophic neurites in frontal grey matter, and (I) dystrophic neurites in frontal white matter of FTD-C9orf72 (n = 11) and FTD-GRN (n = 6) cases