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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Cell-specific vulnerability to metabolic failure: the crucial role of parvalbumin expressing neurons in creatine transporter deficiency

Fig. 1

Differentially expressed genes in the cerebral cortex of CrT−/y mice. a Volcano plot of the DEGs in the bulk RNA-seq data sets from CrT+/y (n = 3) and CrT−/y (n = 4) animals. Red points mark the significantly up- or downregulated genes in the CrT−/y cerebral cortex (p < 0.1). b,d Fold enrichment of top-level overrepresented GO terms for biological process (BP) highlighting metabolic pathways in the set of upregulated genes (b) and synaptic pathways in the set of downregulated genes (d). c,e Fold enrichment of top-level overrepresented GO terms for cellular component (CC) highlighting ribosomes and mitochondria in the set of upregulated genes (c), and ER and synapses in the set of downregulated genes (e). Calculated by ShinyGO 0.76.3, FDR < 0.05

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