Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Table 4 Effects of MAPT haplotype and disease status on levels of tau isoforms and α-syn in the soluble protein fraction in human samples of fusiform gyrus and cerebellum

Protein fraction	Brain region	Two-way ANOVA	Main effect of haplotype	Main effect of disease	Haplotype × disease	Direction of significant effect
Protein fraction	Brain region	P value	P value	P value	P value	Direction of significant effect
α-syn	ctx-fg	0.830	0.595	0.511	0.899	–
	ctx-cbl	0.926	0.563	0.946	0.790	–
Total tau	ctx-fg	0.737	0.279	0.877	0.908	–
	ctx-cbl	0.285	0.415	0.875	0.077	–
0N3R tau	ctx-fg	0.312	0.101	0.406	0.734	–
	ctx-cbl	0.207	0.207	0.150	0.205	–
0N4R tau	ctx-fg	0.341	0.103	0.479	0.724	–
	ctx-cbl	0.301	0.176	0.332	0.251	–
1N3R tau	ctx-fg	0.308	0.093	0.455	0.721	–
	ctx-cbl	0.412	0.223	0.519	0.263	–
1N4R tau	ctx-fg	0.446	0.145	0.552	0.700	–
	ctx-cbl	0.480	0.898	0.919	0.132	–
2N3R tau	ctx-fg	0.538	0.653	0.184	0.551	–
	ctx-cbl	0.581	0.251	0.574	0.610	–
2N4R tau	ctx-fg	0.709	0.316	0.607	0.749	–
	ctx-cbl	0.072	0.569	0.482	0.052	–

Main effect of haplotype was analyzed by comparison of H1/H1 (Controls + PD) versus H2/H2 (Controls + PD). Main effect of disease was analyzed by comparison of PD (H1/H1 + H2/H2) versus Controls (H1/H1 + H2/H2). The interaction haplotype × disease examined the relationship between the independent variables (haplotype + disease) on the dependent variable of protein levels. P values were calculated using two-way ANOVA followed by Tukey’s multiple comparisons test
ctx-fg, cortex of fusiform gyrus; ctx-cbl, cerebellum.

ISSN: 2051-5960