Cerebellar presence of immune cells in patients with neuro-coeliac disease

Table 4 The estimated mean cell count per area per patient comparing cell count in different cerebellar layers between groups

IHC staining	Layer	NeuroCD	CI lower	CI upper	Spino-cerebellar Ataxia	CI lower	CI upper	Non-neurological control	CI lower	CI upper	Bonferroni P NeuroCD_vs_SCA	Bonferroni P NeuroCD_vs_NNC
CD3	Molecular Layer	2.75	1.61	4.69	0.14	0.07	0.27	0.57	0.27	1.18	0.001	0.015
	Purkinje Cell Layer	4.57	2.77	7.54	0.24	0.07	0.81	0.87	0.36	2.09	0.001	0.008
	Granular Layer	3.23	1.97	5.31	0.36	0.16	0.83	0.77	0.25	2.32	0.002	0.023
	White Matter	3.42	1.96	5.97	0.54	0.21	1.42	0.52	0.22	1.21	0.013	0.011
	Perivascular	2.00	1.19	3.35	0.72	0.41	1.27	0.43	0.29	0.65	0.072	0.010
	TOTAL COUNT	15.97	9.76	26.13	2.00	0.96	4.17	3.15	1.53	6.48	0.002	0.006
CD8	Molecular Layer	1.35	0.70	2.61	0.20	0.14	0.30	0.08	0.04	0.16	0.035	0.016
	Purkinje Cell Layer	2.30	1.18	4.47	0.10	0.06	0.17	0.08	0.03	0.23	0.015	0.014
	Granular Layer	2.23	1.07	4.65	0.06	0.03	0.12	0.18	0.09	0.38	0.028	0.043
	White Matter	4.02	1.99	8.11	0.36	0.16	0.81	0.08	0.04	0.20	0.035	0.019
	TOTAL COUNT *	12.35	6.29	24.26	1.16	0.79	1.70	0.92	0.39	2.15	0.026	0.022
Calbindin		1.13	0.61	2.11	2.50	1.51	4.15	6.04	5.14	7.10	0.194	0.000

The total count is a summation of all layers. A generalised estimating equation was performed with a post-hoc Bonferroni to correct for the different measurements within patient groups. * Including perivascular cells, CI Confidence interval was 95%, upper and lower limit are indicated per measurement. p values < 0.05 were considered statistically significant. IHC Immunohistochemistry, NeuroCD Neurocoeliac disease, SCA Spinocerebellar ataxia, NNC Non-neurological controls

ISSN: 2051-5960